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Erol Veznedaroglu

Erol Veznedaroglu, MD, FACS, FAANS, FAHA

Director, Drexel Neurosciences Institute; Robert A. Groff Chair in Neurosurgery


Department: Neurosurgery

Practices: Drexel Neurosciences Institute

Specialties: Neurosurgery

Education

  • MD - State University of New York at Buffalo School of Medicine (1996)
  • BA - New York University (1989)

Awards & Honors

  • NJ Biz Power 50 Health Care, 2014
  • Top Doctors, South Jersey Magazine, 2010-2013
  • Academics in Medicine Award, Mercer County, N.J., Medical Society, June 2013
  • Elected to Guide to America's Top Surgeons, 2007-2012
  • Doctor of the Year Finalist, NJ Biz, 2010
  • Who's Who in America, 2008

Memberships / Professional Affiliations

  • American Board of Neurological Surgeons
  • Society for Neuroscience
  • American Medical Association
  • American Association of Neurological Surgeons
  • Congress of Neurological Surgeons
  • Pennsylvania Medical Society
  • AANS/CNS Section on Cerebrovascular Surgeons
  • AANS/CNS Section on Neurotrauma and Critical Care
  • AANS Publications Committee
  • AANS Development Committee
  • Endovascular Neurosurgery Research Group
  • Congress of Neurological Surgeons Scientific Planning Committee
  • Congress of Neurological Surgeons Fellowship Committee
  • AANS Executive Committee for Critical Care and Neurotrauma
  • AANS Executive Committee Cerebrovascular Section
  • Society for Neurointerventional Surgery Senior Member
  • American College of Surgeons
  • New Jersey Health Care Quality Institute Board Member
  • Society of University Neurosurgeons
  • American Heart Association/American Stroke Association Central and Southern N.J. Board Member

Erol Veznedaroglu, MD, FACS, FAANS, FAHA, or Dr. Vez, is one of the nation's most innovative and experienced vascular, dual-trained neurosurgeons. He is director of the Drexel Neurosciences Institute and holds the Robert A. Groff Chair in Neurosurgery. Dr. Vez is also chair of Global Neurosciences Institute, LLC (GNI) leading a team of some of the nation’s most experienced neurosurgeons specializing in comprehensive care including vascular, tumor, spine and functional neurosurgery, as well as a consortium of neuroscience physicians providing subspecialty neurology and comprehensive pain management clinical services. This consortium includes experts in Alzheimer’s disease, Parkinson’s disease, comprehensive pain management, epilepsy, headache, pediatric neurology and autism. GNI is transforming the way neurologic treatment is delivered to patients in New Jersey and Pennsylvania.

Dr. Vez is the founder of the Capital Institute for Neurosciences at Capital Health. He previously served as director of the Division of Cerebrovascular and Endovascular Neurosurgery at Thomas Jefferson Hospital. He is board certified in neurological surgery, and is a fellow of the American College of Surgeons (FACS), the American Association of Neurologic Surgeons (FAANS) and the American Heart and Stroke Association (FAHA).

Clinical Services

Stroke, Aneurysms, Arteriovenous malformations (AVMs), Carotid and intracranial artery stenosis, Chiari malformations

Fellowships

  • Cerebrovascular/Neurointerventional Neurosurgery, Neurocritical Care - Thomas Jefferson Hospital for Neuroscience (2002-2003)

Residencies

  • Neurologic Surgery - Thomas Jefferson University Hospital (1997-2002)
  • Pediatric Neurosurgery - Children's Hospital of Philadelphia (7/1997-1/1998)
  • Complex Spine - Delaware Valley Regional Spinal Cord Injury Center (1999-2002)
  • Research: Gene Therapy for Prevention of Stroke - CNS Gene Therapy Center, Thomas Jefferson University (2000-2001)

Internships

  • General Surgery - Thomas Jefferson University Hospital (1996-1997)

Current Teaching Positions

Course Co-Director, AANS Endovascular hands on clinic for Neurosurgeons (Residents and Fellows), MERI Clinic Memphis TN, 2007-Present

Course Co-Director, AANS Complication Avoidance in Endovascular Neurosurgery Course, 2006-Present

Brain Awareness Week activities sponsored by the Philadelphia Chapter of the Society for Neuroscience, Franklin Science Museum, 2003-Present

Lecturer, Medical Neuroscience ID150, Small Group Clinical Conferences, Jefferson Medical College of Thomas Jefferson University (Course Coordinator:  Dr. George Brainard), 2002-present

Lecturer, Medical Neuroscience ID150, Grand Rounds, Endovascular Neurosurgery, Jefferson Medical College of Thomas Jefferson University (Course Coordinator:  Dr. George Brainard), 2001-present

