News & Announcements
Congratulations Katelyn Reeb
Katie was a runner-up in the Science Sketch Competition of the Philadelphia chapter of the Society for Neuroscience (PCSFN) for her submission titled, “The mechanism of allosteric modulation of glutamate transporters.” Check out Katie's sketch at the links below:
Our collaborative grant with Dr. Scott Rawls at Temple University was funded! In this RO1, we will study non-beta-lactam GLT-1 activators, including our positive allosteric modulators, in preclinical models of opioid and cocaine addiction.
Bhumi Patel Defends Her Master’s Thesis
Congratulations to Bhumi for a successful thesis defense, titled "The Role of Glutamate Transporters in Neuroprotection After in vitro Stroke and Cocaine Seeking Behavior in vivo."
Katie Gives a Rotation Talk
Congratulations to Katie for giving a terrific rotation talk! The wonderful news is that she has chosen to stay in our lab for her PhD thesis, and we are thrilled!
We are glad to announce that our lab was awarded a RO1 grant from NINDS for the project “The mechanism of allosteric modulation of glutamate transporters”
This collaborative project with Olga Boudker (Cornell) and Nico Reyes (Bordeaux) will use structure/function, FRET and crystallography studies to understand the molecular mechanisms of allosteric modulation of glutamate transporters, using positive and negative allosteric modulators as tools.
This work will provide an understanding of glutamate transport mechanisms, and this information may generate new avenues for drug discovery, as these transporters serve as important drug target for many severe, debilitating CNS conditions.
Bhumi presented a poster at Discovery Day, the College of Medicine's annual day of research, held at the Pennsylvania Convention Center on November 7. The poster highlighted Bhumi's work with mGluRs and cocaine addiction in vivo.
Society for Neuroscience
Andreia and Jennifer attended the Society for Neuroscience annual meeting in Chicago, and presented a poster, "Development of broad activity positive allosteric modulator of glial glutamate transporters EAAT1 and EAAT2."
Mid-Atlantic Pharmacology Society Meeting
Bhumi presented a scientific poster at the Mid-Atlantic Pharmacology Society (MAPS) meeting at Temple University. Her poster was “The Role of Glutamate Transporters in Neuroprotection After in vitro Stroke and Cocaine Addiction in vivo.”
Jennifer Green Defends Thesis and Receives Honor
Jennifer Green successfully defended her master's thesis in Drug Discovery and Development on June 12, 2019. Jennifer received the award for Outstanding Achievement in Drug Discovery and Development this year.
Left: Jennifer Green and Andréia Mortensen celebrate Jennifer's successful thesis defense. Right: Jennifer and her mother with her award in Philadelphia.
End of the year Secret Santa in the lab. Happy 2019!
Jennifer Green presented a poster at Discovery Day, the College of Medicine's annual day of research, on October 23 at the Pennsylvania Convention Center.
Successful Thesis Defense
Apeksha Khatiwada successfully defended her master's thesis on August 10, 2018. Congratulations Apeksha, we will miss you!
The new book, Biochemical Approaches for Glutamatergic Neurotransmission, in which Dr. Mortensen has authored a chapter titled "Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems," has been published.
The book is available on the Springer website.
Successful Thesis Defenses
Congratulations to Ryan Wertz and Mike Duffield, who defend their master's theses in July and September of 2017, respectively.
Good luck on your new endeavors, Ryan and Mike!
Happy New Year!
Our lab and Dr. Ole Mortensen’s lab went for lunch in early January to welcome 2017 and wish all a happy and productive year!
New Book Chapter Accepted for Publication
Dr. Andréia Mortensen wrote a chapter entitled “Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems,” which was accepted for publication in the book Biochemical Approaches for Glutamatergic Neurotransmission.
The book will be published by Springer Business + Science Media in spring of 2017.
Society for Neuroscience 2016
Our lab was selected to present a Neuroscience 2016 Hot Topic at the annual Society for Neuroscience Meeting, which was held November 12–16 in San Diego, Calif. Our presentation is entitled "Neuroprotective properties of novel positive allosteric modulators of EAAT2.
Coulter Funding Received
Our lab received an award from the Coulter program for the in-life, plasma and brain exposure studies (oral and IV) and ADME assays of novel EAAT2 activators.
Discovery Day 2016
Ryan Wertz presented a poster at Discovery Day on October 20, 2016, at the Pennsylvania Convention Center, entitled “Characterization of in vitro neuroprotective properties of novel positive allosteric modulators of EAAT2.” Congratulations, Ryan, on your presentation!
CURE Funding received
Our lab was awarded a CURE Grant (Commonwealth of Pennsylvania) entitled “Novel allosteric modulator of glutamate transporter EAAT2 for neuroprotection after brain trauma.” The project will be performed in collaboration with Dr. Ramesh Raghupathi and Dr. Joseph Salvino.