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The Fischer Lab Publications: Neural Stem Cells


Vascularization of self-assembled peptide scaffolds for spinal cord injury repair
Tran KA, Partyk PP, JinY, Bouyer J, Fischer I, Galie PA
(2020) Acta Biomaterialia. PMID 31904559 DOI: 10.1016/j.actbio.2019.12.033

Harnessing neurovascular interaction to guide axon growth
Partyka PP, Jin Y, Bouyer J, DaSilva A, GodseyGA, Nagele RG, Fischer I, Galie PA
(2019) Scientific Reports DOI:10.1038/s41598-019-38558-y. Impact – 5.

Combining Neural Transplantation with Therapeutic Intermittent Hypoxia to Treat the Injured Spinal Cord
Zholudeva LV, Randelman M, Dilbarova R, Caplan M, Qiang L, I Fischer I, Lane MA
(2019) Cell Transplantation 28 (4), 491-491

Axonal regeneration of different tracts following transplants of human glial restricted progenitors into the injured spinal cord in rats
Jin Y, Shumsky JS, Fischer I
(2018) Brain Res. 2018 May 1;1686:101-112. doi: 10.1016/j.brainres.2018.01.030. Epub 2018 Feb 1

Heptamer peptide disassembles native amyloid in human plasma via Heat Shock Protein 70
Cunningham TJ, Greenstein J, Yao L, Fischer I, Connors T
(2018) Rejuvenation Res. 2018 May 30. doi: 10.1089/rej.2017.2049. [Epub ahead of print].

Transplantation of Neural Progenitors and V2a Interneurons after Spinal Cord Injury
Zholudeva LV, Iyer N, Qiang L,, Spruance VM, Randelman ML, White NW, Bezdudnaya T1,, Fischer I, Sakiyama-Elbert SE, Lane MA
(2018) J Neurotrauma. 2018 Aug 10. doi: 10.1089/neu.2017.5439. [Epub ahead of print].

Neural progenitor cells promote growth and alter axonal mRNA localization in adult neurons
Marianda TT, Jin Y. Kalinski AL, Fischer I, Twiss JL 
(2017) eNeuro 4(1) DOI: 10.1523/ENEURO.0171-16.201

Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion
Jin Y, Bouyer J, Haas C, Fischer I.
(2015) Experimental Neurol. 257, 175-188.

Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors
Hayakawa K, Haas C, Ying Jin1, Bouyer J, Otsuka T, Fischer I.
(2015) Brain Res. 2015 Oct 21. pii: S0006-8993(15)00766-0. doi: 10.1016/j.brainres.2015.10.022. [Epub ahead of print] PMID: 26498878

Transplantation of neural progenitor cells in chronic spinal cord injury
Jin Y, Bouyer J, Shumsky JS, Haas C, and Fischer I.
(2015) Neuroscience 2016.01.066. Epub 2016 Feb 4. PMID:26852702

Guiding migration of transplanted glial progenitor cells in the injured spinal cord
Yuan X, Haas C, Ying Jin1, Yao L, Hayakawa K, Wangm Y, Wang C, Fischer I.
(2015) Science Report 6:22576

Transplanting neural progenitors into a complete transection model of spinal cord injury
Medalha CC, Y Jin, T Yamagami, C Haas, I Fischer
(2014) J Neurosci Res. 92(5):607-18

Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat
Jin Y, J Bouyer, C Haas, and I Fischer
(2014) Exp Neurol. 257:57-69

Ghobrial G, C Haas, C Maulucci, A Lepore, I Fischer, and J Harrop. 2014 Promising advances in targeted cellular based therapies: Treatment update in spinal cord injury. Journal of Stem Cell Research and Therapy 4:170. doi: 10.4172/2157-7633.1000170

Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL, Consortium M, Abeyruwan SW, Beattie MS, Bethea J, Bradke F, Bresnahan JC, Bunge MB, Callahan A, David S, Dunlop SA, Fawcett J, Fehlings M, Fischer I, Giger RJ, Goshima Y, Grimpe B, Hagg T, Hall ED, Harrison BJ, Harvey AR, He C, He Z, Hirata T, Hoke A, Hulsebosch CE, Hurtado A, Jain A, Kadoya K, Kamiguchi H, Kengaku M, Kocsis JD Ph D, Kwon BK, Lee JK, Liebl DJ PhD, Liu SJ, Lowery LA, Mandrekar-Colucci S, Martin JH, Mason CA, McTigue DM, Mokarram N, Moon LD, Muller HW, Nakamura T, Namba T, Nishibe M, Oinuma I, Oudega M, Pleasure DE, Raisman G, Rasband MN, Reier PJ, Santiago-Medina M, Schwab JM, Schwab ME, Shinmyo Y, Silver J, Smith GM, So KF, Sofroniew MV Md PhD, Strittmatter SM, Tuszynski MH, Twiss JL, Visser U, Watkins TA, Wu W, Yoon SO, Yuzaki M, Zheng B, Zhou F, Zou Y. 2014. Minimum Information About a Spinal Cord Injury Experiment (MIASCI) – a proposed reporting standard for spinal cord injury experiments. J. Neurotrauma 2014 May 28. [Epub ahead of print] PMID: 24870067.

Haas C and Fischer I. 2013. Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. Journal of Neurotrauma. Jun 15;30(12):1035-52. doi: 10.1089/neu.2013.2915. Epub 2013 Jun 12. PMID: 23635322

Ketschek A, Gallo G, Fischer I. 2012. Neural precursors extend neurites that cross Chondroitin Sulfate Proteoglycan border. Exp Neurol. 235:627-37. PMC3345077

Jin Y, Sura K, Fischer I. 2012. Differential Effects of Distinct CNS Regions on Cell Migration and Axonal Extension of Neural Progenitor Transplants. J Neurosci Res. 2012 Nov;90(11):2065-73. doi: 10.1002/jnr.23099. Epub 2012 Jun 27. PMC3439565

Saglam A, Perets A, Canver AC, Li H, Kollins K, Cohen G, Fischer I, Lazarovici P, and Peter I. Lelkes PI. 2012. Angioneural Crosstalk in Scaffolds with Oriented Microchannels for Regenerative Spinal Cord Injury Repair. J Mol Neurosci. Feb;49(2):334-46. doi: 10.1007/s12031-012-9863-9. Epub 2012 Aug 10.

Francis NL, Shanbhag MS, Fischer I, and Wheatley MA. 2011. Influence of alginate cross-linking method on neurite response to microencapsulated neurotrophin-producing fibroblasts. J. Microencapsulation. 28(5):353-62. PMID: 21736520

Jin Y, Neuhuber B, Singh A, Bouyer J, Bonner J, Himes BT, Campanelli JT, Fischer I. 2011. Transplantation of human glial restricted progenitors and astrocytes into spinal cord contusion. J. Neurotrauma. 28(4):579-94. PMCID: PMC3070147

Lepore AC, O’Donnell, J, Bonner JF, Courtney P, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. 2011. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter, GLT1, following traumatic spinal cord injury. The Journal of Neuroscience Research. 89(7):1001-17. PMID: 21488085

Jin Y, Ketschek A, Jiang Z, Smith G, Fischer I. 2011. Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo. J Neurosci Methods. 15;199(2):208-13. PMCID: PMC3138860

Bonner JF, Connors TM, Silverman WF, Kowalski DP, Lemay MA, and Fischer I. 2011. Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord. J Neuroscience. 31:4675-4686. PMCID: PMC3148661

Conova L, Vernengo J, Jin Y, Himes BT, Neuhuber B, Fischer I, Lowman A. 2011 A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord. J Neurosurg Spine 15:594-604. PMID:21888482

Haas C, Neuhuber B, Yamagami T, Rao M, Fischer I. 2011. Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration. Experimental Neurol. 233:717-732.  PMCID: PMC3272137

Mitsui T, Neuhuber B, Fischer I. 2011. Acute administration of AMPA/Kainate blocker combined with delayed transplantation of neural precursors improves lower urinary tract function in spinal injured rats. Brain Research. 1418:23-31. PMCID: PMC3185105.

See J., M. Neuhuber B, Bonner, and I. Fischer. 2010. Neurite outgrowth of neural progenitors in presence of inhibitory proteoglycans. Journal of Neurotrauma 27(5):951-57. PMID:20102265.

