My research interest is to identify the molecular mechanisms, including changes in gene expression, translation and metabolism, by which cells adapt to hypoxia (low oxygen) and the dual stresses of oxygen and glucose deprivation.
Tumors become hypoxic as they reach a size of approximately 1-2 mm in diameter and outstrip the ability of the existing vasculature to supply oxygen and nutrients to the growing tumor. At this point, tumor cells can become hypoxic, as well as glucose deprived. Unless the tumor cells adapt to these stresses, the tumor will fail to grow and thus not become clinically relevant. Theoretically, blocking the ability of tumor cells to adapt to these stresses will block tumor growth and progression. The long-term goal of this work is to identify novel molecular targets for therapeutic development and diagnostic purposes.