Why Are Thromboembolic Events More Common in Women With Atrial Fibrillation Than in Men?
Krista Vadaketh
Women with atrial fibrillation not only have an increased risk of stroke compared to men, but also experience more severe and disabling strokes. Factors that predispose women with atrial fibrillation to developing more thromboembolic events than their male counterparts include the pathophysiology of the condition (larger left atrial volumes, reduced atrial contractility, non-pulmonary vein triggers, increased parasympathetic responses, higher degree of fibrotic remodeling), modifiable and non-modifiable risk factors (e.g., hyperthyroidism, suboptimal blood pressure management), and differences in clinical presentation (atypical symptoms, such as weakness and fatigue are also more common in women) that may delay diagnosis and treatment.
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