“Field-based potency optimization of a novel azabicyclo-hexane scaffold HIV-1 entry inhibitor”
Meuser ME, Rashad AA, Ozorowski G, Dick A, Ward AB, and Cocklin S
Molecules, Under revision, 2019
"Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency"
Meuser ME, Murphy MB, Rashad AA, and Cocklin S
Molecules, 23(8), 1940, 2018
"Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action"
Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, and Cocklin S
Journal of Drug Design and Research, 5(2):1070, 2018
"Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library"
Wu G, Zalloum WA, Meuser ME, Jing L, Kang D, Chen CH, Tian Y, Zhang F, Cocklin S,* Lee KH,* Liu X,* and Zhan P*
European Journal of Medicinal Chemistry, 5;158:478-492, 2018
*Corresponding authors
"Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding"
Rao MV, Williams DR, Cocklin S, and Loll PJ
Journal of Biological Chemistry, 292(45):18392-18407, 2017
"The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding"
Rajiv C, Jackson SR, Cocklin S, Eisenmesser EZ, Davis TL
Biochemical Journal, 474(21):3689-3704, 2017
"IgG Binding Characteristics of Rhesus Macaque FcγR"
Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles AR, Eckman GW, Alter G, Schmitz JE, and Ackerman ME
Journal of Immunology, 197(7):2936-47, 2016
"Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis"
Williams PA, Krug MS, McMillan EA, Peake JD, Davis TL, Cocklin S, and Strochlic TI
Molecular Biology of the Cell, 27(15):2341-50, 2016
"Insertion of perilipin 3 into glycero(phosphor-)lipid monolayer depend on lipid headgroup and acylchain species"
Mirheydari M, Rathnayake SS, Frederick H, Arhar T, Mann EK, Cocklin S, and Kooijman EE
Journal of Lipid Research, 57(8):1465-76, 2016
"Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors"
Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, and Mazin AV
Nucleic Acid Research, 44(9):4189-99, May 19, 2016
"Identification of a small molecule HIV-1 inhibitor that targets the hexameric capsid"
Xu JP, Branson JD, Lawrence R, and Cocklin S
Bioorganic and Medicinal Chemistry Letters, 26(3):824-8, Feb 1, 2016
"Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement"
Tuyishime M, Lawrence R, and Cocklin S
Bioorganic and Medicinal Chemistry Letters, 26(1):228-34, Jan 1, 2016
"Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacements"
Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, and Cocklin S
Bioorganic and Medicinal Chemistry Letters, 24(23):5439-5445, Oct 16, 2014
"Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication"
Kortagere S,* Xu JP, Mankowski M, Ptak RG, and Cocklin S*
Journal of Chemical Information and Modeling, 54(11):3080-90, Nov 24, 2014
*Corresponding authors
"An Optimized, Synthetic DNA Vaccine Encoding the Toxin A and Toxin B Receptor Binding Domains of Clostridium difficile Induces Protective Antibody Responses In Vivo"
Baliban SM, Michael A, Shammassian B, Mudakha S, Khan AS, Cocklin S, Zentner I, Latimer BP, Bouillaut L, Hunter M, Marx P, Sardesai NY, Welles SL, Jacobson JM, Weiner DB, and MA Kutzler
Infection and Immunity, 82(10):4080-91, 2014
"The high resolution structure of tyrocidine A reveals an amphipathic dimer"
Loll PJ, EC Upton, V Nahoum, NJ Economou, and S Cocklin
Biochimica et Biophysica Acta, 1838:1199-1207, 2014
"Identification of a Small-Molecule Inhibitor of HIV-1 Assembly that Targets the Phosphatidylinositol (4,5)-bisphosphate Binding Site of the HIV-1 Matrix Protein"
Zentner I, Sierra LJ, Fraser AK, Maciunas L, Mankowski MK, Vinnik A, Fedichev P, Ptak RG, Martin-Garcia J, and Cocklin S
ChemMedChem 8:426-432, 2013
"Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation"
Checkley MA, Luttge BG, Mercredi PY, Kyere SK, Donlan J, Murakami T, Summers MF, Cocklin S, and EO Freed
J Virol 87:3561-3570, 2013
"Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein"
Zentner I, Sierra LJ, Maciunas L, Vinnik A, Fedichev P, Mankowski MK, Ptak RG, Martin-Garcia J, and Cocklin S
Bioorganic & Medicinal Chemistry Letters 23:1132-1135, 2013
"Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid"
Kortagere S, Madani N, Mankowski MK, Schon A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martin-Garcia J, Freire E, Ptak RG, Sodroski J, Cocklin S, and Smith AB, 3rd.
