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Robert Rosenberg

Robert Rosenberg, PhD

Professor of Pharmacology & Physiology


Department: Pharmacology & Physiology

Education

  • PhD, Physiology - Yale University (1985)

Awards & Honors

  • Charles Evans Foundation Award, Marine Biological Laboratory (2013)
  • Gerald Fischbach Award, Marine Biological Laboratory (2013)
  • Teacher-Mentor Award, Society for Neuroscience (2007)
  • Established Investigator, American Heart Association (1990-1995)

Robert L. Rosenberg, PhD, is at Drexel University College of Medicine at Tower Health in West Reading, Pa. He is thread director of the physiology and nutrition threads in the Foundations and Frontiers curriculum for first-year medical students. Previously, he was professor of biology at Earlham College (2009-2021) and professor of pharmacology and cell & molecular physiology at the University of North Carolina School of Medicine (1988-2009). He is interested in the application of active-learning strategies such as team-based learning (TBL) approaches and simulation systems in medical education.

Research Interests

Cellular and molecular neurophysiology, electrophysiology, structures and function of ion channels

Research

Prior to teaching full-time at Drexel, Dr. Rosenberg's research focused on the reconstitution and modulation of voltage-gated calcium channels, the molecular mechanisms of activation and modulation of nicotinic acetylcholine receptors, changes in the expression of voltage-gated ion channels in regenerating spinal cord neurons after injury, and computational modeling of voltage-gated sodium channels.

Publications

Selected Publications

“Protonation state of the selectivity filter of bacterial voltage-gated sodium channels is modulated by ions”
Damjanovic A, Chen AY, Rosenberg RL, Roe DR, Wu X, Brooks BR
Proteins: Structure, Function, and Bioinformatics. 88, 527-539, 2020

“ERIN: A portal to resources for higher education in neuroscience”
Olivo RF, Burdo JR, Calin-Jageman R, Grisham WE, Linden ML, Rosenberg RL, Symonds LL, Thornton JE
J. Undergrad. Neurosci. Educ. 13, A126-A130, 2015

“The α7 nicotinic receptor allosteric modulator, PNU-120596, causes conformational changes in the extracellular ligand binding domain similar to acetylcholine”
Barron SC, McLaughlin JT, See JA, Richards VL, Rosenberg RL
Molec. Pharmacol. 76, 253-263, 2009

“Agonist-driven conformational changes in the inner β-sheet of α7 nicotinic receptors”
McLaughlin JT, Fu J, Rosenberg RL
Molec. Pharmacol. 71, 1312-1318, 2007

“Cell-free expression and functional reconstitution of homo-oligomeric α7 nicotinic acetylcholine receptors into planar lipid bilayers”
Lyford LK, Rosenberg RL
J. Biol. Chem. 274, 25675-25681, 1999

“Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers”
Haack JA, Rosenberg RL
Biophys. J. 66, 1051-1060, 1994

“Cell-free expression of functional Shaker potassium channels”
Rosenberg RL, East JE
Nature. 360, 166-169, 1992

“Calcium channels in planar lipid bilayers: Insights into mechanisms of ion permeation and gating”
Rosenberg RL, Hess P, Reeves JP, Smilowitz H, Tsien RW
Science. 231, 1564-1566, 1986

“Reconstitution of neurotoxin-modulated ion transport by the voltage-regulated sodium channel isolated from the electroplax of Electrophorus electricus”
Rosenberg RL, Tomiko SA, Agnew WS
Proc. Natl. Acad. Sci. USA. 81, 1239-1243, 1984

“Modification of a voltage-gated K+-channel from sarcoplasmic reticulum by a pronase-derived specific endopeptidase”
Miller C, Rosenberg RL
J. Gen. Physiol. 74, 457-478, 1979


Contact Information


West Reading Campus
50 Innovation Way
Wyomissing, PA 19610