The España Lab Publications

Selected Articles
Research Articles
Review Articles
Book Chapters

Selected Articles

“Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission”
Alonso IP, O’Connor BM, Bryant KG, Mandalaywala RK, España RA
Addict Neurosci. Sep;3 doi: 10.1016/j.addicn.2022.100029 (2022)

“Intermittent access to oxycodone decreases dopamine uptake in the nucleus accumbens core during abstinence”
Samson KR, Xu W, Kortagere S, España RA
Addict Biol. Nov;27(6):e13241. doi: 10.1111/adb.13241 (2022)

“Chemogenetic Signaling in Space and Time: Considerations for Designing Neuroscience Experiments Using DREADDs”
Clark PJ, Brodnik ZD, España RA
Neuroscientist. Nov 19:10738584221134587. doi: 10.1177/10738584221134587. Online ahead of print (2022)

“Striatal low-threshold spiking interneurons locally gate dopamine”
Holly EN, Davatolhagh MF, España RA, Fuccillo MV
Curr Biol. Sep 27;31(18):4139-4147.e6. Epub (2021)

“Dopamine transporter function fluctuates across sleep/wake state: potential impact for addiction”
Alonso IP, Pino JA, Kortagere S, Torres GE, España RA
Neuropsychopharmacology; Online ahead of print (2021)

“Individual differences in dopamine uptake in the dorsomedial striatum prior to cocaine exposure predict motivation for cocaine in male rats”
Shaw JK, Pamela Alonso I, Lewandowski SI, Scott MO, O'Connor BM, Aggarwal S, De Biasi M, Mortensen OV, España RA
Neuropsychopharmacology; Online ahead of print (2021)

“Study of the release of endogenous amines in Drosophila brain in vivo in response to stimuli linked to aversive olfactory conditioning”
Hidalgo S, Fuenzalida-Uribe N, Molina-Mateo D, Escobar AP, Oliva C, España RA, Andrés ME, Campusano JM
J Neurochem; 156(3):337-351 (2021)

“Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters”
Brodnik ZD, Xu W, Batra A, Lewandowski SI, Ruiz CM, Mortensen OV, Kortagere S, Mahler SV, España RA
J Neurosci; 40(45):8767-8779. doi: 10.1523/JNEUROSCI.0894-20.2020. Epub (2020)

“Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse”
Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, España RA, Aston-Jones G
Journal of Neuroscience; 39(3):503-518] (2020)

“Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress”
Brodnik ZD, Black EM, España RA
Neuropsychopharmacology; 2020 Feb;45(3):472-481 (2020)

"Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine"
Bernstein DL, Badve PS, Barson JR, Bass CE, España RA
Addict Biol., doi: 10.1111/adb.12553. Sep;23(5):1032-1045 (2018)

"Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine"
Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA
Addict Biol; 22(6):1695-1705 (2017)

"Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine"
Brodnik ZD, Black EM, Clark MJ, Kornsey KN, Snyder NW, España RA
Neuropharmacology; 125:295-307. doi: 10.1016/j.neuropharm.2017.07.032. (Epub Aug 1, 2017) Oct 2017

"Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling"
Levy KA, Brodnik ZD, Shaw JK, Perrey DA, Zhang Y, España RA
Psychopharmacology (Berl).;234(18):2761-2776. doi: 10.1007/s00213-017-4673-y (Epub Jun 30, 2017) Sep 2017

"Dopamine transporters govern diurnal variation in extracellular dopamine tone"
Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR
Proceedings of the National Academy of Sciences; 111(26):E2751-9 (2014)

"Demon voltammetry and analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures"
Yorgason, JT, España, RA, Jones SR
Journal of Neuroscience Methods; 2:158-164 (2011)

“The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system”
España RA, Oleson E, Locke JL, Roberts DCS, Jones SR
Eur J Neurosci. 2010 Jan;31(2):336-48. doi: 10.1111/j.1460-9568.2009.07065.x. Epub 2009 Dec 23 (2010)

Research Articles

“Striatal low-threshold spiking interneurons locally gate dopamine”
Holly EN, Davatolhagh MF, España RA, Fuccillo MV
Curr Biol. Sep 27;31(18):4139-4147.e6. Epub (2021)

“Spinal Dopaminergic Mechanisms Regulating the Micturition Reflex in Male Rats with Complete Spinal Cord Injury”
Qiao Y, Brodnik ZD, Zhao S, Trueblood CT, Li Z, Tom VJ, España RA, Hou S
J Neurotrauma. Mar 15;38(6):803-817, (2021)

“Pharmacological Characterization of 4-Methylthioamphetamine Derivatives”
Guajardo FG, Velásquez VB, Raby D, Núñez-Vivanco G, Iturriaga-Vásquez P, España RA, Reyes-Parada M, Sotomayor-Zárate R
Molecules; 25(22) (2020)

“Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system”
Cid-Jofré V, Gárate-Pérez M, Clark PJ, Valero-Jara V, España RA, Sotomayor-Zárate R, Cruz G, Renard GM
Neuropharmacology; 183:108404 (2020)

“Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention”
Marshall CA, Brodnik ZD, Mortensen OV, Reith MEA, Shumsky JS, Waterhouse BD, España RA, Kortagere S
Neuropharmacology; 148:178–188 (2019)

“Local GABAA Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens”
Brodnik ZD, Batra A, Oleson EB, España RA
ACS Chemical Neuroscience; 10(4):1978-1985 (2019)

“The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory”
Zhang YX, Akumuo RC, España RA, Yan CX, Gao WJ, Li YC
Neuropharmacology; 141:113-125 (2018)

“Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease”
Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Panzer KV, Lim J, Duda JE, España RA, Cullen DK
J Tissue Eng Regen Med; 12(7):1702-1716 (2018)

"Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine"
Gentile TA, Simmons SJ, Barker DJ, Shaw JK, España RA, Muschamp JW
Addict Biol.;23(1):247-255. doi: 10.1111/adb.12507 (Epub Apr 17, 2017) Jan 2018

"Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens"
Schelp SA, Brodnik ZD, Rakowski DR, Pultorak KJ, Sambells AT, España RA, Oleson EB
J Pharmacol Exp Ther; 364(1):145-155. doi:10.1124/jpet.117.241802. (Epub Oct 20, 2017) Jan 2018

"Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine"
Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA
Addict Biol; 22(6):1695-1705 (2017)

"L-Tyrosine availability affects basal and stimulated catecholamine indices in prefrontal cortex and striatum of the rat"
Brodnik ZD, Double M, España RA, Jaskiw GE
Neuropharmacology; 123:159-174. doi:10.1016/j.neuropharm.2017.05.030 (Epub May 29, 2017) Sep 1, 2017

"Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats"
Escobar AP, González MP, Meza RC, Noches V, Henny P, Gysling K, España RA, Fuentealba JA, Andrés ME
Int J Neuropsychopharmacol.; 20(8):660-669. doi:10.1093/ijnp/pyx042 (Aug 1, 2017)

"Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments"
MacLaren DA, Browne RW, Shaw JK, Krishnan Radhakrishnan S, Khare P, España RA, Clark SD
eNeuro; 3(5). pii: ENEURO.0219-16 (2016)

"Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition"
Brodnik ZD, Ferris MJ, Jones SR, España RA
ACS Chem Neurosci; 15;8(2):281-289 (2016)

"The GLP-1 agonist exendin-4 attenuates self-administration of sweetened fat on fixed and progressive ratio schedules of reinforcement in rats"
Bernosky-Smith KA, Stanger DB, Trujillo AJ, Mitchell LR, España RA, Bass CE
Pharmacol Biochem Behav; 142:48-55 (2016)

"Dopamine uptake dynamics are preserved under isoflurane anesthesia"
Brodnik ZD, España RA
Neurosci Lett; 606:129-134 (2015)

"Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function"
Escobar AP, Cornejo FA, Olivares-Costa M, González M, Fuentealba JA, Gysling K, España RA, Andrés ME
J Neurochem; 134:1081-90 (2015)

"Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep"
Brodnik ZD, Bernstein DL, Prince CD, España RA
Behav Brain Res; 291:377-84 (2015)

"Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1"
Prince CD, Rau AR, Yorgason JT, España RA
ACS Chemical Neuroscience; 291:377-84 (2015)

"Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling"
Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ
Eur J Neurosci; 40(1):2255-63 (2014)

"Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals"
Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR
Eur J Neurosci; 37(6):1022-31 (2013)

"Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats"
Yorgason JT, España RA, Konstantopoulos JK, Weiner JL, Jones SR
Eur J Neurosci; 38(4):2628-36 (2013)

"Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward"
Oleson EB, Ferris MJ, España RA, Harp J, Jones SR
Eur J Pharmacol; 2683(1-3):161-5 (2012)

"Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection"
Yorgason, JT, Jones SR, España RA
Neuroscience; 182:125-32 (2011)

"Demon voltammetry and analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures"
Yorgason JT, España RA, Jones SR
Journal of Neuroscience Methods; 2:158-164 (2011)

"Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration"
España RA, Melchior JR, Roberts DCS, Jones SR
Psychopharmacology; 214(2):415-426 (2011)

"Hypocretin/Orexin regulates cocaine self-administration via actions on the mesolimbic dopamine system"
España, RA, Oleson, E, Locke, JL Roberts, DCS, Jones, SR
European Journal of Neuroscience; 31:336-348 (2010)

"Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717"
Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA
Psychopharmacology; 202(1-3):355-69 (2009)

"Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala"
Stalnaker TA, España RA, Berridge CW
Synapse; 63(1):82-5 (2009)

"Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery"
España RA, Roberts DCS, Jones SR
Neuroscience; 155:250-257 (2008)

"Running promotes wakefulness and increases cataplexy in orexin knockout mice"
España RA, McCormack SL, Mochizuki T, Scammell TE
Sleep; 30(11):1417-25 (2007)

"Organization of noradrenergic efferents to arousal-related basal forebrain structures"
España RA, Berridge CW
Journal of Comparative Neurology; 496 (5):668-683 (2006)

