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Simon Danner

Simon Danner, PhD

Assistant Professor


Department: Neurobiology & Anatomy

Education

  • Doctorate in Engineering Sciences - Vienna University of Technology (2013)
  • MSocEcSc in Computer Science Management - Vienna University of Technology (2011)
  • MSc in Medicine and Computer Science - Vienna University of Technology (2010)
  • BSc in Medicine and Computer Science - Vienna University of Technology (2008)

Awards & Honors

  • Reviewer of the year, Journal of Neural Engineering, IOP Publishing, Bristol, U.K. (2019)
  • Visiting scholarship (selected by competition), National Center for Simulation in Rehabilitation Research (NCSRR), Stanford University, Stanford, California, July 16–August 15, 2018
  • Best poster award (1st prize), travel award, and Drexel International Travel Award for the 14th Karniel Computational Motor Control Workshop, Beersheba, Israel (Mar. 13–15, 2018)
  • Researcher of the Month, Medical University of Vienna (March 2016)
  • Young Investigator Award, Austrian Society for Biomedical Engineering (2015)
  • Best poster award (1st prize) and travel award, 2nd Annual Minnesota Neuromodulation Symposium (2014)
  • First prize, student competition, Biomedizinische Technik (2013)
  • Travel award, 22nd Annual Computational Neuroscience Meeting (2013)
  • Graduate student travel award, Cellular and Network Functions in the Spinal Cord (2012)
  • Advancement award, best master thesis presentation, Austrian Society for Biomedical Engineering at the Medizinische Physik (2011)

Memberships / Professional Affiliations

  • TU-BIOMED
  • International Society for Restorative Neurology
  • Society for Neuroscience
  • Organization for Computational Neuroscience
  • Austrian Society for Biomedical Engineering
  • IEEE

Simon M. Danner, PhD, is an assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine.

Research Overview

Research Interests

Computational modeling of neural control of locomotion

Publications

Publications in Peer-Reviewed Journals

"On the organization of the locomotor CPG: insights from split-belt locomotion and mathematical modeling"
Latash EM, Lecomte CG, Danner SM, Frigon A, Rybak IA and Molkov YI
Frontiers in Neuroscience, 14, 598888. doi: 10.3389/fnins.2020.598888. Preprint: bioRxiv 2020.07.17.205351. doi: 10.1101/2020.07.17.205351 (2020)

"Transcutaneous spinal cord stimulation induces temporary attenuation of spasticity in individuals with spinal cord injury"
Hofstoetter US, Freundl B, Danner SM, Krenn MJ, Mayr W, Binder H and Minassian K
Journal of Neurotrauma, 37(3), 481–493. doi: 10.1089/neu.2019.6588 (2020)

"Phase-dependent response to afferent stimulation during fictive locomotion: a computational modeling study"
Fujiki S, Aoi S, Tsuchiya K, Danner SM, Rybak IA and Yanagihara D
Frontiers in Neuroscience, 13, 1288. doi: 10.3389/fnins.2019.01288 (2019)

"Spinal V3 interneurons and left-right coordination in mammalian locomotion"
Danner SM, Zhang H, Shevtsova NA, Borowska-Fielding J, Deska-Gauthier D, Rybak IA and Zhang Y
Frontiers in Cellular Neuroscience 13, 516. doi: 10.3389/fncel.2019.00516. Preprint: bioRxiv, 679654. doi: 10.1101/679654 (2019)

"Computational modeling of brainstem circuits controlling locomotor frequency and gait"
Ausborn J, Shevtsova NA, Caggiano V, Danner SM and Rybak IA
eLife 8, e43587. doi: 10.7554/eLife.43587 (2019)

“Intralimb and interlimb cutaneous reflexes during locomotion in the intact cat”
Hurteau M-F, Thibaudier Y, Dambreville C, Danner SM, Rybak IA and Frigon A
The Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.3288-17.2018 (2018)

"Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds"
Danner SM, Shevtsova NA, Frigon A and Rybak IA
eLife 6, e31050. DOI: 10.7554/eLife.31050 (2017)

"Central control of interlimb coordination and speed-dependent gait expression in quadrupeds"
Danner SM, Wilshin SD, Shevtsova NA and Rybak IA
The Journal of Physiology 594(23), 6947–6967. DOI: 10.1113/JP272787 (2016)