Bonner JF, Blesch A, Neuhuber B, Fischer I. 2009. Promoting directional axon growth from neural progenitors grafted into the injured spinal cord. Journal of Neuroscience Research 88(6):1182-92. PMCID: PMC2844860

Comolli, N. K., B. Neuhuber, I. Fischer, and A. M. Lowman. 2008. In vitro analysis of a novel injectable polymeric scaffold for spinal cord repair. Acta Biomater. 5(4):1046-1055.  [Epub ahead of print] PMCID: PMC2844850

Lepore AC, Neuhuber B, Connors TM, Han SSW, Liu Y, Daniels MP, Rao MS, Fischer I.  (2006). Long-term Fate of Neural Precursor Cells Following Transplantation into Developing and Adult CNS. Neuroscience 139:513-530.

Park KI, Himes BT, Stieg PE, Tessler A, Fischer I, Snyder EY. (2006). Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Exp. Neurol. 199(1):179-190.

Coksaygan T, Magnus T, Cai J, Mughal M, Lepore A, Xue H, Fischer I, Rao MS. (2006). Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury. Exp. Neurol. Exp Neurol.197:475-85.

Lepore AC, Walczak P, Rao MS, Fischer I, Bulte JWM. (2006) MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord. Exp Neurol 201(1):49-59.

Li P, Tessler A, Han SSW, Fischer I, Rao MS, Selzer ME. (2005). Fate of immortalized human neuronal progenitor cells transplanted into rat spinal cord. Arch Neurol 62:223-229.

Lepore A, Fischer I. (2005). Lineage-restricted neural precursors survive, migrate and differentiate following transplantation into the injured adult spinal cord. Exp Neurol 194:230-242.

Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M, Privat A, Reier P, Steeves J, Steward O, Tetzlaff W, Tuszynski MH, Waxman SG, Whittemore S, Wolpaw J, Young W, Zheng B. (2005). Recommended guidelines for studies of human subjects with spinal cord injury.Spinal Cord 43: 453-458.

Lepore AC, Bakshi A, Swanger SA, Rao MS, Fischer I. (2005). Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res. 1045:206-216.

Mitsui T, Shumsky JS, Lepore A, Murray M, Fischer I. (2005). Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity and modifies intraspinal circuitry. J. Neurosci. 25: 9624-9636

Nothias, J-M, Mitsui T, Shumsky JS, Fischer I, Antonacci MD, Murray M. (2005). Combined effects of neurotrophin secreting transplants, exercise and serotonergic drug challenge improve function in spinal rats. Neurorehab Neur Rep. 19:296-312.

Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A, Murray M. (2005). Immunosuppression with either cyclosporine A or FK 506 promotes repair processes after spinal cord injury. J. Neurotrauma 22:1267-1281.

Han SS, Liu Y, Tyler-Polsz C, Rao MS, Fischer I (2004). Transplantation of glial-restricted precursor cells into the adult spinal cord: Survival, glial-specific differentiation, and preferential migration in white matter. Glia 45:1-16.

Lepore AC, Han SSW, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I (2004). Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biology 1:113-126.

Dhoot NO, Tobias CA, Fischer I, Wheatley MA. (2004). Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth. J. Biomed Materials Res 71:191-200.

Bakshi A, Fisher O, Dagci T, Himes BT, Fischer I, Lowman A. (2004). Mechanically engineered hydrogel scaffolds can promote axonal growth and angiogenesis after transplantation in spinal cord injury. J. Neurosurgery 3:322-329.

Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I. (2004). Minimally invasive delivery of stem cells for spinal cord injury: Advantages of the lumbar puncture technique. J. Neurosurgery 3:330-337.

Liu Y, Han SSW, Wu Y, Tuohy TMF, Xue H, Cai J, Back SA, Sherman LS, Fischer I, Rao MS. (2004). CD44 expression identifies astrocyte-restricted precursor cells. Develop. Biol. 276:31-36.

Emery DL, Royo NC, Fischer I, Saatman KE, McIntosh TK. (2003). Plasticity following injury to the adult central nervous system: Is recapitulation of a developmental state worth promoting? J Neurotrauma 20:1271-1292.

Mujtaba T, Han SSW, Fischer I, Sandgren EP and Rao MS. (2002) Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat. Exp. Neurol. 174:48-57.

