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All Graduate Student Events at Drexel

  • Virtual BIPOC Drop-ins

    Tuesday, December 6, 2022

    1:00 PM-3:00 PM

    Center for Black Culture Rush Building Rm 132

    • Undergraduate Students
    • Graduate Students

    15-20 minute check-ins with out BIPOC Mental Health Specialist, Robia Smith-Herman via Zoom! Talk about whatever is important to you

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  • Bryn Mawr College Master of Social Service Information Session

    Tuesday, December 6, 2022

    6:30 PM-8:00 PM

    Virtual - Register on Handshake

    • Undergraduate Students
    • Graduate Students
    • Senior Class

    Interested in a secondary degree social work? Learn about Bryn Mawr’s programs at this information session. And if you have questions about pursuing a master’s degree, feel free to reach out to Graduate & Pre-professional Advisor, Melissa Bennett, at mab836@drexel.edu for a one-on-one appointment.

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  • Alternative Lengthening of Telomeres in Cancer

    Wednesday, December 7, 2022

    10:00 AM-12:00 PM

    Remote

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff

    BIOMED PhD Research Proposal

    Title:
    Alternative Lengthening of Telomeres in Cancer

    Speaker:
    Kaitlin Raseley, PhD Candidate
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Advisor:
    Ming Xiao, PhD
    Professor
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Details:
    In humans, telomeres are nucleoprotein complexes made up of tandem 5′TTAGGG3′ DNA repeats and associated proteins located at the ends of all 46 chromosomes. Telomere (TTAGGG)n tract loss beyond a certain threshold changes the telomere structure (“uncapping”), which causes telomere dysfunction and leads to senescence or apoptosis.  

    The cancer cells utilize one of the two Telomere Maintenance Mechanisms (TMM) to maintain their telomeres during uncontrolled proliferation,  telomerase, and alternative lengthening of telomeres (ALT).  ALT is commonly thought to occur in about 10–20% of all tumors and relies on many DNA damage response (DDR) proteins, including those involved in the homology-dependent repair (HDR) pathway.

    Here we use a Single Molecule Telomere Assay Optical Mapping (SMTA-OM) assay, capable of quantifying individual telomeres from single molecules across all chromosomes to analyze the telomeric features in ALT+ cancer cells. ALT+ cells display some unique features including increased fusions/internal telomere-like sequence (ITS+), fusions/internal telomere-like sequence loss (ITS-), telomere-free ends (TFE), superlong telomeres, and telomere length heterogeneity, compared to Telomerase+ (TEL+) cancer cells. The readouts may be used as biomarkers for ALT+ cancer cells. The differences seen in the SMTA-OM assay results between ALT+ cancer cells could also be used to subtype the ALT+ cancers and monitor cancer therapy.

    We applied the SMTA-OM for understanding the mechanism of ALT pathways. Our results show targeting telomeric sequence with a catalytically inactive Cas9 (dCas9) physically prevents DNA replication machinery progression. Blocking replication machinery led to an increase in DNA damage and an increase in unique structural changes in the telomere and adjacent subtelomere, likely resulting from the upregulation of the ALT pathways.  

    We also plan to combine the high-resolution SMTA-OM with a newly developed sequencing protocol, potentially identifying the chromosomal origins of the newly fused portion in the fusion DNA molecules. It is currently unknown whether the molecular fusions are occurring between the same chromosome arm(s) or whether interactions between chromosomes are completely random during the breakage-fusion-bridge (BFB) cycle after activation of the ALT pathway. It is essential to continue investigating the behavior of the ALT pathway in ALT+ cancer cells, especially at the single-molecule level, and these proposed methods make it possible. Despite recent advances in this area of research, there are still critical unanswered questions.

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  • December QuIEHR Working Group Journal Club

    Wednesday, December 7, 2022

    11:00 AM-12:00 PM

    Online

    • Undergraduate Students
    • Graduate Students
    • International Students
    • LGBTQA Community
    • Faculty
    • Staff

    Join the Queer Inclusion, Equity, Health, and Rights (QuIEHR) Working Group for our December journal club meeting.

