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Nikhil S. Seval

Nikhil S. Seval, MD

Assistant Professor

Department: Medicine

Practices: Partnership Comprehensive Care Practice

Specialties: Internal Medicine, Infectious Diseases, HIV


  • MD - Texas A&M Health Science Center College
  • BS - The University of Texas at Austin

Awards & Honors

  • Ruth L. Kirschstein National Research Service Award (2017)
  • Undergraduate Research Fellow (2009)
  • Cockrell Scholar (2005)

Memberships / Professional Affiliations

  • Reviewer, Annals of Thoracic Surgery (2020)
  • Medical Technical Referent, Médecins Sans Frontières (MSF) (2018)

Nikhil S. Seval, MD, is a board certified internist and infectious disease specialist. He sees patients at the Partnership Comprehensive Care Practice in Center City Philadelphia and is also adjunct faculty in infectious diseases at Jefferson University Hospital where he sees inpatient consults. Dr Seval seeks to improve care for all people living with HIV through evidence-based medicine and compassionate patient centered care. His additional interests are in clinical research and in the intersection of infectious diseases with addiction.

Nikhil Seval, MD, is an assistant professor in the Department of Medicine at Drexel University College of Medicine.


Past Grants and Clinical Trials

Title: Addressing risk through Community Treatment for Infectious disease and Opioid use disorder Now (ACTION) among justice-involved populations
Project Period: 9/30/2020-7/31/2025
Agency: NIDA; I.D.#: U01 DA053039
P.I.: Sandra Springer, MD
Role on Project: Co-Investigator

Title: Coordinated medical treatment of opioid use disorder and infectious disease
Project Period: project: 7/18/2019-6/30/2023
Agency: NCATS; I.D.#: U01 TR002763
P.I.: Sandra Springer, MD
Role on Project: Yale Site Medical Director

Protocol IND 119127: Randomized Trial to Prevent Vascular Events in HIV – REPRIEVE (A5332)
Project Period: 2015 - ongoing
PIs: Grinspoon S, Douglas P, Hoffmann U & Ribaudo H
Site PI: Nikhil Seval, MD

Title: A Multi-arm, Phase 3, Randomized, Placebo Controlled, Double Blind Clinical Trial to Investigate the Efficacy and Safety of Fostemsavir (BMS-663068/GSK3684934) in Heavily Treatment Experienced Subjects Infected with Multi-drug Resistant HIV-1
Project Period: 07/1/2015-present
Agency: ViiV Healthcare; I.D.#: ViiV GSK AI438-047/205888
Site PI: Michael Kozal, MD
Role on Project: Site Investigator


Peer-Reviewed Original Research

"Design and methods of a multi-site randomized controlled trial of an integrated care model of long-acting injectable buprenorphine with infectious disease treatment among persons hospitalized with infections and opioid use disorder"
Seval N, Frank CA, Litwin AH, Roth P, Schade MA, Pavlicova M, Levin FR, Brady KT, Nunes EV, Springer SA
Contemp Clin Trials. Apr 7;105:106394. doi: 10.1016/j.cct.2021.106394. Epub ahead of print. (2021)

"The Impact of Medications for Opioid Use Disorder on Hepatitis C Incidence Among Incarcerated Persons: A Systematic Review"
Seval N, Wurcel A, Gunderson CG, Grimshaw A, Springer SA
Infect Dis Clin North Am. 34(3):559-584 (2020)

"Piperacillin-Tazobactam versus Other Antibacterial Agents for Treatment of Bloodstream Infections Due to AmpC β-Lactamase-Producing Enterobacteriaceae"
Cheng L, Nelson BC, Mehta M, Seval N, Park S, Giddins MJ, Shi Q, Whittier S, Gomez-Simmonds A, Uhlemann AC
Antimicrob Agents Chemother. May 24;61(6):e00276-17 (2017)

"The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma"
Wu W, Merriman K, Nabaah A, Seval N, Seval D, Lin H, Wang M, Qazilbash M H, Baladandayuthapani V, Berry D, Orlowski R Z, Lee M H, Yeung S C
British Journal of Cancer 111, 628-636 (2014)

"The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations"
Mitchell D 3rd, Jarmoskaite I, Seval N, Seifert S, Russell R
J Mol Biol. 425(15):2670–86 (2013)

Chapters, Books and Reviews

"Fostemsavir for the treatment of HIV"
Seval N, Frank C, Kozal M
Expert Rev Anti Infect Ther. Jan 4:1-6. doi: 10.1080/14787210.2021.1865801. Epub ahead of print. (2021)

"Inpatient Opioid Use Disorder (OUD) Treatment for the ID Physician"
Seval N, Eaton E, Springer SA
In: Norton B, ed., The Opioid Epidemic and Infectious Diseases. Elsevier. 189-221 (2020)

"Beyond Antibiotics: A Practical Guide for the Infectious Disease Physician to Treat Opioid Use Disorder in the Setting of Associated Infectious Diseases"
Seval N, Eaton E, Springer SA
Open Forum Infect Dis. Dec 24;7(1):ofz539 (2019)

Contact Information

Partnership Comprehensive Care Practice
1427 Vine Street
2nd Floor
Philadelphia, PA 19102
Phone: 215.762.2530
Fax: 215.762.2531