Pearlstein Gallery is pleased to present two concurrent exhibitions in Spring 2026, with artists selected from our 2025-26 Call for Entries.  

Conflagrations, a group show featuring recent works by Viola Bordon, Evan Curtis Charles Hall, Narendra Haynes, and Emmanuela Soria Ruiz, investigates fire as force, event, and aftermath.  Moving between active burn and residual trace, the artists ask how we might respond to fire's capacity to clear, consume, reveal, and reorder. As fire increasingly shapes our ecological context, these works reflect on how fire constructs and destroys in the same gesture, reshaping ecologies, infrastructures, and collective memory. What burns. What survives. What returns.  


Gallery Hours:
Tuesday - Friday 12 p.m. - 6 p.m.
Saturday 12 p.m. - 5 p.m.


About Pearlstein Gallery: 

The Leonard Pearlstein Gallery is an inclusive gallery space that welcomes the public to experience free exhibitions of contemporary art and design. Located on Drexel University’s campus, the Pearlstein Gallery is committed to cultivating engagement with emerging artists, Drexel’s faculty and student populations, and community partners in the nearby neighborhoods of Powelton Village and Mantua. Since its creation in 2012, the Gallery has fostered innovation and collaboration, developing strong relationships within Philadelphia’s arts and culture sector.  

BIOMED PhD Thesis Defense

Title: 
Transcriptomic Analysis of Circadian Rhythm Disruption and Intercellular Desynchrony in the Human Brain with Alzheimer's Disease

Speaker:
Henry Hollis, PhD Candidate
School of Biomedical Engineering, Science and Health Systems
Drexel University

Advisors:
Ron Anafi, MD, PhD
Associate Professor
Perelman School of Medicine
University of Pennsylvania

Andres Kriete, PhD
Associate Dean for Academic Affairs and Teaching Professor
School of Biomedical Engineering, Science and Health Systems
Drexel University 

Details:
Disrupted behavioral circadian rhythms are a hallmark of Alzheimer’s disease (AD), but transcriptional rhythms in AD subjects have not been well studied. To address this, we informatically ordered post-mortem human brains with and without AD to reconstruct molecular rhythms in control (CTL) and AD samples. We found that while core clock rhythms remained largely intact, critical metabolic output pathways, specifically ribosome and oxidative phosphorylation, were severely dampened. 

Our experimental validation in mice mirrored these transcriptomic findings. A fundamental ambiguity in circadian biology is whether this type of tissue-level dampening stems from a loss of individual cellular amplitude or an increase in intercellular phase dispersion (cells drifting out of sync). To resolve this, we developed a novel computational framework: ORPHEUS. Applying this tool revealed that phase dispersion, rather than strictly weakened individual cellular rhythms, drives the dampened metabolic rhythms observed in AD. Ultimately, this work provides a detailed understanding of circadian disruption in neurodegeneration and introduces a powerful computational tool for analyzing complex tissue rhythms.

CLASS Study Hours   offered  Drop in to chat with an academic coach or get some work done with a little extra accountability!  

Join other multilingual writers for weekly writing sessions.

Pennoni will be visiting Drexel University’s campus to host an information session focused on civil engineering and the firm’s work in Philadelphia. This event will provide insight into Pennoni’s projects, company culture, and opportunities for students interested in civil engineering.

Join us for another edition of the UHC's Invited Speaker Series with Rebekah Israel Cross, Assistant Professor of Public Health Sciences at The University of Chicago!