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Ajit Lab Publications

"Hsa-miR-605 regulates the proinflammatory chemokine CXCL5 in complex regional pain syndrome"
Pande R, Parikh A, Shenoda BB, Ramanathan S, Alexander GM, Schwartzman RJ, Ajit SK*
Biomedicine & Pharmacotherapy 2021 Aug;140:111788. doi: 10.1016/j.biopha.2021.111788

"Circulating miRNAs from the mouse tibia fracture model reflect the signature from complex regional pain syndrome patients"
Wickman JR, Luo X, Jean-Toussaint R, Sahbaie P, Guo TZ, Sacan A, Clark JD, Ajit SK*
Pain Reports 2021 Aug 24;6(3):e950. doi: 10.1097/PR9.0000000000000950. eCollection 2021 Sep-Oct. PMID: 34514274

"Differential RNA packaging into small extracellular vesicles by neurons and astrocytes"
Luo X, Jean-Toussaint R, Sacan A, and Ajit SK*
Cell Communication and Signaling 2021 Jul 10;19(1):75. doi: 10.1186/s12964-021-00757-4. PMID: 34246289

"Uptake of fluorescent labeled small extracellular vesicles in vitro and in spinal cord"
Gupta R, Luo X, Lin Z, Tian Y, Ajit SK*
JoVE J Vis Exp. 2021 May 23;(171). doi: 10.3791/62537. PMID: 34096919

Therapeutic and prophylactic effects of macrophage-derived small extracellular vesicles in the attenuation of inflammatory pain
Jean-Toussaint R, Lin Z, Tian Y, Gupta R, Pande R, Luo Z, Hu H, Sacan A, Ajit SK
Brain Behav Immun. :S0889-1591(21)00047-7. doi: 10.1016/j.bbi.2021.02.005. Online ahead of print. 2021 Feb 16

Xist attenuates acute inflammatory response by female cells
Shenoda BB, Ramanathan S, Gupta R, Tian Y, Jean-Toussaint R, Alexander GM, Addya S, Somarowthu S, Sacan A, Ajit SK
Cell Mol Life Sci., doi: 10.1007/s00018-020-03500-3. [Epub ahead of print], Mar 19, 2020, PMID: 32193609

Proteome characterization of small extracellular vesicles from spared nerve injury model of neuropathic pain
Jean-Toussaint R, Tian Y, Chaudhuri AD, Haughey NJ, Sacan A, Ajit SK
J Proteomics.; 211:103540. doi: 10.1016/j.jprot.2019.103540 [Epub 2019 Oct 24]. Jan 16, 2020, PMID: 31669360

Inflammation potentiates miR-939 expression and packaging into small extracellular vesicles
Ramanathan S, Shenoda BB, Lin Z, Alexander GM, Huppert A, Sacan A, Ajit SK
J Extracell Vesicles.; 8(1):1650595. doi: 10.1080/20013078.2019.1650595. eCollection 2019, Aug 6, 2019, PMID: 31489147

Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange
Ramanathan S, Douglas SR, Alexander GM, Shenoda BB, Barrett JE, Aradillas E, Sacan A, Ajit SK
J Transl Med.; 17(1):81. doi: 10.1186/s12967-019-1833-3, Mar 14, 2019, PMID: 30871575

miR-34a-mediated regulation of XIST in female cells under inflammation
Shenoda BB, Tian Y, Alexander GM, Aradillas-Lopez E, Schwartzman RJ, Ajit SK
J Pain Res.; 11:935-945. doi: 10.2147/JPR.S159458. eCollection 2018, May 8, 2018, PMID: 29773953

Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability
Dou Y, Xia J, Gao R, Gao X, Munoz FM, Wei D, Tian Y, Barrett JE, Ajit S, Meucci O, et al
J Neurosci, 38:887-900, 2018

Complex regional pain syndrome - phenotypic characteristics and potential biomarkers
Birklein F, Ajit SK, Goebel A, Perez RSGM, Sommer C
Nat Rev Neurol.; 14(5):272-284. doi: 10.1038/nrneurol.2018.20. Epub 2018 Mar 16. Review, May 2018, PMID: 29545626

In Vitro Validation of miRNA-Mediated Gene Expression Linked to Drug Metabolism
Shenoda BB, Ramanathan S, Ajit SK
Curr Protoc Pharmacol, 79:9.26.21-29.26.15, 2017

Overview of microRNA Modulation in Analgesic Research
Ramanathan S, Shenoda BB, Ajit SK
Curr Protoc Pharmacol, 79:9.25.21-29.25.10, 2017

Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome
Shenoda BB, Alexander GM, Ajit SK
Journal of Translational Medicine; 14(1):64, 2016, PMID: 26940669

Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells
Shenoda BB, Ajit SK
Clin Med Insights Pathol, 9:1-8, 2016