"Spinal rhythm generation by step-induced feedback and transcutaneous posterior root stimulation in complete spinal cord-injured individuals"
Minassian K, Hofstoetter US, Danner SM, Mayr W, Bruce JA, McKay WB and Tansey KE
Neurorehabilitation & Neural Repair 30(3), 233–243. DOI: 10.1177/1545968315591706 (2016)

"Body position influences which neural structures are recruited by lumbar transcutaneous spinal cord stimulation"
Danner SM, Krenn M, Hofstoetter US, Toth A, Mayr W and Minassian K
PLoS ONE 11(1), e0147479. DOI: 10.1371/journal.pone.0147479 (2016)

"Neurocontrol of movement in humans with spinal cord injury"
Dimitrijevic MR, Danner SM and Mayr W
Artificial Organs 39 (10), 823–833. DOI: 10.1111/aor.12614 (2015)

"Augmentation of voluntary locomotor activity by transcutaneous spinal cord stimulation in motor-incomplete spinal cord injured individuals"
Hofstoetter US, Krenn M, Danner SM, Hofer C, Kern H, McKay WB, Mayr W and Minassian K
Artificial Organs 39 (10), E176–E186. DOI: 10.1111/aor.12615 (2015)

"Multi-electrode array for transcutaneous lumbar posterior-root stimulation"
Krenn M, Hofstoetter US, Danner SM, Minassian K and Mayr W
Artificial Organs 39 (10), 834–840. DOI: 10.1111/aor.12616 (2015)

"Periodic modulation of repetitively elicited monosynaptic reflexes of the human lumbosacral spinal cord"
Hofstoetter US, Danner SM, Freundl B, Binder H, Mayr W, Rattay F and Minassian K
Journal of Neurohysiology 114 (1), 400–410. DOI: 10.1152/jn.00136.2015 (2015).

"Human spinal locomotor control is based on flexibly organized burst generators"
Danner SM, Hofstoetter US, Freundl B, Binder H, Mayr W, Rattay F and Minassian K
Brain 138 (3), 577–588. DOI: 10.1093/brain/awu372 (2015)

"Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: evidence from computer modeling"
Rattay F and Danner SM
Hearing Research, 315, 67–79. DOI: 10.1016/j.heares.2014.07.001 (2014)

"Health-related and legal interventions: A comparison of allegedly delinquent and convicted opioid addicts in Austria"
Kochl B, Danner SM, Jagsch R, Brandt L and Fischer G
Drug Science, Policy and Law 1, 2050324514528449. DOI: 10.1177/2050324514528449 (2014)

"Energy-optimal electrical-stimulation pulses shaped by the least-action principle"
Krouchev NI, Danner SM, Vinet A, Rattay F and Sawan M
PLoS ONE 9 (3), e90480. DOI: 10.1371/journal.pone.0090480 (2014)

"Pattern generating networks in the human lumbar spinal cord: electrophysiology and computer modeling"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4012 (2013)

"Effects of transcutaneous spinal cord stimulation on voluntary locomotor activity in an incomplete spinal cord injured individual"
Hofstoetter US, Hofer C, Kern H, Danner SM, Mayr W, Dimitrijevic MR and Minassian, K
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4014 (2013)

"Mechanisms of rhythm generation of the human lumbar spinal cord in response to tonic stimulation without and with step-related sensory feedback"
Minassian K, Hofstoetter US, Danner SM, Mayr W., McKay WB, Tansey K and Dimitrijevic MR
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4013 (2013)

"Selectivity of transcutaneous stimulation of lumbar posterior roots at different spinal levels in humans"
Krenn M, Toth A, Danner SM, Hofstoetter US, Minassian K and Mayr W  
Biomedizinische Technik/Biomedical Engineering 58(Suppl1). DOI: 10.1515/bmt-2013-4010 (2013)

"Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study"
Danner SM, Hofstoetter US, Ladenbauer J, Rattay F and Minassian K
Artificial Organs 35 (3), 257–262. DOI: 10.1111/j.1525-1594.- 2011.01213.x (2011)

Books/Chapters

"Finite Element Models of Transcutaneous Spinal Cord Stimulation"
Danner SM, Hofstoetter US and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 1197-1202, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8 604 (2015)

"Finite element modeling for extracellular stimulation"
Rattay F, Danner SM, Hofstoetter US and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 1186-1195, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8_593 (2015)

"Paraspinal magnetic and transcutaneous electrical stimulation"
Hofstoetter US, Danner SM and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 2194-2212, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8 603 (2015)

Electrical stimulation of myelinated axons: An interactive tutorial supported by computer simulation
Danner SM, Wenger C and Rattay F (eds.)
Saarbrüucken: VDM Verlag (2011).

