April 19, 2019
Do you have a psychiatric patient with tremors, ataxia, or fasciculations? Think Lithium!
Clinical findings include:
GI symptoms (nausea/vomiting)
EKG changes (including prolonged QTc)
Neurologic changes from subtle symptoms like sluggishness or confusion to seizures and encephalopathy (late signs!)
When in doubt - check a level
Therapeutic level: 0.8 - 1.2 mEq/L
Toxicity:
Mild 1.5 - 2.5 mEq/L
Moderate 2.5 - 3.5 mEq/L
Severe > 3.5 mEq/L
Treatment
ABCs and supportive care
Benzos for seizure
Hydration with Normal Saline to increase Li clearance
Follow the sodium, as Li can cause diabetes insipidus and hypernatremia
Gi Decontamination
No role for charcoal!
In acute ingestion, whole bowel irrigation
Indications for hemodialysis:
Serum concentration > 5 mEq/L
Serum concentration > 4 mEq/L with impaired renal clearance
Decreased level of consciousness or seizures
Symptomatic patients with concentration > 2.5 mEq/L, as well as impaired renal clearance or unable to received IV fluids
References: https://www.uptodate.com/contents/lithium-poisoning