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Joanne Morrisey

Joanne Morrisey

Research Instructor


Department: Microbiology & Immunology

Education

  • BA in Chemistry - Douglas College, Rutgers University

Joanne Morrisey is a research instructor in the Department of Microbiology & Immunology at Drexel University College of Medicine.

Research

Joanne Morrisey has served as a research instructor with the College of Medicine and its predecessor institutions since 1984. Prior to that she served as a research technician at Rockefeller University in New York, New York, and the supervisor of clinical rheumatology at Upjohn Corporation in Philadelphia.

Publications

Recent Full-Length Papers

"Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity"
Hangjun Ke, Joanne M. Morrisey, Shiwei Qu, Oraphin Chantarasriwong, Michael W. Mather, Emmanuel A. Theodorakis, Akhil B. Vaidya
Antimicrob Agents Chemother.; 61(1): e01220-16. Prepublished online 2016 Oct 31. Published online 2016 Dec 27. doi: 10.1128/AAC.01220-16, Jan 2017

Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p
Bethany J. Jenkins, Thomas M. Daly, Joanne M. Morrisey, Michael W. Mather, Akhil B. Vaidya, Lawrence W. Bergman
PLoS One.; 11(3): e0152197. Published online 2016 Mar 25. doi: 10.1371/journal.pone.0152197, 2016

"Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria"
Allison M. Stickles, Martin J. Smilkstein, Joanne M. Morrisey, Yuexin Li, Isaac P. Forquer, Jane X. Kelly, Sovitj Pou, Rolf W. Winter, Aaron Nilsen, Akhil B. Vaidya, Michael K. Riscoe
Antimicrob Agents Chemother.; 60(8): 4853–4859. Prepublished online 2016 Jun 6. Published online 2016 Jul 22. doi: 10.1128/AAC.00791-16, Aug 2016

"Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum"
Sudipta Das, Suyash Bhatanagar, Joanne M. Morrisey, Thomas M. Daly, James M. Burns, Jr, Isabelle Coppens, Akhil B. Vaidya
PLoS Pathog.; 12(5): e1005647. Published online 2016 May 26. doi: 10.1371/journal.ppat.1005647, May 2016

"Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy"
Allison M. Stickles, Li-Min Ting, Joanne M. Morrisey, Yuexin Li, Michael W. Mather, Erin Meermeier, April M. Pershing, Isaac P. Forquer, Galen P. Miley, Sovitj Pou, Rolf W. Winter, David J. Hinrichs, Jane X. Kelly, Kami Kim, Akhil B. Vaidya, Michael K. Riscoe, Aaron Nilsen
Am J Trop Med Hyg.; 92(6): 1195–1201. doi: 10.4269/ajtmh.14-0553, Jun 3, 2015

"Inhibition within the Cytochrome bc1 Complex of Plasmodium falciparum"
Allison M. Stickles, Mariana Justino de Almeida, Joanne M. Morrisey, Kayla A. Sheridan, Isaac P. Forquer, Aaron Nilsen, Rolf W. Winter, Jeremy N. Burrows, David A. Fidock, Akhil B. Vaidya, Michael K. Riscoe
Antimicrob Agents Chemother.; 59(4): 1977–1982. Prepublished online 2015 Jan 20. Published online 2015 Mar 11. doi: 10.1128/AAC.04149-14, Apr 2015

"Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle"
Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB.
Cell Rep.;11(1):164-74. doi: 10.1016/j.celrep.2015.03.011. (Epub 2015 Apr 2), Apr 7, 2015

"The Heme Biosynthesis Pathway Is Essential for Plasmodium falciparum Development in Mosquito Stage but Not in Blood Stages"
Hangjun Ke, Paul A. Sigala, Kazutoyo Miura, Joanne M. Morrisey, Michael W. Mather, Jan R. Crowley, Jeffrey P. Henderson, Daniel E. Goldberg, Carole A. Long, Akhil B. Vaidya
J Biol Chem.; 289(50): 34827–34837. Published online 2014 Oct 28. doi: 10.1074/jbc.M114.615831, Dec 12, 2014

"Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum"
Akhil B. Vaidya, Joanne M. Morrisey, Zhongsheng Zhang, Sudipta Das, Thomas M. Daly, Thomas D. Otto, Natalie J. Spillman, Matthew Wyvratt, Peter Siegl, Jutta Marfurt, Grennady Wirjanata, Boni F. Sebayang, Ric N. Price, Arnab Chatterjee, Advait Nagle, Marcin Stasiak, Susan A. Charman, Iñigo Angulo-Barturen, Santiago Ferrer, María Belén Jiménez-Díaz, María Santos Martínez, Francisco Javier Gamo, Vicky M. Avery, Andrea Ruecker, Michael Delves, Kiaran Kirk, Matthew Berriman, Sandhya Kortagere, Jeremy Burrows, Erkang Fan, Lawrence W. Bergman
Nat Commun., 5:5521, Nov 25, 2014

"Quinolone-3-Diarylethers: A new class of drugs for a new era of malaria eradication"
Aaron Nilsen, Alexis N. LaCrue, Karen L. White, Isaac P. Forquer, Richard M. Cross, Jutta Marfurt, Michael W. Mather, Michael J. Delves, David M. Shackleford, Fabian E. Saenz, Joanne M. Morrisey, Jessica Steuten, Tina Mutka, Yuexin Li, Grennady Wirjanata, Eileen Ryan, Sandra Duffy, Jane Xu Kelly, Boni F. Sebayang, Anne-Marie Zeeman, Rintis Noviyanti, Robert E. Sinden, Clemens H. M. Kocken, Ric N. Price, Vicky M. Avery, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Santiago Ferrer, Esperanza Herreros, Laura M. Sanz, Francisco-Javier Gamo, Ian Bathurst, Jeremy N. Burrows, Peter Siegl, R. Kiplin Guy, Rolf W. Winter, Akhil B. Vaidya, Susan A. Charman, Dennis E. Kyle, Roman Manetsch, Michael K. Riscoe
Sci Transl Med. Author manuscript; available in PMC 2014 Nov 11.Published in final edited form as: Sci Transl Med.; 5(177): 177ra37. doi: 10.1126/scitranslmed, Mar 20, 2013

"Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum"
Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB
Mol. Biochem. Parasitol.,;185(1):48-51. doi: 10.1016/j.molbiopara.2012.05.001. (Epub 2012 May 26), Sep 2012

"Branched tricarboxylic acid metabolism in Plasmodium falciparum"
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, and M Llinas
Nature, 469: 432, 2011

"Yeast dihydroorotate dehydrogenase as a new selective marker for Plasmodium falciparum transfection"
Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya KD, Phillips MA, Rathod PK, Mather MW, Vaidya AB
Mol. Biochem. Parasitol. 177:29-34, 2011

"Variations among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain functions"
Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, and AB Vaidya
Eukaryot Cell (epub) June 17, 2011

"ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption"
Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB
J. Biol. Chem. 286, 41312-41322, 2011

"Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum"
Painter HJ, Morrisey JM, and AB Vaidya
Antimicrob. Agents Chemother., 54: 5281-5287, 2010

"Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies"
Mather MW, Morrisey JM, and AB Vaidya.
Molecular and Biochemical Parasitology, 174: 150-153, 2010

"Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum"
Kortagere S, Welsh WJ, Morrisey JM, Daly T, Ejigiri I, Sinnis P, Vaidya AB, and LW Bergman
J. Chem. Inf. Model 50: 840-849, 2010

"Host-parasite interactions revealed by Plasmodium falciparum metabolomics"
Olszewski K, Morrisey JM, Wilinski D, Burns JM, Vaidya AB, Rabinowitz JD, and M Llinas
Cell Host & Microbe, 5, 1-9, 2009

"The validity of mitochondrial dehydrogenases as antimalarial drug targets"
Vaidya AB, Painter HJ, Morrisey JM, and MW Mather
Trends Parisitol., 24(1): 8-9, 2008

Presentations

Abstracts Presented

"The Unusual Tricarboxylic Acid Metabolism in Plasmodium falciparum"
Hangjun Ke, Ian Lewis, Kellen Olszewski, Joanne M. Morrisey, Praveen Balabaskaran Nina, Michael W. Mather, Manuel Llinás, Akhil B. Vaidya
American Society of Tropical Medicine and Hygiene 60th Annual Meeting, Philadelphia, December 4-8, 2011

"Yeast Dihydroorotate Dehydrogenase as a New Selectable Marker in Plasmodium berghei Transfection"
Joanne M. Morrisey, Suresh M. Ganesan, Thomas Daly, Heather J. Painter, Hangjun Ke, Ramesh Gajjar, Pradipsinh K. Rathod, Margaret A. Phillips, Michael W. Mather, and Akhil B. Vaidya
Molecular Parasitology Meeting XXII, Woods Hole, Massachusetts, September 11-15, 2011

