Analgesia Drug Discovery
The Ajit Lab is interested in pursuing various aspects of epigenetics including DNA methylation, histone modifications, and RNA-mediated gene silencing, all aimed at understanding the molecular mechanisms underlying pain.
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Oncology Drug Discovery
Ongoing projects in the Fatatis Lab aim to understand the molecular and functional interactions underpinning the metastatic process, and identify molecular targets for effective therapies to counteract the dissemination and growth of cancer cells.
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CNS Drug Discovery
Current projects in the A. Mortensen Lab include the identification and development of allosteric compounds that enhance the activity of EAAT2 (the main glutamate transporter in the brain) and the examination of potential neuroprotection of these compounds in in vitro and in vivo models. In addition, our lab is interested in mechanisms involved in transport augmentation that could lead to therapies to treat disorders in which excitotoxicity is involved.
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The overarching goal of research at the Ole Mortensen Lab is to develop a clear understanding of the molecules and pathways involved in the pathoetiology of brain disorders and to use this information to develop new therapeutic targets. More specifically, we are focusing our research on the monoamine neurotransmitters dopamine, serotonin, and norepinephrine that all play a central role in modulating most brain activity. We are interested in understanding the regulation of monoaminergic neurotransmission at all levels from the molecular level where we study monoaminergic proteins to the systems level where we study behaviors modulated by monoamines.
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