"Afferents to the orexin neurons of the rat brain"
Yoshida K, McCormack S, España RA, Crocker A, Scammell TE
J Comp Neurol; 494(5):845-61 (2006)

"Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures"
España RA, Reis KM, Valentino RJ, Berridge CW
J Comp Neurol; 481 (2):160-178 (2005)

"Concomitant loss of dynorphin, NARP, and orexin in narcolepsy"
Crocker A, España RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE
Neurology; 65(8):1184-8 (2005)

"Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice"
España RA, Berridge CW, Gammie SC
Peptides; 25(11):1927-34 (2004)

"Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration"
España RA, Valentino RJ, Berridge CW
Neuroscience; 121(1):201-1 (2003)

"Additive wake-promoting actions of medial basal forebrain noradrenergic alpha1- and beta-receptor stimulation"
Berridge CW, Isaac SO, España RA
Behav Neurosci; 117(2):350-9 (2003)

"Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures"
Lin SH, Arai AC, España RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O
Neuroscience; 114(1):229-38 (2002)

"Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin"
España RA, Plahn S, Berridge CW
Brain Res; 943(2):224-36 (2002)

"Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action"
España RA, Baldo BA, Kelley AE, Berridge CW
Neuroscience; 106(4):699-715 (2001)

"Synergistic sedative effects of noradrenergic alpha(1)- and beta-receptor blockade on forebrain electroencephalographic and behavioral indices"
Berridge CW, España RA
Neuroscience; 99(3):495-505 (2000)

Review Articles

“Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria”
Gordián-Vélez WJ, Chouhan D, España RA, Chen HI, Burdick JA, Duda JE, Cullen DK
Brain Res Bull. Oct;175:168-185. Epub (2021)

“Hypocretin receptor 1 involvement in cocaine-associated behavior: Therapeutic potential and novel mechanistic insights”
Brodnik ZD, Alonso IP, Xu W, Zhang Y, Kortagere S, España RA
Brain Res; 15;1731:145894 (2020)

"Norepinephrine at the nexus of arousal, motivation and relapse"
España RA, Schmeichel BE, Berridge CW
Brain Res; 1641(Pt B):207-16. doi:10.1016/j.brainres.2016.01.002 (Epub Jan 7, 2016) Review, Jun 15, 2016

"Presynaptic dopamine modulation by stimulant self-administration"
Espana RA, Jones SR
Front Biosci; 5:261-76 (2013)

"Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms"
Calipari ES, España RA
Front Behav Neurosci; 6:54 (2012)

"Hypocretin/orexin involvement in reward and reinforcement"
España RA
Vitam Horm; 89:185-208 (2012)

"Noradrenergic modulation of wakefulness/arousal"
Berridge CW, Schmeichel BE, España RA
Sleep Med Rev; 16(2):187-97 (2012)

"Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks Conference"
McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S
Behav Brain Res; 225(1):348-57 (2011)

"Sleep neurobiology from a clinical perspective"
España RA, Scammell TE
Sleep; 34(7):845-58 (2011)

"Hypocretin/orexin in arousal and stress"
Berridge CW, España RA, Vittoz NM
Brain Research; 1314:91-102 (2010)

“A Neurochemical Perspective on Dopamine Interactions with Psychostimulants”
España RA, Jones SR
In: The nucleus accumbens: neurotransmitters and related behaviors, (Hélène N David, Ed) Kerala, Research Signpost, 329-368 (2008)

“Sleep neurobiology for the clinician”
España RA, Scammell TE
Sleep, 27(4):811-20 (2004)

Book Chapters

“Neurochemistry of Sleep”
Alonso, IP, España RA
In: The encyclopedia of sleep (Clete A Kushida, Ed) San Diego, Elsevier (2021)

“Hypocretin receptor 1 regulation of dopamine neurotransmission and motivated behavior”
Shaw JK, Black EM, Perrey DA, Zhang Y, España RA.
In: Functions of Orexins/Hypocretins, (J. Fadel, J. A., Burk, Eds.), San Diego, Elsevier; (2019)

"Neurochemistry of Sleep"
España RA
In: The encyclopedia of sleep (Clete A Kushida, Ed) San Diego, Elsevier (2013)

"A Neurochemical Perspective on Dopamine Interactions with Psychostimulants"
España RA, Jones SR
In: The nucleus accumbens: neurotransmitters and related behaviors, (Hélène N David, Ed) Kerala, Research Signpost, 329-368 (2008)

Hypocretin/orexin in stress and arousal"
Berridge CW, España RA
In: Hypocretins as integrators of physiological signals, (L de Lecea and J G Sutcliffe, Eds) New York, Kluwer Academic/Plenum Publishers (2005)

"Stress and coping: lateralization of dopamine systems projecting to the prefrontal cortex"
In: The asymmetrical brain, (K. Hugdahl, R.J. Davidson, Eds.) Berridge, CW, España, RA, and Stalnaker, TA Cambridge, MIT Press, 69-103 (2003)