For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

Andréia C.K. Mortensen

Andréia C.K. Mortensen, PhD

Assistant Professor

Department: Pharmacology & Physiology


  • PhD in Biochemistry - Ribeirão Preto School of Medicine, University of São Paulo, Brazil (2001)

Awards & Honors

  • Society for Neuroscience poster selected as a Neuroscience “Hot Topic” (2016)
  • International Brain Research Organization (IBRO) award to attend III Latin American School of Neuroscience (1998)

Postgraduate Training / Additional Certifications

  • Postdoctoral Fellowship in Neuroscience – Vollum Institute, Oregon Health and Sciences University
  • Postdoctoral Associate in Neurobiology- University of Pittsburgh

Dr. Mortensen is an assistant professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine.

Research Overview

Our lab is interested in further the knowledge of mechanisms for regulation of glutamate transporters. We are highly interested in the identification and development of allosteric compounds that enhance their activity. Our goal is to target glutamate transporter subtype EAAT2 (the main glutamate transporter in the brain), for the development of approaches and compounds for neuroprotection in neurological disorders.

Visit the A. Mortensen Lab.

Research Interests

Glutamate transporters, neurological disorders and positive allosteric modulators that target transporters


Excitatory amino acid transporters (EAATs) present on the plasma membrane regulate and modulate glutamate neurotransmission by removing synaptically released glutamate back into cells, thereby having a profound impact on the level of receptor activation.

The main goals of my research are to investigate the role of EAAT2, the main CNS astrocytic carrier, in neurodegenerative disorders including traumatic brain injury (TBI), ischemia, stroke, epilepsy and HIV-associated neurocognitive disorder (HAND), among others.

Molecules that limit glutamate release, antagonists of ionotropic glutamate receptors and compounds that target calcium influx have been demonstrated to reduce secondary effects of brain trauma. However, severe side effects limit their clinical use. In addition, compounds that enhance EAAT2 activity in pathological conditions, such as ß-lactam antibiotics, attenuate damage in both acute and chronic neurodegenerative disorders. However, this approach is best administered prophylactically and could be associated with non-specific effects that limit their utility

Spider venoms are a valuable source of compounds bioactive on synaptic transmission. We have discovered a unique natural compound from the spider Parawixia bistriata that increases the activity of glutamate transporter EAAT2 and has neuroprotective effect on retinal tissue from ischemic damage.

We have identified structural components that interact with this compound by using chimeras of EAAT2 and other subtypes of glutamate transporters. This unique information was used in virtual screening approaches to identify positive allosteric modulators of EAAT2. These novel compounds are being characterized in in vitro models of excitotoxicity and brain injury.

Our long-term goal is to progress our preclinical studies with this class of PAMs of EAAT2, by evaluating translational possibilities in in vivo models of neurological disorders, such as brain injury and epilepsy, and begin clinical trials in patients of relevant neurological disorders.


Selected Publications

"Novel positive allosteric modulators of glutamate transport have in vitro neuroprotective properties in an in vitro excitotoxic model"
Falcucci RM, Wertz R, Green J, Salvino JM, Meucci O, Fontana AC
ACS Chem Neurosci.. doi: 10.1021/acschemneuro.9b00061. [Epub ahead of print]. PMID: 31257852, Jul 1, 2019

"Identification of a Novel Allosteric Modulator of the Human Dopamine Transporter"
Aggarwal S, Liu X, Rice C, Menell P, Clark PJ, Paparoidamis N, Xiao YC, Salvino JM, Fontana ACK, España RA, Kortagere S, Mortensen OV
ACS Chem Neurosci. doi: 10.1021/acschemneuro.9b00262. [Epub ahead of print]. PMID: 31184115, Jun 24, 2019

"Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures"
Primini, EO, Liberato, JL, Fontana, ACK & Santos, WF
Journal of Venomous Animals and Toxins Including Tropical Diseases, 25, e148818, 2019

"Caffeic Acid Phenethyl Ester (CAPE) Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity by Activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt Signaling Pathways"
Ferreira RS, Dos Santos NAG, Bernardes CP, Sisti FM, Amaral L, Fontana ACK, Dos Santos AC
Neurotox Res. doi: 10.1007/s12640-019-00042-w. PubMed PMID: 31016689, Apr 23, 2019

