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Gregg Johannes

Gregg Johannes, PhD

Assistant Professor


Department: Pathology & Laboratory Medicine

Education

  • PhD in Biological Sciences - University of South Carolina-Columbia
  • BS in Biochemistry - University of the Sciences in Philadelphia

Dr. Johannes is an assistant professor in the Department of Pathology & Laboratory Medicine at Drexel University College of Medicine.

Research Interests

Molecular diagnostics, cellular stress, hypoxia, glucose deprivation, stress-induced changes in gene expression, translation and cellular metabolism.

Research

My research interest is to identify the molecular mechanisms, including changes in gene expression, translation and metabolism, by which cells adapt to hypoxia (low oxygen) and the dual stresses of oxygen and glucose deprivation.

Tumors become hypoxic as they reach a size of approximately 1-2 mm in diameter and outstrip the ability of the existing vasculature to supply oxygen and nutrients to the growing tumor. At this point, tumor cells can become hypoxic, as well as glucose deprived. Unless the tumor cells adapt to these stresses, the tumor will fail to grow and thus not become clinically relevant. Theoretically, blocking the ability of tumor cells to adapt to these stresses will block tumor growth and progression. The long-term goal of this work is to identify novel molecular targets for therapeutic development and diagnostic purposes.


Contact Information


Academic Office

Department of Pathology & Laboratory Medicine
245 N. 15th Street
Room 5606
Philadelphia, PA 19102
Phone: 215.762.8173
Fax: 215.762.3978