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Center for Cellular & Molecular Neuroscience

The Center for Cellular and Molecular Neuroscience is based in the Department of Neurobiology & Anatomy, and also includes members from across departments and colleges at Drexel University (and other institutes in Philadelphia), with the shared mission of elucidating the cellular and molecular mechanisms underlying the development and functioning of the nervous system as well as diseases, disorders and injuries of the nervous system.

Representative whole mount immunostaining images of assembloids with phenotypes and morphologies relevant to the study of frontotemporal demnetia. Source: Liang Qiang Lab.
Representative whole mount immunostaining images of assembloids with phenotypes and morphologies relevant to the study of frontotemporal demnetia. Source: Liang Qiang Lab.

RESEARCH AREAS

  • Neuronal cytoskeleton
  • Microtubule and actin regulation
  • Molecular motor proteins
  • Hereditary spastic paraplegia
  • Human induced pluripotent cell derived in vitro and ex vivo models
  • Gulf War Illness
  • Tau and tauopathies
  • Protein degradation and autophagy
  • Neuronal migration
  • Neurite outgrowth
  • Neuronal polarity
  • Axonal and dendritic development
  • Autism spectrum disorders
  • Spinal cord injury
  • Traumatic brain injury
  • Axonal transport
  • Extracellular signaling
  • Spine and synapse formation
  • Miller-Dieker and 17p13.3 duplication syndrome
  • Neurodevelopmental disorders
  • Astrocyte diversity, development and modulation of synapses

Experimental model systems

  • Primary cultures of rat and mouse neurons
  • Mouse models for diseases of the nervous system and other transgenic mouse lines
  • Human induced pluripotent cell derived neurons and cerebral organoids
  • Neuronal cell lines
Growth cone from a 3-day old rat hippocampal neuron in culture, expressing fluorescent actin (in purple) and fluorescent microtubule end-binding protein EB3 (in blue).

 

Figure Legend: Growth cone from a 3-day old rat hippocampal neuron in culture, expressing fluorescent actin (in purple) and fluorescent microtubule end-binding protein EB3 (in blue). The EB3 appears as comets traversing through the growth cone. (Shrobona Guha and Peter Baas)

Experimental approaches

  • Live-cell imaging, including calcium imaging
  • Immunocytochemistry and immunohistochemistry
  • Standard molecular biological approaches including Western Blotting, RT-PCR, site-directed mutagenesis, etc.
  • Single-cell RNA sequencing
  • Proteomics
  • Behavioral analyses on mice and rats
  • Mouse molecular genetics and lineage tracing
  • Super resolution microscopy
  • In utero electroporation
  • RNAi based knockdown and cDNA-based gene overexpression
  • In vivo neuronal connectivity
  • Chemogenetics and optogenetics

MEET OUR FACULTY

You can learn more about our research and current projects by visiting our individual faculty lab pages.

MEET OUR STUDENTS

Baas Lab
Shrobona Guha
Kendra Case
Julie Schaub
Bridie Eckel

Toyo-oka Lab
Xiaonan (Nan) Liu
Anurag Singh

Garcia Lab
Anh Duc (Mike) Le
Kathryn Markey

Raghupathi Lab
Taylor McCorkle
Zoe Romm

Ma Lab
Bridget Curran
Elizabeth Moese
Althea Escorce

Qiang Lab
Xiaohuan (Beanie) Sun
Neha Mohan
Simeon Kofman
Skandha Ramakrishnan

Spiliotis Lab
Megan Radler
Yani Suber
Ben Robinson
Noor Alam

Tom Lab
Micaela O’Reilly
Ashraful Islam
Mariah Wulf

Meet Our Senior Personnel

Wenqian Yu
Senior Scientist and Lab Manager, Baas Lab

Ying Jin
Senior Scientist, Fischer Lab

Emanuela Piermarini
Senior Scientist, Baas and Qiang Lab

Koray Kirimtay
Postdoc, Baas Lab

Stephen Tymanskyj
Instructor, Ma Lab

Priyanka Bhakt
Postdoc, Spiliotis Lab

 
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