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Liang Oscar Qiang

Liang Oscar Qiang, PhD

Research Assistant Professor


Department: Neurobiology & Anatomy

Education

  • PhD in Molecular and Cell Biology and Genetics - Drexel University College of Medicine (2009)
  • MS in Anatomy - Nantong University College of Medicine (2003)
  • MD - Nantong University College of Medicine (2000)

Awards & Honors

  • Columbia University, Patent of Human induced neuron induction (2011)
  • Drexel University, Bondi Graduation Award for excellent thesis (2009)
  • Philadelphia Chapter of Society for Neuroscience, 2nd best poster presentation (2008)
  • Drexel University, Bondi Fellowship Award for excellent research student (2007)
  • Drexel University, GRID Critical Research Fellowship (University Grant) (2005)
  • Drexel University, First Place in Platform Presentation, Annual Research Day (2004)
  • Ministry of Transportation, China, Wufu-Zhenghua Fellowship for Outstanding Medical Students (1999)

Memberships / Professional Affiliations

  • American Society for Cell Biology
  • American Society for Neuroscience
  • American Society for Neuroscience

Postgraduate Training / Additional Certifications

Postdoctoral Research Scientist, Columbia University Medical Center: Asa Abeliovich, Advisor
Liang Oscar Qiang, MD, PhD, is a research assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine.

Research Interests

Neurological disease modeling and potential therapies using iPSC-derived neurons, as well as other cellular reprogramming strategies

Research

Dr. Qiang completed his MD and MS at Nantong University in 2000 and 2003, respectively, and his PhD at Drexel in 2009. His dissertation was "Functional Analyses of Microtubule Severing Proteins in the Central Nervous System." He then did postdoctoral research in the laboratory of Asa Abeliovich at Columbia University Medical Center, where he studied pathological mechanisms and potential therapeutic approaches Alzheimer's and Parkinson's diseases.

In 2013 he became a principal scientist at Angriocrine Bioscience, where he investigated the blood brain barrier in vitro, in an effort to support drug screening for the central nervous system. He also explored the microvasculature platform/niche to expand and differentiate embryonic and adult neural progenitor cells for therapeutic application, and generated CNS-derived microvasculature environment to support neuronal reprogramming.

Publications

"Instant neurons: directed somatic cell reprogramming models of CNS disorders"
Qiang L, Inoue K and Abeliovich A
Biol Psychiatry. pii: S0006-3223(13) 01107-4, Dec 22, 2013

"Re-modeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders"
Qiang L, Fujita R and Abeliovich A
Neuron 19;78(6):957-69, 2013

"Transcriptome wiring analysis implicates α-Synuclein 3’UTR selection in Parkinson’s disease"
Rhinn H, Qiang L, Yamashita T, Rhee D, Zolin A , Vanti W  and Abeliovich A
Nat. Commun;3:1084. doi: 10.1038/ncomms2032, Sep 25, 2012

"Basic Fibroblast Growth Factor Elicits Formation of Interstitial Axonal Branches via Enhanced Severing of Microtubules"
Qiang L, Yu W, Liu M, Solowska J, Baas PW
Mol Biol Cell. 21 (2): 334-44, Monthly “Incyte” Article of MBoC, a candidate of paper of 2010

"The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches"
Yu W*, Qiang L*, Solowska J, Baas PW
Mol Biol Cell. 19 (4): 1485-98 (* co-first author), 2008

"Tau protects microtubules in the axon from severing by katanin"
Qiang L, Yu W, Andreadis A, Luo M and Baas PW
J Neurosci. 26 (12):3120-3129, 2006

"Microtubules cut and run"
Baas PW, Karabay A, Qiang L
Trends Cell Biol. 15(10):518-24, 2005

"Regulation of microtubule severing by katanin subunits during neuronal development"
Yu W, Solowska JM, Qiang L, Karabay A, Baird D, Baas PW
J. Neurosci. 25 (23): 5573-5583, 2005

"Neuronal microtubules: when the MAP is the roadblock"
Baas PW, Qiang L
Trends Cell Biol. 15 (4): 183-187, 2005

"Bidirectional inhibitory interactions between the embryonic chicken metanephros and lumbosacral nerves in vitro"
Silver L, Qiang L, Loudon R, Gallo G
Dev. Dyn. 231 (1): 190-198, 2004

Presentations

"Severing of microtubules is tightly regulated during neuronal morphogenesis"
Qiang L, Yu W, Liu M, Solowska J and Baas PW
Poster Presentation, 48th Annual Conference of American Society for Cell Biology, San Francisco, Calif., 2008

"Spastin is more specialized than P60-katanin to participate in the formation of axonal branches"
Qiang L, Yu W, Baas PW
Poster Presentation, 47th Annual Conference of American Society for Cell Biology, Washington, D.C., 2007

"Tau regulates the severing of microtubules in the axon by katanin"
Qiang L, Yu W, Andreadis A, Luo M, Baas PW
Platform Presentation, Annual Conference of American Society for Neurochemistry, Portland, Ore., 2006

"Tau regulates the severing of microtubules in the axon by katanin"
Qiang L, Yu W, Andreadis A, Luo M, Baas PW
Poster Presentation, 45th Annual Conference of American Society for Cell Biology, San Francisco, Calif., 2005


Contact Information


Academic Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Lab: QL Room 185
Phone: 215.991.8280
Fax: 215.843.9082