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Simon Danner

Simon Danner, PhD

Research Instructor


Department: Neurobiology & Anatomy

Education

  • Doctorate in Engineering Sciences - Vienna University of Technology (2013)
  • MSocEcSc in Computer Science Management - Vienna University of Technology (2011)
  • MSc in Medicine and Computer Science - Vienna University of Technology (2010)
  • BSc in Medicine and Computer Science - Vienna University of Technology (2008)

Awards & Honors

  • Best poster award (1st prize), travel award, and Drexel International Travel Award for the 14th Karniel Computational Motor Control Workshop, Beersheba, Israel (Mar. 13–15, 2018)
  • Researcher of the Month, Medical University of Vienna (March 2016)
  • Young Investigator Award, Austrian Society for Biomedical Engineering (2015)
  • Best poster award (1st prize) and travel award, 2nd Annual Minnesota Neuromodulation Symposium (2014)
  • First prize, student competition, Biomedizinische Technik (2013)
  • Travel award, 22nd Annual Computational Neuroscience Meeting (2013)
  • Graduate student travel award, Cellular and Network Functions in the Spinal Cord (2012)
  • Advancement award, best master thesis presentation, Austrian Society for Biomedical Engineering at the Medizinische Physik (2011)

Memberships / Professional Affiliations

  • TU-BIOMED
  • International Society for Restorative Neurology
  • Society for Neuroscience
  • Organization for Computational Neuroscience
  • Austrian Society for Biomedical Engineering
  • IEEE

Simon M. Danner, PhD, is a research instructor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. Prior to coming to Drexel for his postdoctoral fellowship in 2015, he served as a postdoc and then a lecturer at Vienna University of Technology, Institute for Analysis and Scientific Computing and at the Medical University of Vienna, Center for Medical Physics and Biomedical Engineering.

Research Overview

Dr. Danner is a member of the Laboratory for Theoretical and Computational Neuroscience at Drexel University College of Medicine. His main research interest is the computational modeling of the spinal neural networks that control locomotion. In his previous research at the Medical University of Vienna and the Vienna University of Technology, Dr. Danner used spinal cord stimulation to investigate the human spinal locomotor circuits and studied its application to alleviate various sequelae of traumatic spinal cord injury.

Research Interests

Computational modeling of neural control of locomotion

Publications

Publications in Peer-Reviewed Journals

“Intralimb and interlimb cutaneous reflexes during locomotion in the intact cat”
Hurteau M-F, Thibaudier Y, Dambreville C, Danner SM, Rybak IA and Frigon A
The Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.3288-17.2018 (2018)

"Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds"
Danner SM, Shevtsova NA, Frigon A and Rybak IA
eLife 6, e31050. DOI: 10.7554/eLife.31050 (2017)

"Central control of interlimb coordination and speed-dependent gait expression in quadrupeds"
Danner SM, Wilshin SD, Shevtsova NA and Rybak IA
The Journal of Physiology 594(23), 6947–6967. DOI: 10.1113/JP272787 (2016)

"Spinal rhythm generation by step-induced feedback and transcutaneous posterior root stimulation in complete spinal cord-injured individuals"
Minassian K, Hofstoetter US, Danner SM, Mayr W, Bruce JA, McKay WB and Tansey KE
Neurorehabilitation & Neural Repair 30(3), 233–243. DOI: 10.1177/1545968315591706 (2016)

"Body position influences which neural structures are recruited by lumbar transcutaneous spinal cord stimulation"
Danner SM, Krenn M, Hofstoetter US, Toth A, Mayr W and Minassian K
PLoS ONE 11(1), e0147479. DOI: 10.1371/journal.pone.0147479 (2016)

"Neurocontrol of movement in humans with spinal cord injury"
Dimitrijevic MR, Danner SM and Mayr W
Artificial Organs 39 (10), 823–833. DOI: 10.1111/aor.12614 (2015)

