Professor Sorin Siegler, Ph.D, PI, in conjunction with Professor Giuseppe Palmese, PhD, co-PI and a team of medical and veterinary professionals at the University of Pennsylvania, Penn State and Thomas Jefferson University including Dr Keith Wapner, MD, Dr Christopher Jones, MD, Dr Michael Ciccotti, MD, Dr Jarrett Cain, MD, and Dr Thomas P. Shaer, VMD, (all co-PI) as well as commercial advisor Brian Garvey, CEO, Kinos Medical, received a grant from The Coulter Foundation entitled "Orthopedic Surgical Devices with Controlled Fluid-Induced Expansion Properties for Improved Bone Fixation and Bone Integration." The grant will support research to develop a family of bone fixation products that will improve the outcome of orthopedic surgery using a porous co-polymer with controlled fluid-induced expansion properties as part of the bone-fixation mechanism. Fixation to bone is fundamental in many orthopedic applications such as re-attachment of torn tendons and ligaments and repair of osteochondral defects, but conventional bone fixation systems use engineering materials such as titanium and PEEK that have inherent deficiencies such as poor fixation strength in low-density bone, stress shielding inducing bone resorption, and lack of osteointegration that can give rise to surgery-related failures characterized by anchor pullout, graft subsidence, and implant loosening.
Products developed by this grant aim to improve surgical outcomes by increasing fixation strength to bone, preventing bone resorption, and promoting osteointegration, particularly with the development of improved suture anchors and repair of osteochondral defects. This will impact thousands of patients undergoing orthopedic procedures that require bone fixation from such as rotator cuff repairs, ligament repairs, and tendon transfers.
For more details please contact Professor Siegler at sieglers@drexel.edu.