We are looking for a postdoctoral researcher to join our team. Learn more.
Current Lab Members
Simran Gill is a master’s student in the Drug Discovery & Development program in our department, working on a project to characterize modulation of the expression of glutamate transporters and compensatory mechanisms associated with in vitro models of stroke.
Katelyn (Katie) is a PhD student in the Department of Pharmacology & Physiology, performing a rotation project in the lab. Her project proposes to investigate the modulation of glutamate transporters in in vitro models of epilepsy, using calcium imaging and immunocytochemistry. Her project also involves mutagenesis studies to further define the allosteric site within glutamate transporter EAAT2.
Rhea Temmermand is a PhD student in the Department of Pharmacology & Physiology working toward a rotation project in our lab. Her project proposes to examine the modulation of glutamate transporters in an in vitro model of stroke in primary glial cultures. She is also interested in understanding the effect of volatile anesthetics on glutamate transporters in the CNS and possible adverse effects.
Past Lab Members
Bhumi was a Drug Discovery & Development master's student in the Department of Pharmacology & Physiology who graduated in 2020. Her project involved examining the role of glutamate transporters in drug addiction using models such as conditioned place preference, and understanding the role of metabotropic glutamate receptors and glutamate transporters in neuroprotection in in vitro stroke models. Bhumi is currently pursuing a PhD in cell biology and neuroscience at Rowan University.
Jennifer was a Drug Discovery & Development master's student in the Department of Pharmacology & Physiology until December 2019. Her project involved screening studies of allosteric modulators of glutamate transporters, using the Cell Insight CX7 High-Content Screening (HCS) Platform. Jennifer is currently pursuing a PhD in pharmacology and molecular signaling at Columbia University.
Alethia was a PhD student in the Department of Pharmacology & Physiology doing a rotation study in the lab. Her project proposed to understand differences in sodium-dependence of mutated EAAT2 transporters that have different activity levels. This project has implications for understanding mechanisms for glutamate transport upregulation and, as a result, how to target EAAT2 for neuroprotective strategies in the future.
Julia was a PhD student in the Department of Pharmacology & Physiology doing a rotation study in the lab. Her project proposed to elucidate molecular determinants in the glutamate transporters involved in allosteric modulation. For that project, Julia used computational modeling and performing docking studies, as well doing glutamate transport experiments with mutants and wild type transporters in presence of allosteric modulators. This project has implications for future development of therapies based on allosteric modulation of glutamate transporters.
Shunyi was a master's student in the Department of Pharmacology & Physiology. His project involved understanding the role of metabotropic glutamate receptors and glutamate transporters in neuroprotection in in vitro models of stroke.
Apeksha was a Drug Discovery and Development master's student in the Department of Pharmacology & Physiology. She joined the lab to perform screening studies of allosteric modulators of glutamate transporters, using overexpressing cells and glial cultures.
Zoe was a MLAS graduate from Drexel who joined our lab to work on the project supported by CURE: "Novel Allosteric Modulator of Glutamate Transporter EAAT2 for Neuroprotection after Brain Trauma." Her work involved performing in vivo animal studies of traumatic brain injury and in vitro studies with neuron/glia cultures.
Srawasti was a Master of Science in Medical Science student at Drexel University College of Medicine. She joined the lab to study potential neuroprotection of novel allosteric activators of glutamate transport in in vitro models of stroke in primary neuronal cultures.
January 2016 – July 2017
Ryan defended his master's thesis for the Drug Discovery and Development program entitled "Advances in drug development of positive allosteric modulators of EAAT2: in vitro neuroprotection studies" in July 2017. He then joined the Department of Pharmacology and Toxicology at the Medical College of Wisconsin.
July 2016 – May 2017
Rebisi graduated with a Master Science in Medical Science degree from Drexel University College of Medicine and is currently looking at admission into medical school. He joined the lab to study potential neuroprotection of novel allosteric activators of glutamate transport in in vitro models of epilepsy and stroke.
Rafaela Scalco Ferreira
March 2017 – August 2017, Exchange Student
Rafaela was a PhD student from Brazil who developed a four-month work/study project in the lab, focusing on learning cell transfection techniques and neurotransmitter transporter-based assays. She examined the actions of cisplatin and caffeic acid phenethyl ester (CAPE), which are relevant for cancer research.
Summer of 2017 SURF Student
Cassie joined our lab on the SURF program to work on the project "Positive allosteric modulation of glutamate transport for neuroprotection: Potential therapy for brain injury." She focused her efforts on histological studies of rats subjected to lateral fluid percussion injury. She then returned to the University of Scranton to finish her major in neuroscience.
Romulo Martelli Falcucci
January 2015 – May 2016
Romulo defended his Drug Discovery and Development master's thesis entitled "Neuroprotective properties of novel positive allosteric modulators of EAAT2" in May 2016. He is currently working at Janssen R&D in São Paulo, Brazil, in clinical trials of esketamine in patients with treatment-resistant/severe depression.
July 2015 – May 2016
Avkash graduated from the Master of Medical Science program and was admitted to the Drexel University College of Medicine Class of 2020.
January 2014 – January 2016
Project: "Molecular Mechanisms of glutamate transport enhancement"
Program: Master of Science in Drug Discovery and Development / Pharmacology and Physiology
Current position: Research assistant at Rockefeller University
July 2015 – December 2015
Rotation project: "Small Molecule Activator of EAAT2 is Neuroprotective in an in vitro model of NMDA excitotoxicity"
Program: PhD student lab rotation / Pharmacology and Physiology
Current position: Graduate student in the Pharmacology & Physiology program in Ole Mortensen's lab
Summer of 2015
Project: "Optimization and development of in vitro efficacy assays for neuroprotection in primary cortical neuronal cultures"
Program: SURF (Summer Undergraduate Research Fellowship)
Current position: Graduate student at University of Notre Dame
2013 – 2014
Project: "Effects of MS-153 on the pathophysiology of Traumatic Brain Injury in rats"
Program: Master of Science in Biomedical Engineering / Pharmacology and Physiology
Current position: Research assistant at Wills Eye Hospital
2013 – 2014
Project: "Pharmacological characterization of novel glutamate transporter modulators"
Current position: MS student lab rotation / Pharmacology and Physiology
Mateus Amaral Baldo
December 2013 – March 2014
Project: "Pharmacological characterization of neurotoxins isolated from the venom of Rhinella schneideri (Anura: Bufonidae) frog on neurotransmitter transporters"
Program: Exchange Student Program Award sponsored by CAPES, Brazil
Current position: Teaching professor at Universidade Paulista, Brazil
2012 – 2013
Project: "Glutamate transport activation as therapy for traumatic brain injury- Histological studies"
Program: Master of Science in Medical Science / Pharmacology and Physiology
Current position: Medical student at Lincoln Memorial University DeBusk College of Osteopathic Medicine
2012 – 2013
Project: "Role of cubebin derivatives on the modulation of biogenic amine transporters"
Program: Master of Science in Interdisciplinary Health Sciences / Pharmacology and Physiology
Current position: Medical student at Alabama College of Osteopathic Medicine
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