"Augmentation of voluntary locomotor activity by transcutaneous spinal cord stimulation in motor-incomplete spinal cord injured individuals"
Hofstoetter US, Krenn M, Danner SM, Hofer C, Kern H, McKay WB, Mayr W and Minassian K
Artificial Organs 39 (10), E176–E186. DOI: 10.1111/aor.12615 (2015)

"Multi-electrode array for transcutaneous lumbar posterior-root stimulation"
Krenn M, Hofstoetter US, Danner SM, Minassian K and Mayr W
Artificial Organs 39 (10), 834–840. DOI: 10.1111/aor.12616 (2015)

"Periodic modulation of repetitively elicited monosynaptic reflexes of the human lumbosacral spinal cord"
Hofstoetter US, Danner SM, Freundl B, Binder H, Mayr W, Rattay F and Minassian K
Journal of Neurohysiology 114 (1), 400–410. DOI: 10.1152/jn.00136.2015 (2015).

"Human spinal locomotor control is based on flexibly organized burst generators"
Danner SM, Hofstoetter US, Freundl B, Binder H, Mayr W, Rattay F and Minassian K
Brain 138 (3), 577–588. DOI: 10.1093/brain/awu372 (2015)

"Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: evidence from computer modeling"
Rattay F and Danner SM
Hearing Research, 315, 67–79. DOI: 10.1016/j.heares.2014.07.001 (2014)

"Health-related and legal interventions: A comparison of allegedly delinquent and convicted opioid addicts in Austria"
Kochl B, Danner SM, Jagsch R, Brandt L and Fischer G
Drug Science, Policy and Law 1, 2050324514528449. DOI: 10.1177/2050324514528449 (2014)

"Energy-optimal electrical-stimulation pulses shaped by the least-action principle"
Krouchev NI, Danner SM, Vinet A, Rattay F and Sawan M
PLoS ONE 9 (3), e90480. DOI: 10.1371/journal.pone.0090480 (2014)

"Pattern generating networks in the human lumbar spinal cord: electrophysiology and computer modeling"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4012 (2013)

"Effects of transcutaneous spinal cord stimulation on voluntary locomotor activity in an incomplete spinal cord injured individual"
Hofstoetter US, Hofer C, Kern H, Danner SM, Mayr W, Dimitrijevic MR and Minassian, K
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4014 (2013)

"Mechanisms of rhythm generation of the human lumbar spinal cord in response to tonic stimulation without and with step-related sensory feedback"
Minassian K, Hofstoetter US, Danner SM, Mayr W., McKay WB, Tansey K and Dimitrijevic MR
Biomedizinische Technik/Biomedical Engineering 58(Suppl 1). DOI: 10.1515/bmt-2013-4013 (2013)

"Selectivity of transcutaneous stimulation of lumbar posterior roots at different spinal levels in humans"
Krenn M, Toth A, Danner SM, Hofstoetter US, Minassian K and Mayr W  
Biomedizinische Technik/Biomedical Engineering 58(Suppl1). DOI: 10.1515/bmt-2013-4010 (2013)

"Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study"
Danner SM, Hofstoetter US, Ladenbauer J, Rattay F and Minassian K
Artificial Organs 35 (3), 257–262. DOI: 10.1111/j.1525-1594.- 2011.01213.x (2011)

Books/Chapters

"Finite Element Models of Transcutaneous Spinal Cord Stimulation"
Danner SM, Hofstoetter US and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 1197-1202, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8 604 (2015)

"Finite element modeling for extracellular stimulation"
Rattay F, Danner SM, Hofstoetter US and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 1186-1195, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8_593 (2015)

"Paraspinal magnetic and transcutaneous electrical stimulation"
Hofstoetter US, Danner SM and Minassian K
In: Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), 2194-2212, Jaeger D, Jung R (Eds.)
New York: Springer. DOI: 10.1007/978-1-4614-6675-8 603 (2015)

Electrical stimulation of myelinated axons: An interactive tutorial supported by computer simulation
Danner SM, Wenger C and Rattay F (eds.)
Saarbrüucken: VDM Verlag (2011).

