Recent Peer-Reviewed Manuscripts
“Status Asthmaticus Gravidus: Emergency and Critical Care Management of Acute Severe Asthma During Pregnancy”
Cairns CB, Kraft M
Immunology and Allergy Clinics of North America 2023 Feb;43(1):87-102
“Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension”
National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network; Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM, Self WH
New England Journal of Medicine 2023 Feb 9;388(6):499-510
“Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study”
Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Sesma AF, Simon V,. Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau RKC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, and the IMPACC study group members
Lancet EBioMedicine 2022;83:104208
“The Making of a Community-Based Medical School Branch Campus: A Study in Healthcare System Dynamics on Medical Education Drexel University College of Medicine at Tower Health, West Reading, Pennsylvania”
Schidlow DV, Restifo K, Cairns CB
The Advisor 2022; 42 (2): 11
“Emergency Medicine Research: 2030 Strategic Goals”
Neumar RW, Blomkalns AL, Cairns CB, D’Onofrio G, Kuppermann N, Lewis RJ, Newgard CD,, O’Neil BJ, Rathlev NK, Rothman RE, Wright DW
Academic Emergency Medicine 2022 Feb;29(2):241-251
“A Target for Increased Mortality Risk in Critically Ill Patients: The Concept of Perpetuity”
Mosier, JM, Fisher JM, Hypes CD, Bedrick EJ, Campbell ES, Lutrick K, Cairns CB
Journal of Clinical Medicine 2021 Sep 2;10(17):3971
“IMmunophenotyping Assessment in a COVID-19 Cohort (NIAID IMPACC): A Prospective Longitudinal Study”
ImmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC) Network
Science Immunology 2021 Aug 10;6(62):eabf3733
“Masking for COVID-19 is Associated with Decreased Emergency Department Visits for Influenza and Respiratory Conditions in Maryland”
Dezman Z, Stryckman B, Zachrison KS, Conrad RM, Marcozzi D, Pimentel L, Samuels-Kalow M, Cairns CB
American Journal of Medicine 2021 Jul 6:S0002-9343(21)00410-1
“Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test”
Tsalik EL Henao R, Montgomery JL, Nawrocki JW, Aydin M, Lydon EC, Ko ER, Petzold E, Nicholson BP, Cairns CB, Glickman SW, Quackenbush E, Kingsmore SF, BAO D, Jaehne AK, Rivers EP, Langley RJ, Fowler VG, McClain MT, Crisp RJ, Ginsburg GS, Burke TW, Hemmert AC, Woods CW
Critical Care Medicine 2021 Oct 1;49(10):1651-1663
“A Patient Reported Approach to Identify Medical Errors and Improve Patient Safety in the Emergency Department”
Glickman SW, Mehrotra A, Shea CM, Mayer C, Strickler J, Pabers S, Larson J, Goldstein B, Mandelkehr L, Cairns CB, Pines JM, Schulman KA
Journal of Patient Safety 2020 Sep;16(3):211-215
“Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock”
Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network
Critical Care Medicine 2020 Oct;48(10):1445-1453
“Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study”
Chen, JT; Roberts, R; Fazzari, MJ; Kashani, K; Qadir, N; Cairns, CB; Mathews, K; Park, P; Khan, A; Gilmore, JF; Brown, ART; Tsuei, B; Handzel, M; Lee Chang, A; Duggal, A; Lanspa, M; Herbert, JT; Martinez, A; Tonna, J; Ammar, MA; Hammond, D; Nazer, LH; Heavner, M; Pender, E; Chambers, L; Kenes, MT; Kaufman, D; Downey, A; Brown, B; Chaykosky, D; Wolff, A; Smith, M; Nault, K; Sevransky, J; Gong, MN; VOLUME-CHASERS Study Group and Society for Critical Care Medicine Discovery Network
Critical Care Medicine 2020 Oct;48(10):1436-1444
“Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients”
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Ginde AA, Brower RG, Caterino JM, Finck L, Banner-Goodspeed VM, Grissom CK, Hayden D, Hough CL, Hyzy RC, Khan A, Levitt JE, Park PK, Ringwood N, Rivers EP, Self WH, Shapiro NI, Thompson BT, Yealy DM, Talmor D
New England Journal of Medicine 2019 Dec 26; 381(26): 2529-2540
“Validation of a host response test to distinguish bacterial and viral infection”
Lydon EC, Henao R, Burke TW, Aydin M, Nicholson BP, Glickman S, Fowler VG, Quackenbush EB, Cairns CB, Kingsmore SF, Jaehne AK, Rivers EP, Langley R, Petzold E, Ko E, McClain MT, Ginsburg GS, Woods CW, Tsalik EL
Lancet EBioMedicine 2019; 48: 453-461
"Impact of Point-of-Care Ultrasound in the Emergency Department on the Outcomes of Critically Ill Patients"
Mosier JM, Stolz U, Milligan R, Roy-Chaudhury A, Lutrick K, Hypes CD, Billheimer D, Cairns CB
Critical Care Medicine Explorations 2019 1(6):e0019.