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  • Virtual: Pediatrics Grand Rounds

    Wednesday, December 7, 2022

    12:00 PM-1:00 PM

    Online Event: Please contact organizer for zoom link

    • Graduate Students
    • Faculty
    • Staff
    • Medical Residents/Fellows

    Topic
    Positive Childhood Experiences: A Paradigm Shift in Pediatric Care

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  • Microbiology & Immunology Seminar

    Wednesday, December 7, 2022

    1:00 PM-2:00 PM

    New College Building, Geary A

    • Graduate Students
    • Faculty
    • Staff

    Topic
    Astrocytic HIV-1 Nef – A Potent Neurotoxin That Goes the Extra Mile on the Brain-Body Highway

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  • In-person BIPOC Drop-ins

    Wednesday, December 7, 2022

    2:00 PM-4:00 PM

    Center for Black Culture Rush Building Room 132

    • Undergraduate Students
    • Graduate Students

    15-20 minute check-ins with out BIPOC Mental Health Specialist, Robia Smith-Herman! Talk about whatever is important to you

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  • Pathogenicity Classification of Somatic Mutations in Precision Medicine

    Wednesday, December 7, 2022

    3:00 PM-5:00 PM

    Bossone Research Center, Room 709, located at 32nd and Market Streets. Also on Zoom.

    • Undergraduate Students
    • Graduate Students
    • Faculty
    • Staff

    BIOMED PhD Research Proposal

    Title:
    Pathogenicity Classification of Somatic Mutations in Precision Medicine

    Speaker:
    Ashkan Bigdeli, PhD Candidate
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Advisors:
    Ahmet Sacan, PhD
    Associate Teaching Professor
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Uri Hershberg, PhD
    Associate Professor
    University of Haifa
    School of Biomedical Engineering, Science and Health Systems
    Drexel University

    Robert Babak Faryabi, PhD
    Assistant Professor  
    Perelman School of Medicine
    University of Pennsylvania

    Details:
    The accurate classification of genetic variations identified using next-generation sequencing (NGS) has become integral to diagnostics and prognostics pan-cancer; yet the classification process of these variants remains highly manual, inherently variable, and largely inaccessible outside of specialized laboratories. While variant data consortiums and professional guidelines assist in variant classification there is a critical need for accessible methods that reduce not only the time burden, but also the observed variability in variant classification.

    To this end, we have developed a predictive machine learning algorithm that leverages large pan-cancer cohorts and valuable domain resources to effectively grade the pathogenicity of variants derived from DNA NGS. This work increases the accessibility of variant classification through distributable software and decreases variability and time burden through automation. The ability to use accurate predictive models allows for the high throughput genomic profiling of disease that we seek to apply in adult B-cell Acute Lymphoid Leukemia to stratify risk and explore clinical outcomes.

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  • UREP Drop-in Hours

    Wednesday, December 7, 2022

    3:00 PM-5:00 PM

    Bentley Hall, 2nd Floor

    • Undergraduate Students
    • Graduate Students

    Do you have questions about undergraduate research, fellowships, or enrichment programs? Drop-in hours are a chance to chat with staff and UREP ambassadors and get answers to your questions. Virtual drop-ins are available by request - email urep@drexel.edu to schedule.

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  • Co-op Employment Summary & Planner Due - June to Dec 2022 (Summer/Fall) Graduate Co-op Cycle

    Friday, December 9, 2022

    12:00 AM-12:00 AM

    n/a

    • Everyone
    • Graduate Students

    June to December 2022(Summer/Fall) graduate co-op students, the Employment Summary & Planner (ES&P) is due December 9, 2022 in SCDConline. The ES&P is mandatory to receive credit for the co-op experience. For questions, please contact the co-op advisor.

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Graduate College Events Calendar