“Timeless prevents senescence-associated phenotypes and enhances DNA repair to promote esophageal cancer cell growth”
Noguchi C, Horne KI, Brewster T, Duffy A, Shah JP, Theriault A, El Naggar O, Vavilala S, Sheth S, Noguchi E*
Exp Cell Res, 455(1):114828 (2025)

“The p53 DNA damage response and Fanconi anemia DNA repair pathway protect against acetaldehyde-induced replication stress in esophageal keratinocytes”
Peake JD, Horne KI, Noguchi C, Gilligan JP, Noguchi E*
Cell Cycle, 22(18): 2088-2096 (2023)

“Fanconi anemia: Current insights regarding epidemiology, Cancer and DNA repair”
Peake JD, Noguchi E*
Human Genetics, 141(12): 1811-1836 (2022)

"The methyltransferase enzymes KMT2D, SETD1B, and ASH1L, are key mediators of both metabolic and epigenetic changes during cellular senescence"
Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Johnson FB, Brown-Borg H, Noguchi E, Sell C
Mol. Biol. Cell, 33(5):ar36 (2022)

"Alcohol metabolism enriches squamous cell carcinoma cancer stem cells that survive oxidative stress via autophagy"
Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl A, Nakagawa H
Biomolecules, 11(10): 1479 (2021)

“FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes”
Peake JD, Noguchi C, Lin B, Theriault A, O'Connor M, Sheth S, Tanaka K, Nakagawa H, Noguchi E*
Mol Oncol. 15(11): 3109-3124 (2021)

“Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan”
Noguchi C, Wang L, Shetty M, Mell JC, Sell C, Noguchi E*
Cell Cycle, 20(3):247-255 (2021)

“Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes”
Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klei-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H
PLoS ONE, 15 (9):e0239625 (2020)

“Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe”
Anandrajan V, Noguchi C, Oleksak J, Grothusen G, Terlecky D, Noguchi E*
Current Genetics, 66(3): 593-605 (2020)

"Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan"
Shetty M, Noguchi C, Wilson S, Martinez E, Shiozaki K, Sell C, Mell JC, Noguchi E*
Aging Cell, 19(2): e13068 (2020)

"The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning"
Noguchi C, Singh T, Ziegler MA, Peake JD, Khair L, Aza A, Nakamura TM, Noguchi E*
Epigenetics & Chromatin, 12(1):24 (2019)

Books: DNA Replication Controls Volumes 1 and 2
Noguchi E (Editor)
Genes (Basel), MDPI (2016-2017)

"Regulation of DNA replication through natural impediments in the eukaryotic genome”
Gadaleta MC, Noguchi E*
Genes (Basel), 8(3):98 (2017)

"Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast"
Noguchi C, Grothusen G, Anandarajan V, Martínez-Lage García M, Terlecky D, Corzo K, Tanaka K, Nakagawa H, Noguchi E*
Cell Cycle, 16(1): 45-58 (2017)

"Timeless protection of telomeres"
Gadaleta MC, González-Medina A, Noguchi E*
Curr Genet, 62(4): 725-730 (2016)

"ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds"
Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinivasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H
Am J Cancer Res, 6(4): 781-796 (2016)

"Swi1/Timeless prevents repeat instability at fission yeast telomeres"
Gadaleta MC, Das MM, Tanizawa H, Chang Y, Noma K, Nakamura TM, Noguchi E*
PLOS Genetics, 12 (3): e1005943. doi:10.1371/journal.pgen.1005943 (2016)

 
Contact Us

The Noguchi Lab
Drexel University College of Medicine Department of Biochemistry & Molecular Biology
245 North 15th Street, MS 497, NCB 11319, Philadelphia, PA 19102

Eishi Noguchi, PhD
Principal Investigator
   267.359.2662 |   en34@drexel.edu

 
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