Previous Teaching Positions

2014

Faculty, Simulation Based Neurosurgical Training
CNS Annual Meeting, Boston, Mass., Oct. 18, 2014

Co-Director, AANS Mid Level Annual Conference
Las Vegas, Nev. Sept. 2-5, 2014

Co-Director, Introduction to Endovascular Neurosurgery
for Residents
AANS Annual Meeting, San Francisco, Calif., April 5, 2014

2013

Co-Director, Open Vascular Neurosurgery Techniques Course for Residents
MERI Clinic AANS, Memphis, Tenn., Nov. 9-10, 2013

Co-Director, Endovascular Neurosurgery Techniques Course for Residents
MERI Clinic, Memphis, Tenn., Nov. 8-9, 2013

Faculty, Simulation Based Neurosurgical Training
CNS Annual Meeting, San Francisco, Calif., Oct. 20, 2013

Co-Director, Advanced Endovascular Techniques for Fellows AANS/SVIN/SNIS Combined MERI Course, Memphis, Tenn., Oct. 4-7, 2013

Simulation-Based Training for Residents  in Cerebral Bypass and Cerebral Angiography
European Association of Neurological Surgeons Annual Meeting, Prague, Czech Republic, Sept. 25, 2013

Co-Director, Junior Residents' Introduction to Cerebrovascular Neurosurgery Course
AANS Annual Meeting, New Orleans, La., April 27, 2013

Community Outreach Panel
5th Annual Neurosciences Conference, Revel Atlantic City, N.J., April 20, 2013

2012

Director, Endovascular Techniques for Fellows
MERI Course, AANS, Memphis, Tenn., Oct. 19-22, 2012

Director, Endovascular Techniques for Residents
MERI Course, AANS, Memphis, Tenn., Oct. 18-19, 2012

Faculty, Simulation-Based Neurosurgical Training
Congress of Neurological Surgeons, Chicago, Ill., Oct. 7, 2012

Faculty, Junior Fellows Endovascular Course
Mayfield Clinic, Jackson Hole, Wyo., June 16-17, 2012

Co-Director, NeuroNEXT Regional Technology Training for Fellows
MERI Clinic, Memphis, Tenn., April 3-4, 2012

Endovascular Simulation with the Masters Demonstration, Stent-Assisted Coiling of Cerebral Aneurysms
AANS/CNS Cerebrovascular Meeting, New Orleans, La., Jan 30, 2012

Co-Director, Hands on Simulation Course for Fellows
AANS/CNS Cerebrovascular Section Meeting, New Orleans, La., Jan. 28-29, 2012

2011 

Simulation-Based Neurosurgical Training
Annual CNS Meeting Practical Course, Washington, D.C., Oct. 2, 2011

Director, Endovascular Techniques for Residents
MERI Course AANS, Memphis, Tenn., Sept. 23-25, 2011

Meeting Chair, Third Annual Cerebrovascular Update Conference for State of New Jersey, Atlantic City, N.J. May 4-5, 2011

Moderator, Advances in Endovascular Treatments
CNS  University Webinar, Jan. 27, 2011

Fundamentals of Angiography Resident Course
University of Florida, Gainesville, Fla., Jan 7-8, 2011

2010

Simulator-Based Training in Endovascular Techniques and Nuances 
CNS Annual Meeting, San Francisco, Calif., Oct 17, 2010

Residents Hands-on  Endovascular Practical Clinic
AANS/CNS Annual Section Meeting, San Antonio, Texas, Feb. 21, 2010

2009 and Earlier

Course Co-Director, Nuances of Cerebrovascular Surgery Hands-on Course 
AANS St. Louis University, St. Louis, Mo., July 24-27, 2009

Cordis Endovascular Residents Summit
Miami, Fla., March 4-6, 2009

Course Co-Coordinator, Clinical Mentorship in Neuroscience
College of Graduate Studies, Thomas Jefferson University, 2007-2008

Course Lecturer, Neurosurgery and Neurology Board Review for Residents
Jefferson Medical College of Thomas Jefferson University, 2005-2008

Faculty: Introduction to Endovascular Neurosurgery Hands-on Course
CNS Annual Meeting, Boston, Mass., 2008 

Lecturer, Translational Topics in Neuroscience
College of Graduate Studies, Thomas Jefferson University, 2002-2008

Lecturer, Embryology
College of Graduate Studies, Thomas Jefferson University (Course Coordinator:  Dr. Gerald Grunwald), 2002-2008

Faculty: Introduction to Endovascular Neurosurgery Simulation Course
CNS, Chicago, Ill., October 7, 2006

Faculty, AANS Endovascular Hands-on Clinic for Neurosurgeons
MERI Clinic, Memphis, Tenn., March 31-April 2, 2006

Coordinator, Endovascular Techniques Clinic
American Association of Neurological Surgeons Meeting, San Diego, Calif., 2003 

Teaching Awards

  • William A Buchheit Teacher of the Year Award: 2004-2005, 2005-2006, 2006-2007, 2007-2008
  • Science Educator Award Society for Neuroscience (2005)

Research Overview

Dr. Vez's research interests include stroke, cerebral aneurysms, glioblastoma multiforme tumors, arteriovenous malformations, neurocritical care and neurovascular stenosis.