"Parawixin2 Protects Hippocampal Cells in Experimental Temporal Lobe Epilepsy"
Liberato JL, Godoy LD, Cunha AOS, Mortari MR, de Oliveira Beleboni R, Fontana ACK, Lopes NP, Dos Santos WF
Toxins (Basel), 10(12). pii: E486. doi: 10.3390/toxins10120486, Nov 22, 2018 

"Protocols for Measuring Glutamate Uptake: Dose-Response and Kinetic Assays in In Vitro and Ex Vivo Systems"
Fontana ACK
Curr Protoc Pharmacol.;82(1):e45. doi: 10.1002/cpph.45. Epub 2018 Aug 27. PMID: 30152172, Sep 2018

"Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2"
Kortagere S, Mortensen OV, Xia J, Lester W, Fang Y, Srikanth Y, Salvino JM, Fontana ACK
ACS Chem Neurosci.;9(3):522-534. doi: 10.1021/acschemneuro.7b00308. Epub 2017 Nov 30.PMID: 29140675, Mar 21, 2018

"Drugs to alter extracellular concentration of glutamate: modulators of glutamate uptake systems"
Fontana, AC
Book: Biochemical Approaches for Glutamatergic Neurotransmission, ed. S. Parrot, Denoroy, Luc: Humana Press. ISBN: 978-1-4939-7228-9, doi: 10.1007/978-1-4939-7228-9, 2017

"Isolation and chemical characterization of agelaiatoxin8 (AvTx8) from Agelaia vicina wasp venom and its biological effects on GABA neurotransmission"
Pizzo AB, Beleboni RO, Gomes Carolino RO, de Oliveira L, Miranda A, Coutinho-Netto J, Fontana ACK, Dos Santos WF.
J Biochem Mol Toxicol. doi: 10.1002/jbt.21941, Jun 16, 2017

"Current approaches to enhance glutamate transporter function and expression"
Fontana AC
J Neurochem. doi: 10.1111/jnc.13200, Jun 20, 2015

"Neuroprotective effects of the glutamate transporter activator, MS-153, following traumatic brain injury in the adult rat"
Fontana AC, Fox DP, Zoubroulis A, Mortensen OV, Raghupathi R
J Neurotrauma, Jul 22, 2015

"Molecular determinants of transport stimulation of EAAT2 are located at interface between the trimerization and substrate transport domains"
Mortensen OV, Liberato JL, Coutinho-Netto J, Dos Santos WF, Fontana AC
J Neurochem; 133(2):199-210. doi: 10.1111/jnc.13047 (Epub 2015 Feb 26) PubMed PMID: 25626691, April 2015

"The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities"
Timple JM, Magalhães LG, Souza Rezende KC, Pereira AC, Cunha WR, Andrade e Silva ML, Mortensen OV, Fontana AC
J Nat Prod.; 76(10):1889-95. doi: 10.1021/np400452n. (Epub 2013 Oct 10) Oct 25, 2013

"Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action"
Kortagere S, Fontana AC, Rose DR, Mortensen OV
Neuropharmacology, 72:282-290. doi: 10.1016/j.neuropharm.2013.04.026, Sept 2013

"A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants"
Larsen MB, Fontana AC, Magallhães LG, Rodrigues V, Mortensen OV
Mol Biochem Parasitol. Jan 18, 2011

"Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin"
Fontana AC, Sonders MS, Pereira-Junior OS, Knight M, Javitch JA, Rodrigues V, Amara SG, Mortensen OV
Eur J Pharmacol;616(1-3):48-57, Aug 15, 2009

"Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom"
Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG.
Mol Pharmacol. 2007 Nov;72(5):1228-37. Epub Jul 23, 2007

"Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake"
Fontana AC, Guizzo R, de Oliveira Beleboni R, Meirelles E Silva AR, Coimbra NC, Amara SG, dos Santos WF, Coutinho-Netto
J. Br J Pharmacol;139(7):1297-309, Aug 2003

"Excitatory amino acid transporters: keeping up with glutamate"
Amara SG, Fontana AC
Neurochem Int;41(5):313-8. Review, Nov 2002

Contact Information

Department of Pharmacology & Physiology
245 N. 15th Street
Mail Stop 488
Philadelphia, PA 19102
Phone: 215.762.4399
Fax: 215.762.2299