Erol Veznedaroglu, MD, who has served as the Robert A. Groff Chair of Neurosurgery at the College of Medicine since 2015, will serve as interim chair of neurology.
Current Teaching Positions
Course Co-Director, AANS Endovascular hands on clinic for Neurosurgeons (Residents and Fellows), MERI Clinic Memphis TN, 2007-Present
Course Co-Director, AANS Complication Avoidance in Endovascular Neurosurgery Course, 2006-Present
Brain Awareness Week activities sponsored by the Philadelphia Chapter of the Society for Neuroscience, Franklin Science Museum, 2003-Present
Lecturer, Medical Neuroscience ID150, Small Group Clinical Conferences, Jefferson Medical College of Thomas Jefferson University (Course Coordinator: Dr. George Brainard), 2002-present
Lecturer, Medical Neuroscience ID150, Grand Rounds, Endovascular Neurosurgery, Jefferson Medical College of Thomas Jefferson University (Course Coordinator: Dr. George Brainard), 2001-present
Previous Teaching Positions
2014
Faculty, Simulation Based Neurosurgical Training
CNS Annual Meeting, Boston, Mass., Oct. 18, 2014
Co-Director, AANS Mid Level Annual Conference
Las Vegas, Nev. Sept. 2-5, 2014
Co-Director, Introduction to Endovascular Neurosurgery
for Residents
AANS Annual Meeting, San Francisco, Calif., April 5, 2014
2013
Co-Director, Open Vascular Neurosurgery Techniques Course for Residents
MERI Clinic AANS, Memphis, Tenn., Nov. 9-10, 2013
Co-Director, Endovascular Neurosurgery Techniques Course for Residents
MERI Clinic, Memphis, Tenn., Nov. 8-9, 2013
Faculty, Simulation Based Neurosurgical Training
CNS Annual Meeting, San Francisco, Calif., Oct. 20, 2013
Co-Director, Advanced Endovascular Techniques for Fellows AANS/SVIN/SNIS Combined MERI Course, Memphis, Tenn., Oct. 4-7, 2013
Simulation-Based Training for Residents in Cerebral Bypass and Cerebral Angiography
European Association of Neurological Surgeons Annual Meeting,
Prague, Czech Republic, Sept. 25, 2013
Co-Director, Junior Residents' Introduction to Cerebrovascular Neurosurgery Course
AANS Annual Meeting, New Orleans, La., April 27, 2013
Community Outreach Panel
5th Annual Neurosciences Conference, Revel Atlantic City, N.J., April 20, 2013
2012
Director, Endovascular Techniques for Fellows
MERI Course, AANS, Memphis, Tenn., Oct. 19-22, 2012
Director, Endovascular Techniques for Residents
MERI Course, AANS, Memphis, Tenn., Oct. 18-19, 2012
Faculty, Simulation-Based Neurosurgical Training
Congress of Neurological Surgeons, Chicago, Ill., Oct. 7, 2012
Faculty, Junior Fellows Endovascular Course
Mayfield Clinic, Jackson Hole, Wyo., June 16-17, 2012
Co-Director, NeuroNEXT Regional Technology Training for Fellows
MERI Clinic, Memphis, Tenn., April 3-4, 2012
Endovascular Simulation with the Masters Demonstration, Stent-Assisted Coiling of Cerebral Aneurysms
AANS/CNS Cerebrovascular Meeting, New Orleans, La., Jan 30, 2012
Co-Director, Hands on Simulation Course for Fellows
AANS/CNS Cerebrovascular Section Meeting, New Orleans, La., Jan. 28-29, 2012
2011
Simulation-Based Neurosurgical Training
Annual CNS Meeting Practical Course, Washington, D.C., Oct. 2, 2011
Director, Endovascular Techniques for Residents
MERI Course AANS, Memphis, Tenn., Sept. 23-25, 2011
Meeting Chair, Third Annual Cerebrovascular Update Conference for State of New Jersey, Atlantic City, N.J. May 4-5, 2011
Moderator, Advances in Endovascular Treatments
CNS University Webinar, Jan. 27, 2011
Fundamentals of Angiography Resident Course
University of Florida, Gainesville, Fla., Jan 7-8, 2011
2010
Simulator-Based Training in Endovascular Techniques and Nuances
CNS Annual Meeting, San Francisco, Calif., Oct 17, 2010
Residents Hands-on Endovascular Practical Clinic
AANS/CNS Annual Section Meeting, San Antonio, Texas, Feb. 21, 2010
2009 and Earlier
Course Co-Director, Nuances of Cerebrovascular Surgery Hands-on Course
AANS St. Louis University, St. Louis, Mo., July 24-27, 2009
Cordis Endovascular Residents Summit
Miami, Fla., March 4-6, 2009
Course Co-Coordinator, Clinical Mentorship in Neuroscience