Research

Current Research


Stroke and TIA (mini-stroke)

Prevention

Aspirin and Plavix for Stroke Prevention
Response study: The study is being conducted to find out the effect omega-3 fatty acids have on subject responsiveness to dual-antiplatelet therapy after neuroendovascular stenting and on subject receiving dual antiplatelet therapy for stroke prevention.

Generalizable Knowledge

Impact of Emergency Department Discharge on TIA Rapid Assessment Outcomes: A Prospective Observational 90-Day Follow-Up Study (TIARA)
Veznedaroglu (PI)
This study measures outcomes following TIA to determine the impact standard practices (admission or discharge) on stroke and TIA recurrence.

Long Term Outcomes of Octogenarians with Acute Ischemic Stroke who Receive Endovascular Therapy
Veznedaroglu (PI)
This study will examine the long term outcomes in patients 80 years and above who have had an acute ischemic stroke and have received IV tPA, Heparin, and/or endovascular treatment.

Prehospital Stroke Alert (PHSA)
The primary aim of this study is to determine a decreased time from when the patient arrives to the hospital to when they receive IV tPA by delivering patients directly to CT for imaging, by passing ED triage. Published

Improved Door-to-Needle Times and Neurologic Outcomes When IV Tissue Plasminogen Activator Is Administered by Emergency Physicians with Advanced Neuroscience Training
This study demonstrated improved door to needle times and outcomes in Capital Health specialized neurological emergency department. 

Retrospective Study of Heparin Administration for Ischemic Stroke When There Is an IV-tPA Contraindication
Veznedaroglu (PI)
This study will analyze outcomes of patients that receive IV Heparin within 24 hours of symptom onset. The aims of the study are to compare early bleeding complications between patients administered heparin when they presented with contraindication to IV tPA but within 24 hours of ischemic stroke onset and also patient outcomes. Published

CLOT Retrieval
Study looking at the clinical significance of retrieving actual clot vs. not when performing thrombectomy for stroke. We would like to start prospectively collecting data and we will document during the procedure if we visualized a retrieved clot or not then will test the clinical significance. Endpoint Outcome: TICI 2b or better if clot retrieved or not.

Trevo-pro-retreiver in Acute Ischemic Stroke Patients
Veznedaroglu (PI)
Post-market single center analysis. Published

Stroke Incidence with CAS
Veznedaroglu (Co-PI)
A retrospective review of stroke incidence following carotid angioplasty and stenting in carotid stenosis patients.

Emergent Treatment

DAWN–Trial - DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-up and Late Presenting Strokes Undergoing Neuro-intervention
Veznedaroglu (PI)
To evaluate the hypothesis that Trevo thrombectomy plus medical management leads to superior clinical outcomes at 90 days as compared to medical management alone in appropriately selected subjects experiencing an acute ischemic stroke when treatment is initiated within 6-24 hours after last seen well.

POSITIVE - Perfuson Imaging Selection of Ischemic Stroke Patients for Endovascular Therapy
Veznedaroglu (PI)
The purpose of this randomized trial is to demonstrate the safety and efficacy of mechanical thrombectomy over medical therapy (MT) for treating acute ischemic stroke patients ineligible for IV-tPA with persistent symptoms within a 12 hour time window from symptom onset as selected by physiologic perfusion imaging criteria.

TREVO Registry
Veznedaroglu (Multi-site PI)
Prospective post – market registry of international sites for TREVO device for thrombectomy

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Aneurysm / AVM

Urgent Treatment

FRED
Veznedaroglu (PI)
The purpose of this study is to evaluate the safety and effectiveness of the MicroVention Flow Redirection Intraluminal Device (FRED) system when used in the treatment of wide-necked intracranial aneurysms.

WEAVE Wingspan Stent System Post Market Surveillance Study
Veznedaroglu (PI)
The purpose of this study is to offer the use of Wingspan Stent and Gateway Balloon Catheter devices for treatment of patients with neurovascular disease, including recurrent stroke refractive to medical therapy.

Multi-Center Chart Reviews

CN Deficit Fate After PED Aneurysm Treatment
Veznedaroglu (PI)
Retrospective chart review unruptured intracranial aneurysm presenting with cranial neuropathy and treated with flow diversion.

Endovascular Therapy of Venous Thrombosis
Veznedaroglu (PI)
Evaluate the efficacy of different endovascular devices for the treatment of venous sinus thrombosis.