Transcutaneous electrical spinal cord stimulation: Biophysics of a new rehabilitation method after spinal cord injury.
Száva Z, Danner SM and Minassian K (eds.)
Saarbrücken: VDM Verlag (2011)

Assistant editor, Restorative neurology of spinal cord injury
Dimitrijevic MR, Kakulas BA, McKay WB and Vrbova G (eds.)
New York: Oxford University Press (2011)

Presentations

Invited Lectures

"Spinal circuits for sensorimotor integration during locomotion at different speeds: A computational model"
Danner SM
Virtual Workshop on Motor Control, Oct. 26–29, Online (2020)

"Spinal circuits for sensorimotor integration and limb coordination during locomotion at different speeds"
Danner SM
Vienna Workshop on Computational Neuroscience and Neural Engineering, Aug. 28., Vienna, Austria (2019)

"Human spinal locomotor control is based on flexibly organized burst generators"
Danner SM
ÖGBMT Jahrestagung 2015, Oct. 9–10, Vienna, Austria (2015)

"Human lumbar locomotor networks: neurophysiology and computer modeling"
Danner SM
Departmental seminar, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania (2015)

"Mathematical models of the human locomotor network"
Danner SM
APOSM 2014 & ISRN, November 28-30, Taipei, Taiwan (2014)

"Modelling locomotor pattern generating networks of the human lumbar spinal cord"
Danner SM, Rattay F, Hofstoetter US, Mayr W and Minassian K
In Zidar, J. (ed.). International Symposium on Spasticity and Neural Control of Movement with the 30th Dr. Janez Faganel Memorial Lecture, Sept. 4-6, Ljubljana, Slovenia, 30-31, Section for Clinical Neurophysiology of the Slovenian Medical Association (2014)

"Locomotor rhythm and pattern generating networks of the human lumbar spinal cord: Computer modeling study"
Danner SM
Workshop on recent advances in the pathophysiology and neurorehabilitation of spinal lesions, April 13, Trieste, Italy (2013)

Recent Conference Abstracts

"Effects of developmental dystonia and autism on the development of the locomotor function in mice"
Tran Q, Tawfik A, Thurman CM, Janey E, Dooley JC, Sokoloff G, Rybak IA, Blumberg M and Danner SM
Discovery Day 2020, Oct. 8, Philadelphia, Pennsylvania (2020)

"Central control of speed- dependent gait expression in intact rats and following spinal cord injury"
Danner SM, Shepard CT, Rybak IA and Magnuson DSK
Neuroscience 2019, Oct. 19–23, Chicago, Illinois (2019)

"The role of spinal V3 interneurons in left-right coordination of locomotor activity"
Shevtsova NA, Zhang H, Danner SM, Rybak IA and Zhang Y
Neuroscience 2019, Oct. 19–23, Chicago, Illinois (2019)

"Cats stepping on a split-belt treadmill reveal a special organization of commissural interactions within the spinal locomotor circuits"
Molkov YI, Latash EM, Barnett WH, Capps RH, Danner SM, Frigon A and Rybak IA
Neuroscience 2019, Oct. 19–23, Chicago, Illinois (2019)

"Interactions between spinal circuits and afferent feedback to control locomotion at different speeds: A computational modeling study"
Danner SM, Aoi S, Fujiki S, Markin SN, Akay T, Yanagihara D and Rybak IA
In Ijspeert A: 9th International Symposium on Adaptive Motion of Animals and Machines (AMAM 2019), August. 20–23. Lausanne, Switzerland: EPFL. doi: 10.5075/epfl- BIOROB-AMAM019-13 (2019)

