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The A. Mortensen Lab News & Announcements

April 2021

Congratulations Katelyn Reeb

Katie was a runner-up in the Science Sketch Competition of the Philadelphia chapter of the Society for Neuroscience (PCSFN) for her submission titled, “The mechanism of allosteric modulation of glutamate transporters.” Check out Katie's sketch at the links below:

September 2020

NIDA Grant

Our collaborative grant with Dr. Scott Rawls at Temple University was funded! In this RO1, we will study non-beta-lactam GLT-1 activators, including our positive allosteric modulators, in preclinical models of opioid and cocaine addiction.

July 2020

Bhumi Patel Defends Her Master’s Thesis

Congratulations to Bhumi for a successful thesis defense, titled "The Role of Glutamate Transporters in Neuroprotection After in vitro Stroke and Cocaine Seeking Behavior in vivo."

Bhumi Patel, A. Mortensen Lab member, presenting her master's thesis via Zoom

March 2020

Katie Gives a Rotation Talk

Congratulations to Katie for giving a terrific rotation talk! The wonderful news is that she has chosen to stay in our lab for her PhD thesis, and we are thrilled!

Katelyn Reeb, A. Mortensen lab member, delivering a rotation talk

December 2019

NINDS Grant

We are glad to announce that our lab was awarded a RO1 grant from NINDS for the project “The mechanism of allosteric modulation of glutamate transporters”

This collaborative project with Olga Boudker (Cornell) and Nico Reyes (Bordeaux) will use structure/function, FRET and crystallography studies to understand the molecular mechanisms of allosteric modulation of glutamate transporters, using positive and negative allosteric modulators as tools.

This work will provide an understanding of glutamate transport mechanisms, and this information may generate new avenues for drug discovery, as these transporters serve as important drug target for many severe, debilitating CNS conditions.

November 2019

Discovery Day

Bhumi presented a poster at Discovery Day, the College of Medicine's annual day of research, held at the Pennsylvania Convention Center on November 7. The poster highlighted Bhumi's work with mGluRs and cocaine addiction in vivo.

Bhumi Patel, Andreia Mortensen Lab member, with her poster at Discovery Day 2019

October 2019

Society for Neuroscience

Andreia and Jennifer attended the Society for Neuroscience annual meeting in Chicago, and presented a poster, "Development of broad activity positive allosteric modulator of glial glutamate transporters EAAT1 and EAAT2."

Jennifer Green and Andreia Mortensen with their poster at the 2019 Society for Neuroscience meeting

Mid-Atlantic Pharmacology Society Meeting

Bhumi presented a scientific poster at the Mid-Atlantic Pharmacology Society (MAPS) meeting at Temple University. Her poster was “The Role of Glutamate Transporters in Neuroprotection After in vitro Stroke and Cocaine Addiction in vivo.”

Bhumi Patel with her poster at the Mid-Atlantic Pharmacology Society's meeting

June 2019

Jennifer Green Defends Thesis and Receives Honor

Jennifer Green successfully defended her master's thesis in Drug Discovery and Development on June 12, 2019. Jennifer received the award for Outstanding Achievement in Drug Discovery and Development this year.

Jennifer Green and Andreia Mortensen celebrate Jennifer's successful thesis defenseJennifer Green and her mother with her Drug Discovery & Development Award in Philadelphia
Left: Jennifer Green and Andréia Mortensen celebrate Jennifer's successful thesis defense. Right: Jennifer and her mother with her award in Philadelphia.

December 2018

Secret Santa

Mortensen Lab Secret Santa 2018Mortensen Lab Secret Santa 2018Mortensen Lab Secret Santa 2018

End of the year Secret Santa in the lab. Happy 2019!

October 2018

Discovery Day

Jennifer Green presented a poster at Discovery Day, the College of Medicine's annual day of research, on October 23 at the Pennsylvania Convention Center.

Jennifer Green with her poster at Discovery Day 2018

August 2018

Successful Thesis Defense

Apeksha Khatiwada successfully defended her master's thesis on August 10, 2018. Congratulations Apeksha, we will miss you!

Apeksha Khatiwada defending her thesis

Cover of book published with a chapter by A. Mortensen, Biochemical Approaches for Glutamatergic Neurotransmission

October 2017

Book Published

The new book, Biochemical Approaches for Glutamatergic Neurotransmission, in which Dr. Mortensen has authored a chapter titled "Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems," has been published.

The book is available on the Springer website.

July/September 2017

Successful Thesis Defenses

Congratulations to Ryan Wertz and Mike Duffield, who defend their master's theses in July and September of 2017, respectively.

Good luck on your new endeavors, Ryan and Mike!

Ryan Wertz and Mike Duffield at their thesis defenses

January 2017

Happy New Year!

Our lab and Dr. Ole Mortensen’s lab went for lunch in early January to welcome 2017 and wish all a happy and productive year!

The Mortensen Labs enjoy lunch to ring in the new year

New Book Chapter Accepted for Publication

Dr. Andréia Mortensen wrote a chapter entitled “Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems,” which was accepted for publication in the book Biochemical Approaches for Glutamatergic Neurotransmission.

The book will be published by Springer Business + Science Media in spring of 2017.

November 2016

Society for Neuroscience 2016

Our lab was selected to present a Neuroscience 2016 Hot Topic at the annual Society for Neuroscience Meeting, which was held November 12–16 in San Diego, Calif. Our presentation is entitled "Neuroprotective properties of novel positive allosteric modulators of EAAT2.

The A. Mortensen Lab at SfN 2016 in San Diego

October 2016

Coulter Funding Received

Our lab received an award from the Coulter program for the in-life, plasma and brain exposure studies (oral and IV) and ADME assays of novel EAAT2 activators.

Discovery Day 2016

Ryan Wertz presented a poster at Discovery Day on October 20, 2016, at the Pennsylvania Convention Center, entitled “Characterization of in vitro neuroprotective properties of novel positive allosteric modulators of EAAT2.” Congratulations, Ryan, on your presentation!

Ryan Wertz presented a poster at Discovery Day on October 20, 2016, at the Pennsylvania Convention Center

June 2016

CURE Funding received

Our lab was awarded a CURE Grant (Commonwealth of Pennsylvania) entitled “Novel allosteric modulator of glutamate transporter EAAT2 for neuroprotection after brain trauma.” The project will be performed in collaboration with Dr. Ramesh Raghupathi and Dr. Joseph Salvino.