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Mark Zarella

Mark Zarella, PhD

Research Assistant Professor; Technical Director, Advanced Pathology Imaging Lab

Department: Pathology & Laboratory Medicine


  • BS in Physics - University of Massachusetts
  • PhD in Neuroscience - SUNY Upstate Medical University
  • Postdoctoral Fellowship in Neurobiology - University of Rochester

Memberships / Professional Affiliations

  • Education Committee, Digital Pathology Association
  • Website Committee, Digital Pathology Association
  • Member, SPIE
  • Member, Association for Pathology Informatics
  • Member, Digital Pathology Association

Mark Zarella, PhD, is a research assistant professor in the Department of Pathology and Laboratory Medicine at Drexel University College of Medicine.

Research Interests

Breast cancer diagnostics, pathology imaging, bioinformatics, computer vision, digital pathology.


Dr. Zarella incorporates concepts in digital imaging, signal processing and bioinformatics toward the goal of understanding biological systems.

Learn More at the Zarella Lab

In the Media


See Dr. Zarella's Orcid publication list

"A Practical Guide to Whole Slide Imaging: A White Paper From the Digital Pathology Association"
Mark D. Zarella, Douglas Bowman, Famke Aeffner, Navid Farahani, Albert Xthona, Syeda Fatima Absar, Anil Parwani, Marilyn Bui and Douglas J. Hartman
Archives of Pathology & Laboratory Medicine (October 11, 2018)

"Laboratory computer performance in a digital pathology environment: outcomes from a single institution"
Zarella MD, Feldscher A
J Pathol Inform 9(1):44-49 (2018)

"Estimation of Fine-Scale Histologic Features at Low Magnification"
Mark D. Zarella, Matthew R. Quaschnick, David E. Breen and Fernando U. Garcia
Archives of Pathology & Laboratory Medicine (June 18, 2018)

"Image processing to extend effective OCT penetration depth in tissue"
Nandakumar G, Maharaj S, Breen DE, Garcia FU, Zarella MD
Proc SPIE Med Imag 10581: Digital Pathology (2018)

"An alternative image representation for the reduced impact of H&E staining variability"
Zarella MD, Yeoh C, Breen DE, Garcia FU
PLoS One. 12(3): e0174489 (2017)

"A template matching model for nuclear segmentation in digital images of H&E stained slides"
Zarella MD, Breen DE, Xin W, Garcia FU
Proceedings of the 9th International Conference on Bioinformatics and Biomedical Technology, Lisbon, Portugal (2017)

"Contextual modulation revealed by optical imaging exhibits figural asymmetry in macaque V1 and V2"
Zarella MD, Ts’o DY
Eye and Brain (9): 1-12 (2017)

"Cue combination encoding via contextual modulation of V1 and V2 neurons"
Zarella MD, Ts’o DY
Eye and Brain (8): 177-193 (2016)

"Lymph node metastasis status in breast carcinoma can be predicted via image analysis of tumor histology"
Zarella MD, Breen DE, Reza MdA, Milutinovic A, Garcia FU
Anal. Quant. Cytol. Histol. 37(5): 273-285 (2015)

"An optimized color transformation for the analysis of digital images of Hematoxylin and Eosin stained slides"
Zarella MD, Breen DE, Plagov A, Garcia FU
J Pathol Inform 6(1): 33-41 (2015)

"Painful Unilateral Temporalis Muscle Enlargement: Reactive Masticatory Muscle Hypertrophy"
Katsetos CD, Bianchi MA, Jaffery F, Koutzaki S, Zarella MD, Slater R
Head Neck Pathol. 8(2): 187-193 (2013)

"Whither the hypercolumn?"
Ts'o DY, Zarella MD, Burkitt G
J. Physiol. 587, 2791-2805 (2009)

Contact Information

Research Office

Department of Pathology & Laboratory Medicine
245 N. 15th Street
MS 435
Philadelphia, PA 19102
Phone: 215.762.8657
Fax: 215.762.3274