Professor of Epidemiology
Epidemiology and Biostatistics
267.359.6049
ll85@drexel.edu
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Degrees

MD, Preventive Medicine, Shanxi Medical University, Taiyuan, China
MSc, Epidemiology, London School of Hygiene and Tropical Medicine, University of London, UK
PhD, Epidemiology, The University of Hong Kong, Hong Kong, China

Bio

Dr. Longjian Liu, MD, MSc, PhD, FAHA, is a tenured Full Professor of Epidemiology at Drexel University’s Dornsife School of Public Health and an Adjunct Associate Professor at Drexel University College of Medicine. With training in medicine, public health, and epidemiology from institutions in China, the United Kingdom, and Hong Kong, Dr. Liu’s research focuses on cardiometabolic diseases, brain aging, and global health.

Dr. Liu has led and collaborated on numerous NIH-funded studies, contributing to major U.S. cohort studies and national health surveys, including MESA, ARIC, WHI, HRS, JHS, NHANES, BRFSS, and MEPS. His international research collaborations include NIPPON DATA in Japan, CHARLS in China, and World Health Organization–coordinated studies, including the CARDIAC Study and the World Health Survey (WHS). He has published more than 130 peer-reviewed articles, as well as textbooks and book chapters.

Dr. Liu actively serves on grant review panels for the National Institutes of Health (NIH), the U.S. Environmental Protection Agency (EPA), the Agency for Healthcare Research and Quality (AHRQ), the UK Medical Research Council (MRC), and other national research agencies.

Since joining Drexel University in 2005, Dr. Liu has taught undergraduate and graduate courses in epidemiology and public health and mentored numerous MPH, MS, and PhD students. His previous academic appointments include positions at Shanxi Medical University and Chongqing Medical University in China, Shiga University of Medical Science and Kyoto University in Japan, and the University of Arkansas for Medical Sciences in the United States.

Courses

EPI 749: Research and Practice in Epidemiology

EPI 557: Cardiovascular Disease Epidemiology and Prevention

EPI 559: Pharmacoepidemiology

Research Interests

• Cardio-kidney-metabolic (CKM) disorders and their associated health outcomes
• Interactions among CKM disorders, genetics, and biologic aging clocks in relation to risk of CVD and AD/ADRD
• Application of artificial intelligence and machine learning in health outcomes research

Publications

Selected publications

Longjian Liu and Jintong Hou: Machine learning-based LASSO-Cox model for dementia prediction: The role of midlife cardiometabolic, inflammatory, and genetic risk factors in a US cohort. Annals of Epidemiology, 2026;115:28-36. PMID: 41581843.

Longjian Liu, Nathalie S. May, Yuwei Hou, Jingyi Shi, Edward J Gracely, Arthur L Frank, Howard J Eisen: The U.S. Diabetes Belt and Factors Explaining the Excess Risk: Multifactorial Modeling and Machine Learning Analysis. Primary Care Diabetes. 2026 Feb;20(1):99-105, PubMed, PMID: 41381318

Longjian Liu, Jintong Hou, Saishi Cui, Xiaopeng Zhao, Zuolu Liu, J. Craig Longenecker, Nathalie S. May, Jin Jun Luo, Rose Ann DiMaria-Ghalili, and Howard J. Eisen: Sex Differences in the Association of Vascular Risk and APOE Genotype on Cognitive Decline and Dementia: Evidence from a U.S. Longitudinal Study. The Lancet Regional Health – Americas, 2026;54:101346. PMID: 41536502, PMCID12796570.

Jacques E. Rossouw, Aaron K. Aragaki, JoAnn E. Manson, Emily D. Szmuilowicz, Laura B. Harrington, Karen C. Johnson, Matthew Allison, Bernhard Haring, Nazmus Saquib, Aladdin H. Shadyab, Kathryn M. Rexrode, Longjian Liu, Charles P. Mouton, and Andrea Z. LaCroix: Menopausal Hormone Therapy and Cardiovascular Diseases in Women With Vasomotor Symptoms: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials. JAMA Intern Medicine, Sept 2025, PMID: 40952729.

Longjian Liu, Edward J Gracely, Xiaopeng Zhao, Gediminas P Gliebus, Nathalie S. May, Stella L. Volpe, Jingyi Shi, Rose Ann DiMaria-Ghalili, and Howard J Eisen: Association of Multiple Metabolic and Cardiovascular Markers with Risk of Cognitive Decline and Mortality in Those with Alzheimer’s Disease and AD-related Dementia: A Prospective Cohort Study. Frontiers in Aging Neuroscience, 2024;2:16, PMCID: PMC11020085.

Tyler J. Titcomb, Phyllis Richey, Ramon Casanova, Lawrence S. Phillips, Simin Liu, Shama D. Karanth, Nazmus Saquib, Tomas Nuño, JoAnn E. Manson, Aladdin H. Shadyab, Longjian Liu, Terry L. Wahls, Linda G. Snetselaar, Robert B. Wallace, Wei Bao: Association of Type 2 Diabetes Mellitus with Dementia-related and non-Dementia-related Mortality among Postmenopausal Women: A Secondary Competing Risks Analysis of the Women’s Health Initiative. Alzheimer's & Dementia, Aug. 10, 2023, PubMed  PMIC: 37563765

Longjian Liu, Stella L. Volpe, Jennifer A Ross, Elisabeth J Van Bockstaele, and Howard J Eisen: Dietary Sugar Intake and Risk of Alzheimer’s Disease in Older Women. 2021 June, Nutritional Neuroscience. PubMed PMID 34328409.

Longjian Liu, Kathleen M. Hayden, Nathalie S. May, Bernhard Haring, Zuolu Liu, Victor W. Henderson, Jiu-Chiuan Chen, Edward J Gracely, Sylvia Wassertheil-Smoller, and Stephen R. Rapp: Association Between Blood Pressure Levels and Cognitive Impairment in Older Women: A Prospective Analysis of The Women’s Health Initiative Memory Study. The Lancet Healthy Longevity, 2022 Jan;3(1):e42-e53, PubMed, PMCID: PMC8804967

Longjian Liu: Heart Failure Epidemiology and Research Methods, Elsevier 2017.

Longjian Liu, Julianne Nelson, Carig J Newschaffer: Cardiovascular Disease, APHA Press (2010, 2016, and 2023).

See Dr. Lui's full list of key publications on PubMed