Transcutaneous electrical spinal cord stimulation: Biophysics of a new rehabilitation method after spinal cord injury.
Száva Z, Danner SM and Minassian K (eds.)
Saarbrücken: VDM Verlag (2011)

Assistant editor, Restorative neurology of spinal cord injury
Dimitrijevic MR, Kakulas BA, McKay WB and Vrbova G (eds.)
New York: Oxford University Press (2011)

Presentations

Invited Lectures

"Human lumbar locomotor networks: neurophysiology and computer modeling"
Danner SM
Departmental seminar, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania (2015)

Mathematical models of the human locomotor network.
Danner SM
APOSM 2014 & ISRN, November 28-30, Taipei, Taiwan (2014)

"Modelling locomotor pattern generating networks of the human lumbar spinal cord"
Danner SM, Rattay F, Hofstoetter US, Mayr W and Minassian K
In Zidar, J. (ed.). International Symposium on Spasticity and Neural Control of Movement with the 30th Dr. Janez Faganel Memorial Lecture, Sept. 4-6, Ljubljana, Slovenia, 30-31, Section for Clinical Neurophysiology of the Slovenian Medical Association (2014)

"Locomotor rhythm and pattern generating networks of the human lumbar spinal cord: Computer modeling study"
Danner SM
Workshop on recent advances in the pathophysiology and neurorehabilitation of spinal lesions, April 13, Trieste, Italy (2013)

Recent Conference Abstracts

"Spinal circuits controlling interlimb coordination and speed-dependent gait expression"
Danner SM, Shevtsova NA and Rybak IA
14th Karniel Computational Motor Control Workshop, March 13–15, Beersheba, Israel (2018)

"Computational modeling study of the role of long propriospinal neurons in speed-dependent gait expression"
Danner SM, Shevtsova NA and Rybak IA
Neuroscience 2017, Nov. 11–15, Washington, D.C. (2017)

"Computational modeling of interactions between cervical and lumbar CPG circuits in the rodent spinal cord in vitro"
Shevtsova NA, Danner SM and Rybak IA
Neuroscience 2017, Nov. 11– 15, Washington, D.C. (2017)

"Spinal circuits controlling speed-dependent gait expression in quadrupeds: insights from computational modeling"
Danner SM, Wilshin SD, Bellardita C, Shevtsova NA, Kiehn O and Rybak IA
Neuroscience 2016, November 12–16, San Diego, California (2016)

"Comparative modeling of spinal mechanisms for speed-dependent gait transitions in quadrupeds"
Danner SM, Shevtsova NA and Rybak IA
Motor Systems Symposium, November 11, San Diego, California (2016)

"The role of commissural interneurons in speed-dependent changes of inter-limb coordination and locomotor gait: insights from computational modeling"
Danner SM, Shevtsova NA and Rybak IA
Pre-meeting on Rhythmic Motor Circuits, Oct. 16, Chicago, Illinois (2015)

"Variation of the stimulation site changes the excitation of the lumbosacral spinal reflexes"
Krenn M, Danner SM, Vargas-Luna JL, Toth A, Hofstoetter US, Minassian K and Mayr W
Progress in Motor Control X, July 22-25, Budapest, Hungary (2015)

"Comparison of cathodic and anodic transspinal electrical stimulation to evoke posterior root-muscle reflexes"
Vargas-Luna JL, Krenn M, Danner SM, Hofstoetter US, Minassian K, Mayr W and Helgason T
Progress in Motor Control X, July 22-25, Budapest, Hungary (2015)

Danner SM, Dimitrijevic MR, Hofstoetter US, Krenn M, Mayr W, Minassian, K., Rattay F and Rothwell, J. C. (2014). Long-latency spinal reflexes predict rhythmicity in response to epidural lumbar cord stimulation. Neuroscience 2014, Nov. 15-19, Washington, D.C.

