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Ryan Arnold

Ryan Arnold, MD

Associate Professor

Department: Emergency Medicine

Specialties: Emergency Medicine


  • MD - Loma Linda University School of Medicine
  • MS in Medical Science - Boston University School of Medicine

Memberships / Professional Affiliations

  • Alpha Omega Alpha Honor Medical Society
  • American College of Emergency Physicians
  • American Academy of Emergency Medicine
  • Society for Academic Emergency Medicine

Ryan Arnold, MD, is a board-certified emergency medicine physician. He has a clinical interest in critical care medicine, cardiopulmonary resuscitation and sepsis.

Clinical Services

Critical care, Emergency medical procedures


  • Shock Research - Cooper University Hospital


  • Emergency Medicine - Cooper University Hospital

Ryan Arnold, MD, is an associate professor in the Department of Emergency Medicine at Drexel University College of Medicine.


Dr. Arnold completed a fellowship in shock research at Cooper University Hospital, focused on the design and execution of emergency medicine and critical care–based clinical trials. For over 10 years, Dr. Arnold has focused his primary investigative efforts on several key aspects of the care of the sepsis patient, from novel diagnostic biomarkers and risk-stratification of sepsis, to clinical trials investigating the effectiveness of resuscitation protocols and novel therapeutic agents. He has participated as both principal and co-investigator in multiple prospective clinical trials with both NIH-funded and industry-supported investigations. Throughout his years as a clinical researcher, Dr. Arnold has served as a peer reviewer for several scientific journals, and is experienced in leading successful guideline development, health care consensus, and quality care initiatives.

Current areas of research focus include:

  • Defining the phenotypic endotypes of sepsis through a machine-learning approach coupled with predictive analytics applied to Big Data, focused on defining the phenotypic endotypes within sepsis. These endotypes, based on clinically available electronic health record data, divide the heterogeneous sepsis population into unique measureable subgroups based on proximal (shock development or recovery) and ultimate outcomes (survivability). In a model based on oncology subgrouping, defining sepsis endotypes will assist in personalizing diagnostic interpretation and therapeutic interventions. (Supported by a National Science Foundation Smart and Connected Health Grant).
  • Development of a sepsis clinical decision support (CDS) tool, targeting an improvement in sepsis awareness through development of an enhanced visual display incorporating end-user design to improve the impact of sepsis-specific CDS. (Supported by grant from NIH-National Library of Medicine.)
  • Improving medical decision-making for sepsis during clinical uncertainty, differentiating between preventable diagnostic errors secondary to irrational yet traditional heuristics versus unavoidable errors due to clinical uncertainty. 

In the Media


"The association of near infrared spectroscopy-derived StO2 measurements and biomarkers of endothelial activation in sepsis"
Skibsted S, Arnold R, Sherwin R, Singh S, Lundy D, Nelson T, Puskarich MA, Trzeciak S, Jones AE, Shapiro NI
Intern Emerg Med. Sep 2013

"Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department"
Arnold RC, Sherwin R, Shapiro NI, O'Connor JL, Glaspey L, Singh S, Medado P, Trzeciak S, Jones AE
Acad Emerg Med. May 16, 2013

"Biomarkers of Endothelial Cell Activation in Early Sepsis"
Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI
Shock. May 2013

"Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability"
Arnold RC, Dellinger RP, Parrillo JE, Chansky ME, Lotano VE, McCoy JV, Jones AE, Shapiro NI, Hollenberg SM, Trzeciak S
J Crit Care. Oct 2012

"Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside"
Seely AJ, Kauffman SA, Bates JH, Macklem PT, Suki B, Marshall JC, Batchinsky AI, Perez-Velazquez JL, Seiver A, McGregor C, Maksym G, Kamath MV, Similowski T, Buchman TG, Letellier C, Filoche M, Frasch MG, Straus C, Glass L, Godin PJ, Morris JA, Sow D, Nenadovic V, Arnold RC, Norris P, Moorman JR
J Crit Care. Jun 2011

"Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol"
Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE; Emergency Medicine Shock Research Network (EMSHOCKNET);
Crit Care Med. Sep 2011

"A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation"
Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP
Crit Care Med. Apr 2010

"Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial"
Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA
JAMA. Feb 24, 2010

"Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis"
Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI
Ann Emerg Med. Jan 1, 2010

"Point-of-care assessment of microvascular blood flow in critically ill patients"
Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM
Intensive Care Med. October 1, 2009

"Continuous cardiac index monitoring: A prospective observational study of agreement between a pulmonary artery catheter and a calibrated minimally invasive technique"
McCoy JV, Hollenberg SM, Dellinger RP, Arnold RC, Ruoss L, Lotano V, Peters P, Parrillo JE, Trzeciak S
Resuscitation. Aug 1, 2009

"Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis"
Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators; Shock. Jul 1, 2009

"Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis"
Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM
Intensive Care Med. Dec 2008

"Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials"
Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM; Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators.;
Acad Emerg Med. May 2008

"Serum lactate as a predictor of mortality in patients with infection"
Trzeciak S, Dellinger RP, Chansky ME, Arnold RC, Schorr C, Milcarek B, Hollenberg SM, Parrillo JE
Intensive Care Med. Jun 2007

"Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival"
Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, Arnold RC, Colilla S, Zanotti S, Hollenberg SM
Ann Emerg Med. Jan 2007

Contact Information

Academic Office

Drexel Emergency Medicine
245 N. 15th Street
MS 1011
Philadelphia, PA 19102
Phone: 215.762.2368
Fax: 215.762.1307