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The A. Mortensen Lab Publications

(We publish under the name Fontana, AC)

"Transport rate of EAAT2 is regulated by amino acid located at the interface between the scaffolding and substrate transport domains"
Duffield M, Patel A, Mortensen OV, Schnur D, Gonzalez A, Torres-Salazar D, Fontana, ACK
Neurochem Int.104792. doi: 10.1016/j.neuint.2020.104792 (Jul 12, 2020)

"Elucidation of the structure and synthesis of neuroprotective low molecular mass components of the Parawixia bistriata spider venom"
Forster YM, Green JL, Khatiwada A, Liberato JL, Reddy PAN, Salvino JM, Bienz S, Bigler L, Dos Santos WF, Fontana ACK.
ACS Chem Neurosci. doi: 10.1021/acschemneuro.0c00007. PubMed PMID: 32343555 (Apr 28, 2020)

Digitally reconstructed neurons associated with peer-reviewed publications from A. Mortensen Lab
NeuroMorpho.Org, release v.8.0 (37 cells) (February 28, 2020)

"Novel positive allosteric modulators of glutamate transport have in vitro neuroprotective properties in an in vitro excitotoxic model"
Falcucci RM, Wertz R, Green J, Salvino JM, Meucci O, Fontana AC
ACS Chem Neurosci.. doi: 10.1021/acschemneuro.9b00061. [Epub ahead of print]. PMID: 31257852 (Jul 1, 2019)

"Identification of a Novel Allosteric Modulator of the Human Dopamine Transporter"
Aggarwal S, Liu X, Rice C, Menell P, Clark PJ, Paparoidamis N, Xiao YC, Salvino JM, Fontana ACK, España RA, Kortagere S, Mortensen OV
ACS Chem Neurosci. doi: 10.1021/acschemneuro.9b00262. [Epub ahead of print]. PMID: 31184115 (Jun 24, 2019)

"Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures"
Primini, EO, Liberato, JL, Fontana, ACK & Santos, WF
Journal of Venomous Animals and Toxins Including Tropical Diseases, 25, e148818 (2019)

"Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity by Activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt Signaling Pathways"
Ferreira RS, Dos Santos NAG, Bernardes CP, Sisti FM, Amaral L, Fontana ACK, Dos Santos AC
Neurotox Res. doi: 10.1007/s12640-019-00042-w. PubMed PMID: 31016689 (Apr 23, 2019)

"Parawixin2 Protects Hippocampal Cells in Experimental Temporal Lobe Epilepsy"
Liberato JL, Godoy LD, Cunha AOS, Mortari MR, de Oliveira Beleboni R, Fontana ACK, Lopes NP, Dos Santos WF
Toxins (Basel), 10(12). pii: E486. doi: 10.3390/toxins10120486 (Nov 22, 2018)

"Protocols for Measuring Glutamate Uptake: Dose-Response and Kinetic Assays in In Vitro and Ex Vivo Systems"
Fontana ACK
Curr Protoc Pharmacol.;82(1):e45. doi: 10.1002/cpph.45. Epub 2018 Aug 27. PMID: 30152172 (Sep 2018)

"Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2"
Kortagere S, Mortensen OV, Xia J, Lester W, Fang Y, Srikanth Y, Salvino JM, Fontana ACK
ACS Chem Neurosci.;9(3):522-534. doi: 10.1021/acschemneuro.7b00308. Epub 2017 Nov 30.PMID: 29140675 (Mar 21, 2018)

"Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems"
Fontana, AC
Book: Biochemical Approaches for Glutamatergic Neurotransmission, ed. S. Parrot, Denoroy, Luc 2017: Humana Press. ISBN: 978-1-4939-7228-9, doi: 10.1007/978-1-4939-7228-9

"Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission"
Pizzo AB, Beleboni RO, Gomes Carolino RO, de Oliveira L, Miranda A, Coutinho-Netto J, Fontana ACK, Dos Santos WF.
J Biochem Mol Toxicol. doi: 10.1002/jbt.21941 (Jun 16, 2017)