Journal of Virology 86:8472-8481, 2012
"Solution structure studies of monomeric human TIP47/perilipin-3 reveal a highly extended conformation"
Hynson RM, Jeffries CM, Trewhella J, and Cocklin S
Proteins 80:2046-2055, 2012
"Inhibition of homologous recombination in human cells by targeting RAD51 recombinase"
Huang F, Mazin OM, Zentner IJ, Cocklin S and Mazin AV
Journal of Medicinal Chemistry 55:3011-3020, 2012
"A carrier protein strategy yields the structure of dalbavancin"
Economou NJ, Nahoum V, Weeks SD, Grasty KC, Zentner IJ, Townsend TM, Bhuiya MW, Cocklin S, and Loll PJ
Journal of the American Chemical Society 134:4637-4645, 2012
"Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18"
Gift SK, Zentner IJ, Schon A, McFadden K, Umashankara M, Rajagopal S, Contarino M, Duffy C, Courter JR, Zhang MY, Gershoni JM, Cocklin S, Dimitrov DS, Smith AB 3rd, Freire E, and Chaiken IM
Biochemistry;50(14):2756-2768, 2011
"Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120"
Gopi H, Cocklin S, Pirrone V, McFadden K, Tuzer F, Zentner I, Ajith S, Baxter S, Jawanda N, Krebs FC, and Chaiken IM
Journal of Molecular Recognition. 22(2):169-174, 2009
"The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and reduced sensitivity to entry inhibitors"
Rossi F, Querido B, Nimmagadda M, Cocklin S, Navas-Martín S, and Martín-Garcia J
Retrovirology Oct 6; 5:89, 2008
"Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425"
Kamat K, Donaldson JM, Kari C, Quadros MRD, Lelkes P, Chaiken I, Cocklin S, Williams JC, Papazoglou E, and Rodeck U
Cancer Biology & Therapeutics. 7(5):726-733, 2008
"Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1 Envelope gp120"
Gopi, HN, Umashankara M, Pirrone,V., LaLonde, J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller, SR., Schön A, Klein JC., Freire E, Krebs, FC, Smith III, A.B., Sodroski, J, and Chaiken, I.
Journal of Medicinal Chemistry.51(9):2638-2647, 2008
"A recombinant allosteric lectin antagonist of HIV-1 Envelope gp120 interactions"
McFadden K, Cocklin S, Gopi HN, Baxter S, Ajith S, Mahmood N, Shattock R, Chaiken IM
Proteins: Structure, Function and Bioinformatics. 67(3):617-629, 2007
"Broad-spectrum anti-HIV potential of a peptide HIV-1 entry inhibitor"
Cocklin S*, Gopi HN, Querido B, Nimmagadda M, Kuriakose S, Cicala C, Ajith S, Baxter S, Arthos J, Martin-Garcia J, and Chaiken I (*corresponding author)
Journal of Virology. 81(7):3645-3648, 2007
"Antibody binding in proximity to retroviral envelope glycoproteins leads to a basal level of neutralization"
Yang X, Lipchina I, Cocklin S, Chaiken IM, and Sodroski J
Journal of Virology. 80(22):11404-1108, 2006
"Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis"
Cocklin S, Jost M, Robertson NM, Weeks SD, Weber H-W, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest R, and Chaiken IM
Journal of Molecular Recognition. 19(4):354-362, 2006
"Interaction with CD4 and antibodies to CD4-induced epitopes of monomeric gp120 from a microglia-adapted human immunodeficiency virus type 1 isolate"
Martín-García J, Cocklin S, Chaiken IM, and González-Scarano F
Journal of Virology. 79(11):6703-6713 (2005)
"Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis"
Lamb HK, Ren J, Park A, Johnson C, Leslie K, Cocklin S, Thompson P, Mee C, Cooper A, Stammers DK, and Hawkins AR
Protein Science. 13(12):3127-3138 (2004)
"Small molecule inhibitors of the HIV-1 envelope block receptor-induced conformational changes in the viral envelope glycoproteins"
Si Z, Madani N, Cox JM, Chruma JJ, Klein JC, Schon A, Phan N, Wang L, Biorn AC, Cocklin S, Chaiken I, Freire E, Smith AB, and Sodroski JG
Proceedings of the National Academy of Sciences USA. 101(14):5036-5041, 2004
"Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions"
Biorn AC*, Cocklin S*, Madani N*, Si Z, Ivanovic T, Samanen J, Van Ryk DI, Pantophlet R, Burton DR, Freire E, Sodroski J, and Chaiken I
Biochemistry. 43(7):1928-1938, 2004
*Equal authorship
"Proteins, recognition networks and developing interfaces for macromolecular biosensing"
Sergi M, Zurawski J, Cocklin S, and Chaiken I
Journal of Molecular Recognition. 17(3):198-208, 2004
"The PDZ domains of the HtrA protease/chaperonin and the Tsp protease facilitate substrate binding"
Spiers A, Lamb HK, Cocklin S, Wheeler KA Budworth J, Dodds AL, Pallen MJ, Maskell DJ, Charles IG, and Hawkins AR
Journal of Biological Chemistry. 277(42):39443-39449, 2002
"The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases"
Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, and Hawkins AR
EMBO Journal. 20(23):6619-6626, 2001
"Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression"
Nichols CE, Cocklin S, Dodds A, Ren J, Lamb H, Hawkins AR, and Stammers DK
Acta Crystallographica D Biological Crystallography. 57(11):1722-1725, 2001