Research
Our major disease focus has been on cancer. Cancer is a multifaceted disease and basic biochemical/molecular research on a broad range of cellular processes has been extremely powerful in understanding cancer biology—from transformation, to metastasis, to response, to treatment. Cancer biology is a "big tent" under which many disparate areas of inquiry can be united and focused.
Related Laboratories and Research Groups
Cancer biology research program
- Control of cell proliferation (Noguchi, Reginato)
- Signal transduction (Noguchi, Reginato)
- DNA replication and repair (Berkowitz, Noguchi)
- Cancer metabolism (Reginato)
- Metastasis (Reginato)
- Computational biology (Somarowthu)
- Transcription and epigenetics (Reginato, Noguchi, Sell, Somarowthu)
- Apoptosis (Reginato, Noguchi)
- Aging (Noguchi, Sell)
Understanding structure-function relationships in biological macromolecules
- Membrane proteins (Loll, Chaiken)
- Cytoskeleton and signal integration (Padrick)
- Receptor-ligand interactions (Chaiken, Loll)
- Enzymology and drug design (Loll, Chaiken)
- Post-translational protein modifications (Noguchi, Reginato, Strochlic)
- Molecular-level studies of specific diseases, including:
- HIV and hepatitis (Chaiken, Abrams)
- Malaria (Vaidya)
- Sepsis (Loll)
- Neurodegenerative disease (Loll, Saunders)
- Aging (Noguchi, Sell)
- Infertility and developmental defects (Berkowitz, Strochlich)
Another initiative arising from this approach is in the development of small molecule inhibitors (Loll, Chaiken, Reginato), including development of new antibiotics (Loll).
Contact Us
Department of Biochemistry and Molecular Biology
245 N. 15th Street, 11102 New College Building, MS #497
Philadelphia, PA 19102
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