MicroRNA-Based Biomarkers in Pain
Ramanathan S, Ajit SK
Adv Pharmacol, 75:35-62, 2016

Circulating microRNA Signatures in Rodent Models of Pain
Qureshi RA, Tian Y, McDonald MK, Capasso KE, Douglas SR, Gao R, Orlova IA, Barrett JE, Ajit SK, Sacan A
Mol Neurobiol. [Epub ahead of print] Jun 18, 2015, PMID: 26081151

Regulation of proinflammatory genes by the circulating microRNA hsa-miR-939
McDonald MK, Ramanathan S, Touati A, Zhou Y, Thanawala RU, Alexander GM, Sacan A, Ajit SK
Sci Rep; 6:30976. doi: 10.1038/srep30976, PMID: 27498764, Aug 8, 2016, PMID: 27498764

Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury
Manners MT, Ertel A, Tian Y, Ajit SK
Epigenetics Chromatin; 9:23. doi: 10.1186/s13072-016-0073-5. eCollection 2016, Jun 7, 2016, PMID: 27279901

MicroRNA biology and pain
McDonald MK, Ajit SK
Prog Mol Biol Transl Sci, 131:215-249, 2015

MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
Manners MT, Tian Y, Zhou Z, Ajit SK
FEBS Open Bio; 5:733-40. doi: 10.1016/j.fob.2015.08.010. eCollection 2015, Aug 31, 2015, PMID: 26448907

Analgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome
Douglas SR, Shenoda BB, Qureshi RA, Sacan A, Alexander GM, Perreault M, Barrett JE, Aradillas-Lopez E, Schwartzman RJ, Ajit SK
J Pain; 16(9):814-24. doi: 10.1016/j.jpain.2015.05.008. (Epub Jun 11, 2015 ) Sep 2015, PMID: 26072390

Effect of histone deacetylase inhibitor JNJ-26481585 in pain
Capasso KE, Manners MT, Quershi RA, Tian Y, Gao R, Hu H, Barrett JE, Sacan A, Ajit SK
J Mol Neurosci.; 55(3):570-8. doi: 10.1007/s12031-014-0391-7. (Epub Aug 2, 2014) Mar 2015, PMID: 25085711

Functional significance of macrophage-derived exosomes in inflammation and pain
McDonald MK, Tian Y, Qureshi RA, Gormley M, Ertel A, Gao R, Aradillas Lopez E, Alexander GM, Sacan A, Fortina P, Ajit SK
Pain.; 155(8):1527-39. doi: 10.1016/j.pain.2014.04.029. (Epub Apr 30, 2014) Aug 2014, PMID: 24792623

Purification and microRNA profiling of exosomes derived from blood and culture media
McDonald MK, Capasso KE, Ajit SK
J Vis Exp;  e50294, 2013

Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules
Ajit SK
Sensors (Basel), 12:3359-3369, 2012

Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain
von Schack D, Agostino MJ, Murray BS, Li Y, Reddy PS, Chen J, Choe SE, Strassle BW, Li C, Bates B, et al
PLoS One, 6:e17670, 2011

MicroRNA modulation in complex regional pain syndrome
Orlova IA, Alexander GM, Qureshi RA, Sacan A, Graziano A, Barrett JE, Schwartzman RJ, Ajit SK
J Transl Med.; 9:195. doi: 10.1186/1479-5876-9-195, Nov 10, 2011, PMID: 22074333

Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen
Ajit SK, Pausch MH, Kennedy JD, Kaftan EJ
J Biomed Biotechnol 2010, 2010.

The molecular basis of pain and its clinical implications in rheumatology
Bingham B, Ajit SK, Blake DR, Samad TA
Nat Clin Pract Rheumatol, 5:28-37, 2009

Use of a murine cell line for identification of human nitric oxide synthase inhibitors
Naureckiene S, Edris W, Ajit SK, Katz AH, Sreekumar K, Rogers KE, Kennedy JD, Jones PG
J Pharmacol Toxicol Methods, 55:303-313, 2007

MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability
Crozier RA, Ajit SK, Kaftan EJ, Pausch MH
J Neurosci, 27:4492-4496, 2007

RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling
Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH
Cell Signal, 19:723-730, 2007

Analysis of chimeric RGS proteins in yeast for the functional evaluation of protein domains and their potential use in drug target validation
Ajit SK, Young KH
Cell Signal, 17:817-825, 2005

Yeast-based screening for inhibitors of RGS proteins
Young KH, Wang Y, Bender C, Ajit S, Ramirez F, Gilbert A, Nieuwenhuijsen BW
Methods Enzymol, 389:277-301, 2004

Enhancement of pheromone response by RGS9 and Gbeta5 in yeast
Ajit SK, Young KH
Biochem Biophys Res Commun, 324:686-691, 2004

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The Ajit Lab: Exosome uptake by HUVEC cells.