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Michael Lane

Michael Lane, PhD

Associate Professor

Department: Neurobiology & Anatomy


  • PhD in Pharmacology - University of Melbourne, Australia (2004)
  • BSc in Anatomy and Physiology (summa cum laude) - University of Tasmania, Australia (1999)

Awards & Honors

  • Mentor Award, Drexel Graduate School of Biomedical Science and Professional Studies, 2017
  • Elected fellow, American Society for Neural Therapy & Repair, 2015
  • Young Faculty Award, American Association of Anatomists, 2010
  • Postdoctoral Travel Award, American Association of Anatomists, 2009
  • Postdoctoral Award, Society for Neuroscience, 2008
  • Presentation Award, Neuromuscular Plasticity Symposium, 2008

Memberships / Professional Affiliations

  • Australian Neuroscience Society (ANS)
  • Society for Neuroscience (SfN)
  • International Neurotrauma Society
  • American Association of Anatomists
  • American Society for Neural Therapy and Repair (ASNTR)

Michael Lane, PhD, is an associate professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. He leads a research team consisting of two graduate students and one junior faculty member (instructor).

Prior to coming to Drexel, Dr. Lane was an assistant professor in the Department of Neuroscience at the University of Florida, McKnight Brain Institute. He also served as a lecturer in the annual NIH-funded Spinal Cord Injury Training Program at The Ohio State University from 2009 to 2013.

Research Overview

Research Interests

Spontaneous and therapeutically enhanced neural plasticity following cervical spinal cord injury


After completing his graduate studies and early postdoctoral work in spinal cord injury (SCI) in Australia at the University of Melbourne, Dr. Lane relocated to the University of Florida to investigate the neuroplastic potential of the injured cervical spinal cord. This research developed a particular focus on respiratory dysfunction and spontaneous recovery. In 2013, Dr. Lane moved to the Spinal Cord Research Center within Drexel University College of Medicine's Department of Neurobiology & Anatomy to continue his research into neuroplasticity following cervical SCI. Employing a range of electrophysiological, behavioral and neuroanatomical methods, the present goal of his research team is to 1) better define the extent of functional and anatomical plasticity at spinal and supraspinal levels and 2) develop and test therapeutic strategies to enhance spontaneous neuroplasticity and lasting functional recovery. Among those therapeutic approaches being tested are intraspinal cell transplantation and rehabilitative strategies.

Current Funding

Title: "Neural transplants to promote respiratory plasticity after spinal cord injury"
Agency: National Institutes of Health, NINDS (R01 NS104291)
Project dates: 2018-2022
Role on project: Principal Investigator

Title: "Stem cell–derived spinal interneurons to repair the injured spinal cord"
Agency: The Lisa Dean Moseley Foundation
Project dates: 2017
Role on project: Principal Investigator

In the Media


Recent Publications

"Transplanting neural progenitors to repair the injured spinal cord"
Spruance VM, Zholudeva LV, Plant G, Reier PJ, Fischer I, Lane MA
Accepted by Progress in Neurobiology (invited, 2018)

"Daily acute intermittent hypercapnia training enhances anatomical plasticity after cervical spinal cord injury"
Randelman M, Zholudeva LV, Spruance VM, Hormigo KM, Bezdudnaya T, Marchenko V, Lane MA
Accepted by Nature Neuroscience (2018)

"The neuroplastic and therapeutic potential of interneurons in the injured spinal cord"
Zholudeva LV, Qiang L, Marchenko V, Dougherty KJ, Sakiyama-Elbert SE, Lane MA
Trends in Neuroscience (invited), 41(9): 625-639 [PMID: 30017476] (2018)

"Transplantation of neural progenitors and V2a interneurons after spinal cord injury"
Zholudeva LV, Iyer N, Qiang L, Spruance VM, Randelman ML, Bezdudnaya TG, Fischer I, Sakiyama-Elbert S, Lane MA
J Neurotrauma - Online [PMID: 29873284] (2018)

"Paced breathing and phrenic nerve responses evoked by epidural stimulation following complete high cervical spinal cord injury"
Bezdudnaya T, Lane MA, Marchenko V
J Applied Physiology, 125(3): 687-696 [PMID: 29771608] (2018)

"Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats"
Bezdudnaya T, Hormigo TM, Marchenko V, Lane MA
Experimental Neurology, 305: 56-65 [PMID: 29596845] (2018)

"Integration of transplanted neural precursors with the injured spinal cord"
Spruance VM, Zholudeva LV, Hormigo KM, Bezdudnaya T, Marchenko V, Lane MA
J Neurotrauma, 35(15): 1781-1799 [PMID: 29295654] (2018)