"An integrated neuro-biomechanical model of the mouse to study neural control of locomotion"
Ramalingasetty ST, Danner SM, Ijspeert A and Rybak IA
In Ijspeert A: 9th International Symposium on Adaptive Motion of Animals and Machines (AMAM 2019), August. 20–23. Lausanne, Switzerland: EPFL. doi: 10.5075/epfl-BIOROB-AMAM019-52 (2019)

"Interlimb coordination during split-belt locomotion: A modeling study"
Latash EM, Barnett WH, Capps RA, Danner SM, Rybak IA and Molkov YI
28th Annual Computational Neuroscience Meeting: CNS*2019, July 13–17, Barcelona, Spain (2019)

"Computational modeling of brainstem-spinal circuits controlling locomotor speed and gait"
Rybak IA, Ausborn J, Danner SM and Shevtsova NA
28th Annual Computational Neuroscience Meeting: CNS*2019, July 13–17, Barcelona, Spain (2019)

"Interactions between spinal circuits and afferent feedback to control locomotion at different speeds: Insights from computational modeling"
Danner SM, Aoi S, Fujiki S, Yanagihara D and Rybak IA
Neuroscience 2018, Nov. 3–7, San Diego, California (2018)

"Computational modeling investigation of phase-dependent responses of spinal motoneurons to afferent stimulation during fictive locomotion"
Fujiki S, Aoi S, Danner SM, Rybak IA and Yanagihara D
Neuroscience 2018, Nov. 3–7, San Diego, California (2018)

"Computational modeling of brainstem circuits controlling locomotor speed and gait selection"
Shevtsova NA, Caggiano V, Ausborn J, Danner SM and Rybak IA
Neuroscience 2018, Nov. 3– 7, San Diego, California (2018)

"Interactions between spinal circuits and afferent feedback to control locomotion at different speeds: Insights from computational modeling"
Danner SM, Aoi S, Fujiki S, Yanagihara D and Rybak IA
Motor Systems Symposium 2018, Nov. 2, San Diego, California (2018)

"Computational modeling of brainstem circuits controlling locomotor speed and gait"
Ausborn J, Shevtsova NA, Caggiano V, Danner S M. and Rybak IA
Motor Systems Symposium 2018, Nov. 2, San Diego, California (2018)

"Spinal interneurons and locomotor speed and gait control in quadrupeds"
Rybak IA, Danner SM and Shevtsova NA
CNS 2018, July 13–18, Seattle, Washington (2018)

"Spinal circuits controlling interlimb coordination and speed-dependent gait expression"
Danner SM, Shevtsova NA and Rybak IA
14th Karniel Computational Motor Control Workshop, March 13–15, Beersheba, Israel (2018)

"Computational modeling study of the role of long propriospinal neurons in speed-dependent gait expression"
Danner SM, Shevtsova NA and Rybak IA
Neuroscience 2017, Nov. 11–15, Washington, D.C. (2017)

"Computational modeling of interactions between cervical and lumbar CPG circuits in the rodent spinal cord in vitro"
Shevtsova NA, Danner SM and Rybak IA
Neuroscience 2017, Nov. 11– 15, Washington, D.C. (2017)

"Spinal circuits controlling speed-dependent gait expression in quadrupeds: insights from computational modeling"
Danner SM, Wilshin SD, Bellardita C, Shevtsova NA, Kiehn O and Rybak IA
Neuroscience 2016, November 12–16, San Diego, California (2016)

"Comparative modeling of spinal mechanisms for speed-dependent gait transitions in quadrupeds"
Danner SM, Shevtsova NA and Rybak IA
Motor Systems Symposium, November 11, San Diego, California (2016)

"The role of commissural interneurons in speed-dependent changes of inter-limb coordination and locomotor gait: insights from computational modeling"
Danner SM, Shevtsova NA and Rybak IA
Pre-meeting on Rhythmic Motor Circuits, Oct. 16, Chicago, Illinois (2015)

"Variation of the stimulation site changes the excitation of the lumbosacral spinal reflexes"
Krenn M, Danner SM, Vargas-Luna JL, Toth A, Hofstoetter US, Minassian K and Mayr W
Progress in Motor Control X, July 22-25, Budapest, Hungary (2015)

"Comparison of cathodic and anodic transspinal electrical stimulation to evoke posterior root-muscle reflexes"
Vargas-Luna JL, Krenn M, Danner SM, Hofstoetter US, Minassian K, Mayr W and Helgason T
Progress in Motor Control X, July 22-25, Budapest, Hungary (2015)

