Preprints
"High-Throughput Kinase Inhibitor Screening Reveals Roles for Aurora and Nuak Kinases in Neurite Initiation and Dendritic Branching."
Blazejewski SM, Bennison SA, Liu X. and Toyo-oka K
BioRxiv. 2020.06.25.162271 [Preprint]. June 26, 2020.
"14-3-3 shuttles activity-dependent neuroprotective protein to the cytoplasm to promote appropriate neuronal morphogenesis, cortical connectivity and calcium signaling."
Bennison SA, Blazejewski SM, Liu X and Toyo-oka K
BioRxiv. 2020.05.26.105015 [Preprint]. May 27, 2020
"Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex."
Liu X, Bennison SA, Blazejewski SM and Toyo-oka K
BioRxiv. 2020.01.06.895672 [Preprint]. May 22, 2020
"PEDF-Rpsa-Itga6 signaling regulates cortical neuronal morphogenesis."
Blazejewski SM, Bennison SA, Ha NY, Liu X, Smith TH, Dougherty KJ, and Toyo-oka K
BioRxiv. 2020.01.06.895672 [Preprint]. April 13, 2020
Peer-Reviewed Manuscripts
"Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain."
Deng Y, Jiang B, Rankin CL, Toyo-Oka K, Richter ML, Maupin-Furlow JA, Moskovitz
J. Free Radic Biol Med. 2018, 129: 600-607.
"Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors."
Wachi T, Cornell B and Toyo-oka K
Behav Brain Res, 2017, 319: 31-36.
" In vitro and in vivo Analysis of 14-3-3epsilon and the Regulation of Neuronal Morphogenesis via the Microtubule Binding Protein, Doublecortin."
Cornell B, Wachi T, Zhukarev V and Toyo-oka K
Hum Mole Genet, 2016, 25(20): 4405-4418.
"Overexpression of the 14-3-3Gamma Protein in Embryonic Mice Results in Neuronal Migration Delay in the Developing Cerebral Cortex"
Cornell B, Wachi T, Zhukarev V and Toyo-oka K
Neurosci Lett, in press, doi:10.1016/j.neulet.2016.06.009.
"Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects"
Cornel B and Toyo-oka K
BMC Res Notes, 9(1);180-185, 2016
"Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex"
Wachi T, Cornell B, Marshall C, Zhukarev V, Baas PW, and Toyo-Oka K
Dev Neurobiol., 76 (6): 600-614, 2016
"14-3-3epsilon and zeta Regulate Neurogenesis and Differentiation of Neuronal Progenitor Cells in the Developing Brain""
Toyo-oka K, Wachi T, Hunt RF, Baraban SC, Taya S, Ramshaw H, Kaibuchi K, Schwarz QP, Lopez AF and Wynshaw-Boris A
J Neurosci., 34(36):12168-12181, 2014
"14-3-3{varepsilon} Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle"
Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-Oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ and Brunelli L
Mol. Cell. Biol., 32:5089-5102, 2012
"Neurodevelopmental defects and neuropsychiatric behaviour arise from 14-3-3zeta deficiency"
Cheah PS, Ramshaw HS., Thomas PQ, Toyo-oka K, Martin S, Coyle P, Guthridge MA, Stomski F, van den Buuse M, Wynshaw-Boris A, Lopez AF and Schwarz QP
Mol. Psychiatr., 17:451-466, 2011
"Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia"
Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Osaki N, Kaibuchi K and Iwata N
Hum. Mol. Genet., 17: 3212-3222, 2008
"A Neuroepithelial Stem Cell Proliferation requires LIS1 for Precise Spindle Orientation and Symmetric Division"
Yingling J, Youn YH, Darling D, Toyo-oka K, Pramparo T, Hirotsune S and Wynshaw-Boris
Cell, 132: 474-486, 2008
"Protein Phosphatase4 catalytic subunit (PP4c) regulates CDK1 activity and organization of microtubules through dephosphorylation of NDEL1"
Toyo-oka K, Yano Y, Shiota M, Iwao H, Hiraiwa N, Muramatsu M, Yoshiki A and Hirotsune S
J Cell Biol., 180: 1133-1147, 2008
"NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 recruitment"
Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A and Hirotsune S
Mol. Cell. Biol., 27: 352-367, 2007
"Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression"
Toyo-oka K, Bowen TJ, Hirotsune S, Li Z, Jain S, Ota S, Lozach LE, Bassett IG, Lozach J, Rosenfeld MG, Glass CK, Eisenman R, Ren B, Hurlin PJ and Wynshaw-Boris A
Cancer Res., 66: 5565-5573, 2006
"Recruitment of katanin P60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration"
Toyo-oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima YY, Tokuoka SM, Ishii S, Shimizu T, Muramatsu M, Hiraiwa N, Yoshiki A, Wynshaw-Boris A and Hirotsune S
Hum. Mol. Genet., 14: 3113-3128, 2005
"Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality"
Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, and Hirotsune A
Mol. Cell. Biol., 25:7812-7827, 2005
"Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome"
Toyo-oka K, Hirotsune S, Gambello MJ, Zhou Z-Q, Olson L, Rosenfeld MG, Eisenman R, Hurlin PJ and Wynshaw-Boris A
Hum. Mol. Genet., 13:1057-1067, 2004
"Evidence of Mnt-Myc Antagonism Revealed by Mnt Gene Deletion"
Hurlin PJ, Zhou Z-Q, Toyo-oka K, Ota S, Walker WL, Hirotsune S and Wynshaw-Boris A
Cell Cycle, 3:97-99, 2004
"Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis"
Hurlin PJ, Zhou Z-Q, Toyo-oka K, Ota S, Walker WL, Hirotsune S and Wynshaw-Boris A
EMBO J., 22:4584-4596, 2003
"14-3-3epsilon is important for neuronal migration via binding of NUDEL : a molecular explanation for Miller-Dieker syndrome"
Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai L-H, Dobyns W, Ledbetter D, Hirotsune S and Wynshaw-Boris A
Nat. Genet., 34:274-285, 2003
"Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3"
Cardoso C, Leventer RJ, Ward HL, Toyo-oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB and Ledbetter DH
Am. J. Hum. Genet., 72:918-930, 2003
Reviews
"Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration."
Bennison SA, Blazejewski SM, Smith TH, Toyo-oka K
Cell Mol Life Sci. (2019) Oct 28. doi: 10.1007/s00018-019-03336-6
"Neurodevelopmental Genetic Diseases Associated with Microdeletions and Microduplications of Chromosome 17p13.3"
Blajezewski SM, Bennison SA, Smith TH and Toyo-oka K
Front. Genet. 9:80 (2018) doi: 10.3389/fgene.2018.00080
"14-3-3 proteins in brain development: neurogenesis, neuronal migration and neuromorphogenesis."
Cornell B and Toyo-oka K
Front. Mol. Neurosci, 2017, 12 October 2017, https://doi.org/10.3389/fnmol.2017.00318v
"Novel Functions of 14-3-3 Proteins in Neurogenesis and Neuronal Differentiation In Vivo."
Wachi T and Toyo-oka K
Ther Targets Neurol Dis (Therapeutic targets for neurological diseases), 2015, 2(1), doi: 10.14800/ttnd.500
"Miller-Dieker Syndrome: Analysis of a Human Contiguous Gene Syndrome in the Mouse"
Yingling J, Toyo-oka K, and Wynshaw-Boris A
Am. J. Hum. Genet., 73(3):475-488, 2003