Center for Genomic Sciences (CGS)
The Center for Genomic Sciences is a comprehensive and flexible research facility designed to investigate a broad range of medically and surgically relevant problems using cutting-edge molecular genetics, genomics and bioinformatics techniques. The Center for Genomic Sciences, located at 245 N. 15th Street in Philadelphia, is a self-contained research unit of the College of Medicine's Institute for Molecular Medicine and Infectious Disease.
The Center for Genomic Sciences is broadly focused on understanding the function and evolution of genomes. We use comparative and functional approaches, taking advantage of resources available through the Genomics Core Facility and Center for Advanced Microbial Processing. We are particularly focused on microbial genomes (both prokaryotic and eukaryotic), from the smallest cellular genomes, like Borrelia burgdorferi (the causative agent of Lyme disease) with a single ~1 megabase chromosome, to some of the largest known, like the dinoflagellate Procentrum lima whose genome exceeds 100 gigabases (much larger than the 3 gigabase human genome).
One of our major model systems is the human chronic pathogen Haemophilus influenzae, for which we are obtaining complete sequences of ~1000 clinical strains isolated from both healthy and diseased patients from a variety of body sites and using novel bioinformatics approaches to understanding its population-level genomics. Similar comparative projects are being carried out within other species, including Gardnerella vaginalis, Lactobacillus crispatus, Streptococcus pneumoniae, Moraxella cattarhalis, Burkholderia cenocenocepacia and Acinetobacter baumanii. The goal of this research is to understand the evolution of pathogenesis, particularly in the context of chronic infection, and to isolate virulence determinants by applying phylogenomics and statistical genetics approaches.
Sequencing, Gene Expression and Genotyping Services
The Center for Genomic Sciences provides a collaborative interdisciplinary environment for scientists, engineers and clinicians performing basic, translational, industrial and clinical research programs covering a wide range of programs in both prokaryotic and eukaryotic genomics, including host-pathogen interactions. Center for Genomic Sciences technologies include multiple cutting platforms for whole genome sequencing, genotyping and expression analyses. In addition to standard Illumina sequencing we also have the Pacific Biosciences third generation DNA sequencing technology. Similarly for expression analyses in addition to RNA seq we have other types of nucleic acid counting platforms, including both the nanoString technology and the Bio-Rad droplet digital PCR system.
Bioinformatics Services
Bioinformatics is an interdisciplinary science that seamlessly integrates computational methodologies into molecular biology, biological databases and genotypes. It focuses on the molecular biology and physics of the cell and emphasizes the use of advanced mathematics and computation. CGS is not only a consumer of bioinformatic analysis programs, but a major developer as well, particularly in the realm of comparative bacterial genomics where we have played a leadership role for a decade.
Upcoming and Past Events
ILADS and PA Lyme Resource Network Scientific Meeting
June 7-8, 2025: The Complexity of Lyme: Diagnosing and Treating Tick-Borne and Related Diseases, being held in the Geary Auditoriums of DUCoM’s New College Building – Ken Liegner, MD Keynote Speaker. Learn more.
3rd Mark Shirtliff Memorial Biofilm Meeting
June 13, 2025: The “3rd Mark Shirtliff Memorial Biofilm Meeting” being held in the Geary Auditoriums of DUCoM’s New College Building: Steve Goodman, PhD Keynote Speaker, The Ohio State University. Learn more.
23rd International Symposium on Recent Advances in Otitis Media
June 15-18, 2025: The “23rd International Symposium on Recent Advances in Otitis Media” being held at CHOP with Susan Emmett, MD MPH, Keynote Speaker. Learn more.
Contact Us
Center for Genomic Sciences
Drexel University College of Medicine
245 N. 15th Street, Floor 17, New College Building
Philadelphia, PA 19102
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News and Announcements
RFK Jr.'s insistence that the government ignores chronic disease is misguided
Garth Ehrlich, PhD, a professor in the College of Medicine, was quoted in a February 1, 2025 NBC News article debunking claims that the federal government prioritizes funding research in infectious diseases more than it does for chronic diseases. The article was also published by yahoo! News. Read more.
LymeX Diagnostics Phase 3 Prize Awarded
With an estimated 476,000 cases in America annually, the U.S. has an urgent need for new Lyme Disease diagnostics. That’s why Drexel University is thrilled to be a Phase 3 winner in the Steven & Alexandra Cohen Foundation’s $10+ million LymeX Diagnostics Prize. Through Phase 3, the Drexel University College of Medicine team led by MaryAnn Comunale, had access to webinar modules, mentorship, and networking opportunities as we planned a clinical performance study to validate our proposed solution. Industry supporters Labcorp and Quest Diagnostics provided non-financial in-kind support, helping our team deepen our understanding of the diagnostics industry, how clinical laboratories operate, and how to work with commercial laboratories. Learn more.
Drexel University and Thomas Jefferson University are longtime allies in the fight against cancer. That partnership was formalized in 2013 as the Sidney Kimmel Comprehensive Cancer Center Research Consortium, a relationship that was reinvigorated in 2021, in preparation for the center’s application to be named a National Cancer Institute-designated comprehensive cancer center. Read more. (Pulse Spring 2024)
Alumni News
Congratulations to MS in Biomedicine and Business alumna Hilary Schultz, for being featured in the Top 100 Innovators & Entrepreneurs magazine as their cover story.
An educational game designed by a team from the Institute for Molecular Medicine and Infectious Disease at Drexel University College of Medicine recently took home a silver medal from the International Serious Play Awards competition in Toronto, Canada. Read more.
ILADEF Neil Spector Award
The International Lyme and Associated Diseases Society presented the Neil Spector Award to PhD candidate Ben Haslund-Gourley at the 2023 ILADS scientific conference. This award is given to the best scientific presentation of the conference. Ben presented two talks: Immunoglobulin N-Glycans Role in Diagnosing Lyme Disease and Immunoglobulins N-glycans Impair Host Response to Lyme Disease. Ben’s win is the second consecutive win for a Drexel Microbiology & Immunology program. Graduate student Kayla Socarras was awarded the honor in 2022. Prior to the past two years, awardees have been senior investigators with international reputations. Ben is mentored by Dr. Mary Ann Comunale in the Department of Microbiology & Immunology.
VOA Burmese Profile
Michiko Thwe, biomedical engineering PhD candidate, was interviewed about their research in Alzheimer's Disease by VOA Burmese. Watch video on YouTube at https://www.youtube.com/watch?v=PhmS3HYFoCE&t=14s (အယ်လ်ဇိုင်းမားရောဂါ သုသေသနပြုစုနေသူ).
Van Duuren Fulbright Travel Grant
Keziah Adjei, Molecular Medicine program student, was awarded a Van Duuren Fulbright travel grant to attend America Society of Tropical Medicine and Hygiene (ASTMH) conference in Chicago from October 18 to 22, 2023. Adjei was one of only four recipients this year of this award which provides funds for travel‐related educational expenses to select Fulbrighters studying in the fields of sciences and public health. The America Society of Tropical Medicine and Hygiene (ASTMH), draws tropical medicine and global health professionals representing academia, foundations, government, not-for-profit organizations, non-governmental organizations, the private sector, the military and private practice. The meeting is designed for researchers, professors, government and public health officials, military personnel, travel clinic physicians, practicing physicians in tropical medicine, students and all health care providers working in the fields of tropical medicine, hygiene and global health.
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