"Anatomical recruitment of spinal V2a interneurons into phrenic motor circuitry after high cervical spinal cord injury"
Zholudeva LV, Karliner J, Dougherty K, Lane MA
J Neurotrauma, 34(21):3058-3065 [PMID: 28548606] (2017)

"Supraspinal respiratory plasticity following acute cervical SCI"
Bezdudnaya TG, Marchenko V, Zholudeva LV, Spruance VM, Lane MA
Experimental Neurology, 293: 181-189 [PMID: 28433644] (2017)

"Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury"
Lane MA, Lepore AJ, Fischer I
Expert Review of Neurotherapeutics, 21: 1-8 [PMID: 27917734] (2017)

"Histological identification of phrenic afferent projections to the spinal cord"
Nair J, Bezdudnaya T, Zholudeva LV, Detloff M, Reier PJ, Lane MA*, Fuller DD
Respiratory Physiology & Neurobiology, 236:57-68 [PMID: 27838334] (2017)
(*Co-corresponding author)

"Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury"
Hormigo KM, Zholudeva LV, Spruance VM, Marchenko V, Pascale M-P, Vinit S, Giszter S, Bezdudnaya T, Lane MA
Experimental Neurology, 287(Pt2):276-287[PMID: 27582085] (2017)

"Forelimb muscle plasticity following unilateral cervical spinal cord injury"
Gonzalez-Rothi EJ, Armstrong GT, Cerreta AJ, Fitzpatrick GM, Reier PJ, Lane MA, Judge AR, Fuller DD
Muscle Nerve, 53(3): 475-478 (2016)

"Spinal Interneurons and forelimb neuroplasticity following incomplete, high cervical spinal cord injury in adult rats"
Gonzalez-Rothi EJ, Rombola AM, Rousseau CA, Mercier LM, Fitzpatrick GM, Reier PJ, Fuller DD, Lane MA 
Journal of Neurotrauma, 32(12): 893-907 (2015)

"Diaphragmatic motor response evoked by transcranial magnetic stimulation in the rat"
Vinit S, Keomani E, Deramaudt T, Spruance VM, Bezdudnaya TG, Lane MA, Bonay M, Petitjean M
PLOS One, 9(11):e113251(2014)

"Intraspinal transplantation and modulation of donor neuron electrophysiological activity"
Lee K-Z, Lane MA, Dougherty BJ, Mercier LM, Sandhu MS, Sanchez JC, Reier PJ, Fuller DD
Experimental Neurology, 251C: 47-57 (2013)

"Phrenic motoneuron discharge patterns following chronic cervical spinal cord injury"
Lee K-Z, Dougherty BJ, Sandhu MS, Lane MA, Reier PJ, Fuller DD
Experimental Neurology, 249: 20-32 (2013)

"Respiration following spinal cord injury: evidence for human neuroplasticity"
Hoh DJ, Mercier LM, Hussey S, Lane MA
Respiratory Physiology and Neurobiology, 189(2): 450-464 - Invited Review (2013)

"Recovery of inspiratory intercostal muscle activity following high cervical hemisection"
Dougherty BJ, Lee KZ, Gonzalez-Rothi EJ, Lane MA, Reier PJ, Fuller DD
Respiratory Physiology and Neurobiology, 183(3): 186-192 (2012)

"Retrograde gene delivery to hypoglossal motoneurons using AAV9"
ElMallah MK, Falk DJ, Lane MA, Lee KZ, Shafi NI, Reier PJ, Byrne BJ, Fuller DD
Human Gene Therapy Methods, 23(2): 148-156 (2012)

"Respiratory function following bilateral mid-cervical contusion injury in the adult rat"
Lane MA, Lee KZ, Salazar K, O'Steen BE, Fuller DD, Reier PJ
Experimental Neurology, 235(1): 197-210 - Special Issue on Spinal Cord Plasticity (2012)
Invited Original Research Publication

Book Chapters - Peer Reviewed

"Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications"
Zholudeva LV, Jin Y, Qiang L, Lane MA, Fischer I
In: Methods in Molecular Biology – Neuronal Culture. Humana Press (2018)

"Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems"
Reier PJ, Zholudeva LV, Lane MA
In: Conn PM (Ed). Conn's Translational Neuroscience. Elsevier Inc. Chapter 25 (2016)

"Spinal Cord: Repair and Rehabilitation"
Reier PJ, Hoh DJ, Mitchell G, Behrman AL, Howland DR and Lane MA
In: Encyclopedia of Life Sciences, John Wiley & Sons, U.K. (2016)

"Translational spinal cord injury research: Preclinical guidelines and challenges"
Reier PJ, Lane MA, Hall ED, Teng YD, Howland DR
In: Handbook of Clinical Neurology, Verhaagen J, McDonald JW (Eds). Amsterdam, Elsevier. 109: pp. 411-433 (2012)

Contact Information

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8892
Fax: 215.843.9082