• Fellow of the American Heart Association (2022)
• New Investigator Award, Drexel University College of Medicine (2022)
• American Heart Association Scientist Development Grant Award (2017)
• American Heart Association BCVS Cardiovascular Outreach Award (2016)
• American Heart Association BCVS Travel Award (2014)
• Seahorse Bioscience Training Award (2012)
• American Heart Association Postdoctoral Fellowship Award (2012)
• American Heart Association Predoctoral Fellowship Award (2010)
• Upstate New York Cardiac Electrophysiology Society Award, Cornell University (2009)

Visit the Sato Laboratory.

According to the American Heart Association, diabetic patients are two to four times more likely to develop cardiac diseases when compared to non-diabetic patients, and half of deaths in patients with type 2 diabetes are caused by cardiovascular diseases. However, the molecular mechanisms governing cardiac metabolic function and the cross-talk between the heart and other endocrine organs in the human body remain poorly understood.

The Sato Laboratory seeks to understand cardiac physiology and metabolism during metabolic-deteriorating diseases like diabetes. In particular we explore how G-protein coupled receptor (GPCR) signaling pathways mediate metabolic output in the heart and how the pancreas regulates these events beyond insulin/glucagon signaling. Our research approach uses a combination of in vitro biochemical and cellular techniques and in vivo animal models.

Recent Publications

"Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation"
Sato PY, Chuprun JK, Grisanti LA, Woodall MC, Brown BR, Roy R, Traynham CJ, Ibetti J, Lucchese AM, Yuan A, Drosatos K, Tilley DG, Gao E, Koch WJ.
Sci Signal.;11(560). pii: eaau0144. doi: 10.1126/scisignal.aau0144, December 11, 2018

"Monitoring of ovarian cancer cell invasion in real time with frequency-dependent impedance measurement"
Lo C, Lo J, Sato PY, Yeung T, Mok S, Yip K
Am J Physiol Cell Physiol. 1;311(6):C1040-C1047, 2016

"GRK2 Compromises Cardiomyocyte Mitochondrial Function by Diminishing Fatty Acid-Mediated Oxygen Consumption and Increasing Superoxide Levels"
Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod J, Koch WJ
Journal of Molecular and Cellular Cardiology, 2015

"The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease"
Sato PY, Chuprun JK, Schwartz M, Koch WJ
Physiological Reviews, 2015

"Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting"
Chen M*, Sato PY*, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ
Circulation Research, 2013
*Authors contributed equally

Recent Presentations and Posters

“GRK2-S670A mice reveal cardioprotection post ischemia-reperfusion”
Sato PY, Chuprun JK, Woodall MC, Grisanti L, Traynham CJ, Ibetti J, Lucchese A, Yuan A, Tilley D, Gao E, Koch WJ.
Oral and Poster Presentation, International Society of Heart Research, New Orleans, Louisiana, May 30-June 2, 2017

“GRK2-S670A mice reveal cardioprotection post ischemia-reperfusion”
Sato PY, Chuprun JK, Woodall MC, Grisanti L, Traynham CJ, Ibetti J, Lucchese A, Yuan A, Tilley D, Gao E, Koch WJ.
Oral and Poster Presentation, 6th Regional Translational Research in Mitochondrial, Aging, and Disease (TriMAD) Symposium at the Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, October 28-29, 2016

“GRK2-S670A mice reveal cardioprotection after ischemia-reperfusion”
Sato PY, Chuprun JK, Traynham CJ, Lucchese, A, Yuan A, Gao E, Koch WJ.
Poster, Basic Cardiovascular Sciences (BCVS) Scientific Sessions. Phoenix, Arizona, July 18-21, 2016

“GRK2 Compromises Cardiomyocyte Mitochondrial Function by Diminishing Fatty Acid-Mediated Oxygen Consumption and Increasing Superoxide Levels”
Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod J, Koch WJ
Oral Presentation, Temple University Medical School, CRVC and CTM Trainee Seminar Series, Philadelphia, Pennsylvania, September 24, 2015

"Mitochondrial-targeted GRK2 increases superoxide formation and impairs cardiomyocyte respiratory reserve capacity"
Sato PY, Chuprun JK, Ibetti J, Elrod JW, Koch WJ
Poster, Temple University Medical School CRVC and CTM Day, Philadelphia, Pennsylvania, June 17, 2015
Poster, Basic Cardiovascular Sciences (BCVS) Scientific Sessions. Las Vegas, Nevada, July 15, 2014