"Short- and long-term effects of intermittent transcutaneous spinal cord stimulation on spinal spasticity and residual motor control"
Hofstoetter US, Krenn M, Danner SM, Freundl B, Binder H, Rattay F, Mayr W and Minassian K
Neuroscience 2014, Nov. 15-19, Washington, D.C. (2014)

"Altering spinal cord excitability by peripheral nerve stimulation"
Krenn M, Danner SM, Schlaff C, Hofstoetter US, Minassian K, Mayr W and Dimitrijevic MR
Neuroscience 2014, Nov. 15-19, Washington, D.C. (2014)

"Health-related and legal interventions: A comparison of allegedly delinquent and convicted opioid addicts in Austria"
Kochl B, Danner SM, Jagsch R, Brandt L and Fischer G
The 17th EASAR Conference, May 15-17, Luneburg, Germany (2014)

"Motor behavior of the human lumbar spinal cord network responding to externally controlled activity: A neurophysiological study"
Danner SM, Dimitrijevic MR, Hofstoetter US, Krenn M, Mayr W, Minassian K, Rattay F and Rothwell JC
2nd Minnesota Neuromodulation Symposium, April 10-11, Minneapolis, Minnesota (2014)

"Modeling locomotor pattern generating networks of the human lumbar spinal cord"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Epidural stimulation of the human lumbar spinal cord can elicit characteristic tonic motor outputs"
Dimitrijevic MR, Hofstoetter US, Mayr W, Minassian K, Rattay F and Danner SM
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Alternating modulations of posterior root-muscle reflexes of the human lumbosacral spinal cord: Inhibitory circuits outside the lumbar locomotor pattern generator"
Hofstoetter US, Minassian K, Danner SM, Rattay F and Dimitrijevic MR
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Central rhythm and pattern generating capabilities of the human lumbar spinal cord"
Minassian K, Danner SM, Hofstoetter US, Rattay F and Dimitrijevic MR (2013).
Neuroscience 2013, Nov. 9-13, San Diego, California

"Selectivity of transcutaneous lumbar spinal cord stimulation for eliciting posterior root-muscle reflexes in humans"
Krenn M, Toth A, Danner SM, Hofstoetter US, Minassian K and Mayr W
Neuroscience 2013, Nov. 9-13, San Diego, California (2013)

"Segmental and plurisegmental processing capabilities of the human lumbar cord isolated from brain motor control"
Danner SM and Dimitrijevic MR
52nd Annual Scientific Meeting of ISCOS, October 28-30, Istanbul, Turkey (2013)

"Neurophysiology model of the human lumbar cord separated from brain control by traumatic injury"
Danner SM, McKay WB, Minassian K, Hofstoetter US, Mayr W, Rattay F and Dimitrijevic MR
SiNAPSA Neuroscience Conference '13 (SNC'13), September 27-29, Ljubljana, Slovenia (2013)

"Electrophysiology of posterior roots-muscle reflex of the human lumbosacral cord"
Krenn M, Minassian K, Hofstoetter US, Danner SM, Dimitrijevic MR and Mayr W
SiNAPSA Neuroscience Conference '13 (SNC'13), September 27-29, Ljubljana, Slovenia (2013)

"Locomotor rhythm and pattern generating networks of the human lumbar spinal cord: an electrophysiological and computer modeling study"
Danner SM, Rattay F, Hofstoetter US, Dimitrijevic MR and Minassian K
22nd Annual Computational Neuroscience meeting: CNS*2013, July 13-18, Paris, France. BMC Neuroscience, 14 (Suppl 1), P274. DOI: 10.1186/1471-2202-14-S1-P274 (2013)

"Non-invasive spinal cord stimulation and assisted treadmill stepping to generate rhythmic activities in motor complete spinal cord injured people"
Mayr W, Danner SM, Hofstoetter US, Krenn M, Minassian K, Tansey K, Freundl B and Binder H
Wings for Life scientific meeting, April 23-24, Salzburg, Austria (2013)


Contact Information


Research Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8507
Fax: 215.843.9082