College of Graduate Studies, Thomas Jefferson University, 2007-2008
Course Lecturer, Neurosurgery and Neurology Board Review for Residents
Jefferson Medical College of Thomas Jefferson University, 2005-2008
Faculty: Introduction to Endovascular Neurosurgery Hands-on Course
CNS Annual Meeting, Boston, Mass., 2008
Lecturer, Translational Topics in Neuroscience
College of Graduate Studies, Thomas Jefferson University, 2002-2008
Lecturer, Embryology
College of Graduate Studies, Thomas Jefferson University (Course Coordinator: Dr. Gerald Grunwald), 2002-2008
Faculty: Introduction to Endovascular Neurosurgery Simulation Course
CNS, Chicago, Ill., October 7, 2006
Faculty, AANS Endovascular Hands-on Clinic for Neurosurgeons
MERI Clinic, Memphis, Tenn., March 31-April 2, 2006
Coordinator, Endovascular Techniques Clinic
American Association of Neurological Surgeons Meeting, San Diego, Calif., 2003
Teaching Awards
- William A Buchheit Teacher of the Year Award: 2004-2005, 2005-2006, 2006-2007, 2007-2008
- Science Educator Award Society for Neuroscience (2005)
Research
Current Research
Stroke and TIA (mini-stroke)
Prevention
Aspirin and Plavix for Stroke Prevention
Response study: The study is being conducted to find out the effect omega-3 fatty acids have on subject responsiveness to dual-antiplatelet therapy after neuroendovascular stenting and on subject receiving dual antiplatelet therapy for stroke prevention.
Generalizable Knowledge
Impact of Emergency Department Discharge on TIA Rapid Assessment Outcomes: A Prospective Observational 90-Day Follow-Up Study (TIARA)
Veznedaroglu (PI)
This study measures outcomes following TIA to determine the impact standard practices (admission or discharge) on stroke and TIA recurrence.
Long Term Outcomes of Octogenarians with Acute Ischemic Stroke who Receive Endovascular Therapy
Veznedaroglu (PI)
This study will examine the long term outcomes in patients 80 years and above who have had an acute ischemic stroke and have received IV tPA, Heparin, and/or endovascular treatment.
Prehospital Stroke Alert (PHSA)
The primary aim of this study is to determine a decreased time from when the patient arrives to the hospital to when they receive IV tPA by delivering patients directly to CT for imaging, by passing ED triage. Published
Improved Door-to-Needle Times and Neurologic Outcomes When IV Tissue Plasminogen Activator Is Administered by Emergency Physicians with Advanced Neuroscience Training
This study demonstrated improved door to needle times and outcomes in Capital Health specialized neurological emergency department.
Retrospective Study of Heparin Administration for Ischemic Stroke When There Is an IV-tPA Contraindication
Veznedaroglu (PI)
This study will analyze outcomes of patients that receive IV Heparin within 24 hours of symptom onset. The aims of the study are to compare early bleeding complications between patients administered heparin when they presented with contraindication to IV tPA but within 24 hours of ischemic stroke onset and also patient outcomes. Published
CLOT Retrieval
Study looking at the clinical significance of retrieving actual clot vs. not when performing thrombectomy for stroke. We would like to start prospectively collecting data and we will document during the procedure if we visualized a retrieved clot or not then will test the clinical significance. Endpoint Outcome: TICI 2b or better if clot retrieved or not.
Trevo-pro-retreiver in Acute Ischemic Stroke Patients
Veznedaroglu (PI)
Post-market single center analysis. Published
Stroke Incidence with CAS
Veznedaroglu (Co-PI)
A retrospective review of stroke incidence following carotid angioplasty and stenting in carotid stenosis patients.
Emergent Treatment
DAWN–Trial - DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-up and Late Presenting Strokes Undergoing Neuro-intervention
Veznedaroglu (PI)
To evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects experiencing an acute ischemic stroke when treatment is initiated within 6-24 hours after last seen well.