"Current approaches to enhance glutamate transporter function and expression"
Fontana AC
J Neurochem. doi:10.1111/jnc.13200 (June 20, 2015)

"Neuroprotective effects of the glutamate transporter activator, MS-153, following traumatic brain injury in the adult rat"
Fontana AC, Fox DP, Zoubroulis A, Mortensen OV, Raghupathi R
J Neurotrauma (July 22, 2015)

"Molecular determinants of transport stimulation of EAAT2 are located at interface between the trimerization and substrate transport domains"
Mortensen OV, Liberato JL, Coutinho-Netto J, Dos Santos WF, Fontana AC
J Neurochem. 133(2):199-210. doi:10.1111/jnc.13047. Epub 2015 Feb 26. PubMed PMID:25626691 (April 2015)

"The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities"
Timple JM, Magalhães LG, Souza Rezende KC, Pereira AC, Cunha WR, Andrade e Silva ML, Mortensen OV, Fontana AC
J Nat Prod. 76(10):1889-95. doi:10.1021/np400452n. Epub 2013 Oct 10 (October 25, 2013)

"Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action"
Kortagere S, Fontana AC, Rose DR, Mortensen OV
Neuropharmacology. 72C:282-290. doi:10.1016/j.neuropharm.2013.04.026 (2013)

"A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants"
Larsen MB, Fontana AC, Magalhães LG, Rodrigues V, Mortensen OV
Mol Biochem Parasitol. 177(1):35-41 (2011)

"Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin"
Fontana AC, Sonders MS, Pereira-Junior OS, Knight M, Javitch JA, Rodrigues V, Amara SG, Mortensen OV
Eur J Pharmacol. 616(1-3):48-57 (2009)

"Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom"
Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG
Mol Pharmacol. 72(5):1228-37 (2007)

"Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycine"
de O Beleboni R, Guizzo R, Fontana AC, Pizzo AB, Carolino RO, Gobbo-Neto L, Lopes NP, Coutinho Netto J, Dos Santos WF
Mol Pharmacol. 69(6):1998-2006 (2006)

"Spider and wasp neurotoxins: pharmacological and biochemical aspects" (Review)
de O Beleboni R, Pizzo AB, Fontana AC, de O G Carolino R, Coutinho-Netto J, Dos Santos WF
Eur J Pharmacol. 493(1-3):1-17 (2004)

"Characterization of the actions of AvTx 7 isolated from Agelaia vicina (Hymenoptera:Vespidae) wasp venom on synaptosomal glutamate uptake and release"
Pizzo AB, Beleboni RO, Fontana AC, Mussi A, Coutinho-Netto J, Miranda A, Santos WF
J Biochem Mol Toxicol. 18(2):61-8 (2004)

"Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake"
Fontana AC, Guizzo R, de Oliveira Beleboni R, Meirelles E Silva AR, Coimbra NC, Amara SG, dos Santos WF, Coutinho-Netto J
Br J Pharmacol. 139(7):1297-309 (2003)

"P. bistriata and venoms: purification, inhibition of GABA uptake and in vivo anticonvulsant effect"
Cairrao, MAR; Ribeiro, AM; Pizzo, A; Fontana, AC; Beleboni, RO; Coutinho-Netto, J; Miranda, A; Santos, WF
Pharmaceutical Biology. 40(6):472-477 (2002)

"Excitatory amino acid transporters: keeping up with glutamate" (Review)
Amara SG, Fontana AC
Neurochem Int. 41(5):313-8 (2000)

"Effects of the crude venom of the social wasp Agelaia vicina on gamma-aminobutyric acid and glutamate uptake in synaptosomes from rat cerebral cortex"
Pizzo AB, Fontana AC, Coutinho-Netto J, dos Santos WF
J Biochem Mol Toxicol. 14(2):88-94 (2000)

"Paralizing activity of the Parawixia bistriata crude venom in termites: a new bioassay"
Fontana AC, Cairrao MA, Colusso AJ, Santos WF, Coutinho-Netto J
Toxicon. 38(1):133-8 (2000)

 
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