Wu YY, Mujtaba T, Han SSW, Fischer I and Rao MS. (2002) Isolation of a glial-restricted tripotential cell line from embryonic spinal cord cultures. Glia 38:65-79.

Han S.S.W., Kang D., Mujtaba T.,  Rao M.S.,  Fischer I. (2002). Grafted lineage-restricted neuronal precursors generate mature neurons in the adult spinal cord. Exp Neurol 177:360-375.

Hormigo A, McCarthy M, Nothias JM, Hasegawa K, Huang W, Friendlander DR, Fischer I, Fishell G, Grumet M (2001). Radial glial cell line C6-R integrates preferentially in adult white matter and facilitates migration of co-implanted neurons in vivo. Exp. Neurol., 168:310-322.

Review and Books

Fischer I, Haas C, Raghupathi R, Jin Y. (2016) Spinal Cord Concussion: studying the potential risks of repetitive injury. Neural Regeneration Research DOI:10.4103/1673-5374.169634 

Hayakawa K, Haas C, Fischer I (2016) Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury. Neural Regeneration Research (in press)

Jin Y, Bouyer J, Haas C, Fischer I. The “other” concussion: Spinal cord concussion. Atlas of Science.

Haas C, Ghobrial G, Bonner J, Fischer I (2014) "Neural stem cell therapy for spinal cord injury" in "Neural Stem Cells in Health and Disease" Shetty, A Ed. World Scientific. In Press.

Haas C and Fischer I (2014). Transplanting neural progenitors to build a neuronal relay across the injured spinal cord. Neural Regeneration Research 9: 1173-1176.

Bonner JF, Lepore AC, Rao M, Fischer I. (2014). Cellular replacement in spinal cord injury. In: Textbook of Neural Repair and Rehabilitation. Neural Repair and Plasticity. Selzer ME, Clarke S, Cohen LG, Kwakkel G, Miller RH (eds). Pp. 435-456.

Bonner JF, C Haas, and I Fischer. “Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications.” (2013). Methods in Molecular Biology – Neuronal Cell Culture. Volume 1078. Editors: Amini, Shohreh; White Martyn L. Methods Mol Biol. 1078:56-88.

Bonner J and Fischer I. (2013). Transplantation of neural stem cells and progenitors in animal models of disease. In Neural Stem Cell Assays. Kaur, N and Vemuri M eds. Wiley Blackwell. In Press.

Blesch A, Fischer I, Tuszynski MH. (2012) Handbook of Clinical Neurol, Chapter 37: Gene Therapy, Neurotrophic Factors and Spinal Cord Regeneration.

Bonner J, , Lepore AC, Rao M, Fischer I. (2011). Cellular replacement in spinal cord injury. In: Textbook on Neural Repair and Rehabilitation. Neural Repair and Plasticity. Selzer ME, Clarke S, Cohen LG, Duncan PW, Gage FH (eds).

Neuhuber B, and I. Fischer. (2010). Intrathecal delivery of stem cells to the spinal cord. In: K. K. Jain (ed.), Drug delivery to the central nervous system, Series: Neuromethods 45, Humana Press – Springer. Chapter 10:219-232.

Fischer I, Lepore AC, Han SSW, Tessler AR. (2006). Cellular replacement in spinal cord injury. In: Textbook on Neural Repair and Rehabilitation. Neural Repair and Plasticity. Selzer ME, Clarke S, Cohen LG, Duncan PW, Gage FH (eds). Pp. 445-467.

Murray M, Fischer I. (2001). Transplantation and gene therapy: Combined approaches for repair of spinal cord injury. Neuroscientist 7:28-41.

Fischer I, Liu Y (2000) Gene Therapy strategies in CNS axon regeneration. In Nerve Regeneration. Ingoglia N and Murray M (eds). pp. 563-602, Marcel and Dekker.

Fischer I (2000). Candidate cells for transplantation into the injured CNS. In Seil FJ, Ed,  Progress in Brain Research, Neural Plasticity and Regeneration. 128:253-258, Elsevier Science.

Deitch J and Fischer I (1999) Rat fetal hippocampal neurons in IBRO Handbook: The neuron in tissue culture. Haynes LW (ed) John Wiley and Sons.

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