POSITIVE - Perfuson Imaging Selection of Ischemic Stroke Patients for Endovascular Therapy
Veznedaroglu (PI)
The purpose of this randomized trial is to demonstrate the safety and efficacy of mechanical thrombectomy over medical therapy (MT) for treating acute ischemic stroke patients ineligible for IV-tPA with persistent symptoms within a 12 hour time window from symptom onset as selected by physiologic perfusion imaging criteria.
TREVO Registry
Veznedaroglu (Multi-site PI)
Prospective post – market registry of international sites for TREVO device for thrombectomy
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Aneurysm / AVM
Urgent Treatment
FRED
Veznedaroglu (PI)
The purpose of this study is to evaluate the safety and effectiveness of the MicroVention Flow Redirection Intraluminal Device (FRED) system when used in the treatment of wide-necked intracranial aneurysms.
WEAVE Wingspan Stent System Post Market Surveillance Study
Veznedaroglu (PI)
The purpose of this study is to offer the use of Wingspan Stent and Gateway Balloon Catheter devices for treatment of patients with neurovascular disease, including recurrent stroke refractive to medical therapy.
Multi-Center Chart Reviews
CN Deficit Fate After PED Aneurysm Treatment
Veznedaroglu (PI)
Retrospective chart review unruptured intracranial aneurysm presenting with cranial neuropathy and treated with flow diversion.
Endovascular Therapy of Venous Thrombosis
Veznedaroglu (PI)
Evaluate the efficacy of different endovascular devices for the treatment of venous sinus thrombosis.
Endovascular Treatment of Dual Arterio-venous Fistulas: A Retrospective Review Veznedaroglu (PI)
Multicenter Outcomes after Treatment of Unruptured AVMs (ARUBA AVM)
Veznedaroglu (PI)
Review of our data and previous published literature shows that the rate of hemorrhagic strokes treated in ARUBA is significantly higher than previously reported. Our goal in this study to publish our thoughts on the fallacies of ARUBA trial and support it with data of results after interventional from similar cohort of treated unruptured AVMs.
Retrospective Recording and Analysis of Patient Outcomes Following Cyberknife Treatment in Arterio-Venous Malformations (AVM) in the Brain
This study will evaluate AVM treatment protocols and outcomes to ascertain if CyberKnife provides at least the same or better morbidity and mortality rates.
Generalizable Knowledge
Intracranial Aneurysm Treatment and Outcome by Dual-trained Neurosurgeons at a Single Center
Veznedaroglu (PI)
This is a retrospective review of both ruptured and unruptured aneurysm treatments and outcomes by dual trained neurosurgeons at Capital Health System, Inc. hospitals since commencement of neurosurgery. The hypothesis proposes to validate that aneurysm treatment for this patient population has evolved over time and new trends have developed in treatment paradigms.
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Neuro-Oncology
Intra-arterial Avastin
Veznedaroglu (PI/IND holder)
High grade Gliomas in patients with gliobastoma multiforme, we will administer the chemotherapy, avastin, directly into the brain tumor via intra-arterial intracranial delivery. Delivery of chemotherapy directly to the brain tumor is a cutting edge method that may spare the patient the systemic side effects of the chemotherapy and allow for a more concentrated dose of the drug.
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Neurology
PFO Study
Association between atrial arrhythmia and patent foramen ovale (PFO) in ischemic stroke and transient ischemic attack patients.
Predicting Cognitive Improvement in Patients with Normal Pressure Hydrocephalus
Veznedaroglu (Co-PI)
This study aims to identify biomarkers (white matter tracks and tau/ amyloid protein profiles) to predict cognitive response following shunting in NPH patients.
Pyridoxine Levels and Treatment in Refractory Status Epilepticus
This project aims to determine the baseline levels of pyridoxine in patients with status epilepticus and the impact of pyridoxine supplementation on seizure frequency.
Recombinant Factor VIIa Use in Patients Presenting with Intracranial Hemorrhage
The objectives of this study are to review the usage of recombinant factor VIIa at Capital Health for intracranial hemorrhage, evaluate the effectiveness of the doses used and adverse event data in the course of treatment. Published
The Impact of the Endo-vascular Treatment of Cerebral Aneurysms on Headaches and Other Neurological Outcomes
This is a cross sectional, prospective, open label study to examine the impact of the endo-vascular treatment of cerebral aneurysms on headaches and other neurological outcome including seizures and data to day function.
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