"Recruitment of Dual Career Academic Medicine Couples"
Putnam CW, DiMarco J, Cairns CB
Academic Medicine 2018 Nov;93(11):1604-1606
"A Randomized Study of Immune Plasma for the Treatment of Severe Influenza"
Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, Shoham S, Deville JG, Feucht E, Feinberg J, Luke T, Ravirakas K, Danko J, O’Neil D, Metcalf JA, King K, Burgess T, Aga E, Lane HC, Hughes MD, Davey RT
Lancet Respir Med. 2017 May 15. pii: S2213-2600(17)30174-1
"A Transformative Approach to Academic Medicine: The Partnership Between the University of Arizona and Banner Health"
Cairns CB, Bollinger K, Garcia JGN
Acad Med. 2017 Jan;92(1):20-22
"Host gene expression classifiers diagnose acute respiratory illness etiology"
Tsalik EL, Henao R, Nichols M, Burke T, Ko ER, McClain MT, Hudson LL, Mazur A, Freeman DH, Veldman T, Langley RJ, Quackenbush EB, Glickman SW, Cairns CB, Jaehne AK, Rivers EP, Otero RM, Zaas AK, Kingsmore SF, Lucas J, Fowler VG, Carin L, Ginsburg GS, Woods CW
Sci Transl Med. 20 Jan 2016: Vol. 8, Issue 322, pp. 322ra1
"Confronting Ethical and Regulatory Challenges of Emergency Care Research with Conscious Patients"
Dickert NW, Brown J, Cairns CB, Eaves-Leanos A, Goldkind S, Kim S, Nichol G, O’Conor K, Scott J, Sinert R, Wendler D, Wright D, Silbergleit R
Ann Emerg Med. 2015 Dec 18. pii: S0196-0644(15)01425-0
"United States Critical Illness and Injury Trials Group–Program for Emergency Preparedness. Development of a Core Clinical Dataset to Characterize Serious Illness, Injuries, and Resource Requirements for Acute Medical Responses to Public Health Emergencies"
Murphy DJ, Rubinson L, Blum J, Isakov A, Bhagwanjee S, Cairns CB, Cobb JP, Sevransky JE
Crit Care Med. 2015 Nov;43(11):2403-8
"Deployable, portable, and temporary hospitals; one state's experience through the years"
Kearns RD, Skarote MB, Peterson J, Stringer L, Alson RL, Cairns BA, Hubble MW, Rich PB, Cairns CB, Runge J, Siler SM, Winslow J, Holmes JH
Am J Disaster Med. 2014; 9(3):195-210
"An integrated transcriptome and expressed variant analysis of sepsis survival and death"
Tsalik EL, Langley RJ, Dinwiddie DL, Miller NA, Yoo B, van Velkinburgh JC, Smith LD, Thiffault I, Jaehne AK, Valente AM, Henao R, Yuan X, Glickman SW, Rice BJ, McClain MT, Carin L, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF
Genome Med. 2014 Nov 26;6(11):111
"The 2012 Derecho: Experiences from the West Virginia Emergency Medical Services and Hospitals Response"
Kearns RD, Wnek SM, Fernandez A, Tucker MA, Wigal MS, Mills MR, Cairns CB, Cairns BA, Zee G
Prehosp Disaster Med. 2014 Sep 18:1-4
"Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis"
Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Bryant Nguyen H, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI
Shock. 2014 Aug;42(2):99-107
"Use of Prehospital 12-Lead Electrocardiography and Treatment Times Among ST-Elevation Myocardial Infarction Patients With Atypical Symptoms"
Cannon AR, Lin L, Lytle B, Peterson ED, Cairns CB, Glickman SW
Acad Emerg Med 2014 Aug;21(8):892-8
"Advanced Burn Life Support for day to day Burn Injury Management and Disaster Preparedness; Stakeholder Experiences and Student Perceptions following 56 ABLS courses"
Kearns RD, Ortiz-Pujols SM, Craig CK, Gusler JR, Skarote MB, Carter J, Link P, Rezak-Alger A, Cairns CB, Lofald D, Holmes JH 4th, Cairns BA
J Burn Care Res. 2014 Aug 27
"A Randomized Trial Exploring the Effect of a Telephone Call Follow-up on Care Plan Compliance Among Older Adults Discharged Home From the Emergency Department"
Biese K, Lamantia M, Shofer F, McCall B, Roberts E, Stearns SC, Principe S, Kizer JS, Cairns CB, Busby-Whitehead J
Acad Emerg Med. 2014 Feb;21(2):188-195
"Hospital bioterrorism planning and burn surge"
Kearns RD, Cairns BA, Holmes JH, Cairns CB, Hultman S, Jones SW, Rich PB, Charles A, Skarote MB, Schnits GL, Myers B
Biosecur Bioterror 2014 Jan-Feb;12(1):20-8
"A systems survey unveils mechanisms of survival and death in community acquired sepsis"
Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Øien NC, Wang M, You J, Wulff J, Thompson JW, Moseley AM, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh L, Massaro AF, Baron RM, Choi AMK, Corey RC, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF:
Sci Transl Med. 2013 Jul 24;5(195):195ra95.
Recent Letters to the Editor and Commentaries
"UA Offers Variety of Resources to Address Employees’ Physical, Emotional Wellbeing"
Cairns CB
Life and Work Connections September 2017; 37: 5: 1
"Women in Medicine: Gender Matters"
Cairns CB
Arizona Physician March 2017: 6-7
"Building Academic Medicine’s Future"
Cairns CB
Sombrero December 2016: 11-12
"The Precision Medicine Initiative at the University of Arizona"
Cairns CB
Sombrero November 2016: 8-9
"Record Year for the University of Arizona College of Medicine"
Cairns CB
Sombrero October 2016: 8-9
"National Institutes of Health Funding of Emergency Care
Research: Feast and Famine?"
Baren J, Cairns CB, Neumar R
Ann Emerg Med 2016 Aug;68(2):172-3
"Shaping the Future of Academic Medicine in Tucson and Across Arizona"
Cairns CB
Sombrero June/July 2016: 6-7