For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

Alessandro Fatatis Laboratory Publications

Selected Publications

"Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells"
Shen F, Zhang Y, Jernigan DL, Yan J2, Garcia FU2, Meucci O1, Salvino JM, and Fatatis A
Molecular Cancer Research (accepted for publication)

"A pre-clinical model of inflammatory breast cancer to study the involvement of CXCR4 and ACKR3 in the metastatic process"
Wurth R., Tarn K., Jernigan D.L., Fernandez S.V., Cristofanilli M., Fatatis A., and Meucci O.
Translational Oncology 8, 358-367 (2015)

"Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem Cell Properties in Prostate Cancer Cells"
Talati PG, Gu L, Ellsworth EM, Girondo M, Trerotola M, Hoang DT, Leiby B, Dagvadorj A, McCue PA, Lallas CD, Trabulsi EJ, Gomella L, Aplin A, Languino L, Fatatis A, Rui H and Nevalainen MT
American J. Pathology 185, 2505-2522 (2015)

"CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines"
Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Andò S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP and Pestell RG
Cancer Research 74(23):7103-14 (December 1, 2014)

"Metabolic stress control of cytoskeletal dynamics and metastasis"
Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O’Connell M, Jernigan DL, Fatatis A, Languino LR, Bosari S and Altieri DC
Journal of Clinical Investigation 123, 2907-2920 (2013)

"Interleukin-1β promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine feature"
Liu Q, Russell MR, Shahriari K, Jernigan D, Lioni MI, Garcia FU and Fatatis A
Cancer Research 73, 3297-3305 (2013)

"Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes"
Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY and Knudsen KE
Journal of Clinical Investigation 123, 493-508 (2013)

"Trop-2 promotes cancer metastasis by modulating β1 integrin functions"
Trerotola M, Jernigan DL, Liu Q, Siddiqui J, Fatatis A and Lucia Languino LR
Cancer Research 73, 3155-3167 (2013)

"The chemokine receptor CX3CR1 is directly involved in the arrest of breast cancer cells to the skeleton"
Jamieson WL, Zhang Y, Fong AM, Meucci O and Fatatis A
Breast Cancer Research 13, R91 (2011)

"Targeting the alpha receptor for Platelet-Derived Growth Factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis"
Russell MR, Liu Q and Fatatis A
Clinical Cancer Research 16, 5002-5010 (2010)

"The alpha receptor for Platelet Derived Growth Factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms"
Russell MR, Liu Q, Lei H, Kazlauskas A and Fatatis A
Cancer Research 70, 4195-4203 (2010)

"Osteoblasts modulate Ca2+ signaling in bone-metastatic prostate and breast cancer cells"
D'Ambrosio J and Fatatis A
Clin. Exp. Metastasis 26, 955-964 (2009)

"Antibody-mediated blockade of Platelet Derived Growth Factor Receptor inhibits early prostate skeletal metastases"
Russell MR, Jamieson WL, Dolloff NG and Fatatis A
Oncogene 28: 412-421 (2009)

"The CX3CR1 receptor is expressed by the prostate gland as its chemokine ligand fractalkine is detected in bone marrow and cleaved by an androgen-dependent mechanism: potential role in skeletal metastasis from prostate adenocarcinoma"
Jamieson WL, Shimizu S, D’Ambrosio JA, Meucci O and Fatatis A
Cancer Research 68, 1715-1722 (2008)

"Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha Platelet-derived Growth factor receptor"
Dolloff NG, Russell MR, Loizos N and Fatatis A
Cancer Research 67, 555-562 (2007)

"Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha Platelet Derived Growth Factor Receptor"
Dolloff NG, Shulby SS, Nelson AV, Stearns ME, Johannes GJ, Thomas JD, Meucci O and Fatatis A
Oncogene 24: 6848-54 (2005)

"CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration and survival of human prostate cancer cells"
Shulby SA, Dolloff NG, Stearns ME, Meucci O and Fatatis A
Cancer Research 64:4693-4698 (2004)

 Back to Top

Bone invasion image from the Alessandro Fatatis Research Laboratory.