"Investigating the essentiality of the heme biosynthesis pathway in blood stage Plasmodium falciparum"
Hangjun Ke, Joanne M. Morrisey, Ian Lewis, Manuel Llinás, Michael Mather, Akhil Vaidya
Molecular Parasitology Meeting XXII, Woods Hole, Massachusetts, September 11-15, 2011

"The type II V-H+-pumping pyrophosphatase of the malaria parasite P. falciparum"
Ramanayake N, Morrisey JM, Harrison M, Kirk K, Saliba KJ, and AB Vaidya
IOCOPA XII 2010

"The glycine cleavage complex, a key player in one carbon metabolism, is not essential in blood stage P. falciparum"
Mather MW, Ganesan SM, Morrisey JM, Ke H, and AB Vaidya.
Molecular Parasitology Meeting 2009

"A complete tricarboxylic acid cycle is not required in P. falciparum blood stage parasites"
Ke H, Mather MW, Ganesan S, Morrisey JM, and AB Vaidya
John Hopkins Parasitology Meeting 2009

"Malate: Quinone oxidoreductase is essential mitochondrial dehydrogenase in blood-stage malaria parasites"
Ganesan SM, Morrisey JM, Mather MW, and AB Vaidya
John Hopkins Cell Biology Meeting 2009.

"A complete TCA cycle is not required in P. falciparum blood stage parasites"
Ke H, Mather MW, Olszewski K, Ganesan SM, Morrisey JM, Llinas M, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Role of mitochondrial dehydrogenases in blood stage malaria parasites"
Ganesan SM, Morrisey JM, Painter HJ, Mather MW, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"The unusual ATP synthase complexes in alveolate protists"
Balabaskaran Nina P, Dudkina N, Kane LA, Morrisey JM, Ke H, van Eyk JE, Boekema E, Mather MW, and ABVaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Mitochondrial functions in malaria parasites during in vivo infection"
Morrisey JM, Ganesan SM, Burns Jr., JM, Mather MW, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Strain specificity in the requirement for mitochondrial electron transport in erythrocytic stage Plasmodium falciparum"
Ke H, Morrisey JM, Mather MW, and AB Vaidya
American Society of Tropical Medicine and Hygiene 57th Annual Meeting, New Orleans, Louisiana, December 7-11, 2008

"Is pyrimidine biosynthesis the only essential role for the electron transport chain in different strains of the malaria parasites Plasmodium falciparum at blood stage?"
Ke H, Morrisey J, Mather M, Painter H, and A Vaidya
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"A putative mitochondrial fission protein in the malaria parasite Plasmodium falciparum"
Balabaskaran Nina P, Ganesan SM, Daly T, Morrisey J, Bergman L, Mather M, and A Vaidya.
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"Investigation of the functions of mitochondrially targeted proteins in malaria parasites"
Ganesan SM, Morrisey JM, Painter HJ, Ke H, Mather MW, and AB Vaidya
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"A putative mitochondrial fission protein in Plasmodium falciparum"
Mather MW, Balabaskaran Nina P, Daly T, Morrisey JM, Bergman LW, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Strain specificity in the requirement for mitochondrial electron transport in erythrocytic stage Plasmodium falciparum"
Ke H, Morrisey JM, Mather MW, Painter HJ, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Type-I dihydroorotate dehydrogenase as a selectable marker for Plasmodium falciparum transfection to investigate mitochondrial functions"
Ganesan SM, Morrisey JM, Painter HJ, Mather MW, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Plasmodium falciparum survival in the presence of mitochondrial inhibition is dependent upon balancing pyrimidine nucleotide pools"
Painter HJ, Morrisey J, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Plasmodium metabolomics reveals a link between parasite-induced hypoarginemia and cerebral malaria"
Olszewski K, Morrisey J, Burns J, Vaidya A, Rabinowitz J, and M Llinas"
JHMRI 2008

"Homoloques of a Human Type II diabetes drug Target in Malaria parasites"
Ke H, Morrisey J, Mather M, and A Vaidya
JHMRI 2008

"Type-I Dihydroorotate dehydrogenase as a selectable marker for Plasmodium falciparum transfection to investigate mitochondrial functions"
Ganesan S, Morrisey J, Painter H, Mather M, and A Vaidya
JHMRI 2008

"Probing the plasmodium metabolome"
Olsewewski K, Rabinowitz J, Morrisey J, Burns J, Vaidya A, and M Llinas
ASMS 2008


Contact Information


Research Office

Department of Microbiology & Immunology
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8502
Fax: 215.848.2271