"Long-latency spinal reflexes predict rhythmicity in response to epidural lumbar cord stimulation"
Danner SM, Dimitrijevic MR, Hofstoetter US, Krenn M, Mayr W, Minassian, K, Rattay F and Rothwell JC
Neuroscience 2014, Nov. 15-19, Washington, D.C. (2014)

"Short- and long-term effects of intermittent transcutaneous spinal cord stimulation on spinal spasticity and residual motor control"
Hofstoetter US, Krenn M, Danner SM, Freundl B, Binder H, Rattay F, Mayr W and Minassian K
Neuroscience 2014, Nov. 15-19, Washington, D.C. (2014)

"Altering spinal cord excitability by peripheral nerve stimulation"
Krenn M, Danner SM, Schlaff C, Hofstoetter US, Minassian K, Mayr W and Dimitrijevic MR
Neuroscience 2014, Nov. 15-19, Washington, D.C. (2014)

"Health-related and legal interventions: A comparison of allegedly delinquent and convicted opioid addicts in Austria"
Kochl B, Danner SM, Jagsch R, Brandt L and Fischer G
The 17th EASAR Conference, May 15-17, Luneburg, Germany (2014)

"Motor behavior of the human lumbar spinal cord network responding to externally controlled activity: A neurophysiological study"
Danner SM, Dimitrijevic MR, Hofstoetter US, Krenn M, Mayr W, Minassian K, Rattay F and Rothwell JC
2nd Minnesota Neuromodulation Symposium, April 10-11, Minneapolis, Minnesota (2014)

"Modeling locomotor pattern generating networks of the human lumbar spinal cord"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Epidural stimulation of the human lumbar spinal cord can elicit characteristic tonic motor outputs"
Dimitrijevic MR, Hofstoetter US, Mayr W, Minassian K, Rattay F and Danner SM
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Alternating modulations of posterior root-muscle reflexes of the human lumbosacral spinal cord: Inhibitory circuits outside the lumbar locomotor pattern generator"
Hofstoetter US, Minassian K, Danner SM, Rattay F and Dimitrijevic MR
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Central rhythm and pattern generating capabilities of the human lumbar spinal cord"
Minassian K, Danner SM, Hofstoetter US, Rattay F and Dimitrijevic MR
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Selectivity of transcutaneous lumbar spinal cord stimulation for eliciting posterior root-muscle reflexes in humans"
Krenn M, Toth A, Danner SM, Hofstoetter US, Minassian K and Mayr W
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Segmental and plurisegmental processing capabilities of the human lumbar cord isolated from brain motor control"
Danner SM and Dimitrijevic MR
52nd Annual Scientific Meeting of ISCOS, October 28-30, Istanbul, Turkey (2013)

"Neurophysiology model of the human lumbar cord separated from brain control by traumatic injury"
Danner SM, McKay WB, Minassian K, Hofstoetter US, Mayr W, Rattay F and Dimitrijevic MR
SiNAPSA Neuroscience Conference '13 (SNC'13), September 27-29, Ljubljana, Slovenia (2013)

"Electrophysiology of posterior roots-muscle reflex of the human lumbosacral cord"
Krenn M, Minassian K, Hofstoetter US, Danner SM, Dimitrijevic MR and Mayr W
SiNAPSA Neuroscience Conference '13 (SNC'13), September 27-29, Ljubljana, Slovenia (2013)

"Locomotor rhythm and pattern generating networks of the human lumbar spinal cord: an electrophysiological and computer modeling study"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
22nd Annual Computational Neuroscience meeting: CNS*2013, July 13-18, Paris, France. BMC Neuroscience, 14 (Suppl 1), P274. DOI: 10.1186/1471-2202-14-S1-P274 (2013)

"Non-invasive spinal cord stimulation and assisted treadmill stepping to generate rhythmic activities in motor complete spinal cord injured people"
Mayr W, Danner SM, Hofstoetter US, Krenn M, Minassian K, Tansey K, Freundl B and Binder H
Wings for Life scientific meeting, April 23-24, Salzburg, Austria (2013)


Contact Information


Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8507
Fax: 215.843.9082