Endovascular Treatment of Dual Arterio-venous Fistulas: A Retrospective Review Veznedaroglu (PI)

Multicenter Outcomes after Treatment of Unruptured AVMs (ARUBA AVM)
Veznedaroglu (PI)
Review of our data and previous published literature shows that the rate of hemorrhagic strokes treated in ARUBA is significantly higher than previously reported. Our goal in this study to publish our thoughts on the fallacies of ARUBA trial and support it with data of results after interventional from similar cohort of treated unruptured AVMs.

Retrospective Recording and Analysis of Patient Outcomes Following Cyberknife Treatment in Arterio-Venous Malformations (AVM) in the Brain
This study will evaluate AVM treatment protocols and outcomes to ascertain if CyberKnife provides at least the same or better morbidity and mortality rates.

Generalizable Knowledge

Intracranial Aneurysm Treatment and Outcome by Dual-trained Neurosurgeons at a Single Center
Veznedaroglu (PI)
This is a retrospective review of both ruptured and unruptured aneurysm treatments and outcomes by dual trained neurosurgeons at Capital Health System, Inc. hospitals since commencement of neurosurgery. The hypothesis proposes to validate that aneurysm treatment for this patient population has evolved over time and new trends have developed in treatment paradigms.

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Neuro-Oncology

Intra-arterial Avastin
Veznedaroglu (PI/IND holder)
High grade Gliomas in patients with gliobastoma multiforme, we will administer the chemotherapy, avastin, directly into the brain tumor via intra-arterial intracranial delivery. Delivery of chemotherapy directly to the brain tumor is a cutting edge method that may spare the patient the systemic side effects of the chemotherapy and allow for a more concentrated dose of the drug.

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Neurology

PFO Study
Association between atrial arrhythmia and patent foramen ovale (PFO) in ischemic stroke and transient ischemic attack patients.

Predicting Cognitive Improvement in Patients with Normal Pressure Hydrocephalus
Veznedaroglu (Co-PI)
This study aims to identify biomarkers (white matter tracks and tau/ amyloid protein profiles) to predict cognitive response following shunting in NPH patients.

Pyridoxine Levels and Treatment in Refractory Status Epilepticus
This project aims to determine the baseline levels of pyridoxine in patients with status epilepticus and the impact of pyridoxine supplementation on seizure frequency.

Recombinant Factor VIIa Use in Patients Presenting with Intracranial Hemorrhage
The objectives of this study are to review the usage of recombinant factor VIIa at Capital Health for intracranial hemorrhage, evaluate the effectiveness of the doses used and adverse event data in the course of treatment. Published

The Impact of the Endo-vascular Treatment of Cerebral Aneurysms on Headaches and Other Neurological Outcomes
This is a cross sectional, prospective, open label study to examine the impact of the endo-vascular treatment of cerebral aneurysms on headaches and other neurological outcome including seizures and data to day function.

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In the Media

Publications

Recent Peer-Reviewed Publications

"Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct"
Nogueira RG, Jadhav AP, Haussen DC, et al
New England Journal of Medicine, November 11, 2017

"Recombinant factor VIIa use in patients presenting with intracranial hemorrhage"
Yampolsky N1, Stofko D2, Veznedaroglu E2, Liebman K2, Binning MJ
Springerplus; 3:471, Aug 27, 2014

"Early Postmarket Experience After FDA Approval With the Trevo Device for Thrombectomy for Acute Ischemic Stroke"
Binning MJ, Adel JG, Maxwell CR, Liebman K, Hakma Z, Diaz C, Silva R, Veznedaroglu E
Neurosurgery, Aug 13, 2014

"P-021 TREVO Stent-Retriever Acute Stroke (TRACK) Post-marketing Registry: Interim Revascularization and Clinical Outcome Results Compared to TREVO-2 and NASA Registry"
Zaidat O, Castonguay A, Veznedaroglu E, Binning M, Alshekhlee A, Abraham M, Mehta S, El Khoury R, Majjhoo A, Lin E, Kabbani M, Froehler M, Nguyen T
J Neurointerv Surg;6 Suppl 1:A31-2, Jul 2014

Endovascular coil embolization of unruptured posterior communicating artery aneurysm.
Binning M, Hakma Z, Veznedaroglu E
Neurosurg Focus;37(1 Suppl):1. doi: 10.3171/2014.V2.FOCUS14179. PMID: 24983726, July 2014

"Retrospective study of Heparin Administration for Ischemic Stroke when there is an IV-tPA Contraindication"
Hakma Z, Stofko DL, Binning MJ, Liebman K, Veznedaroglu E
Surg Neurol Int; 5:62. May 6, 2014

"Wax on, wax off: a rare case of catatonia"
Greenberg K, D'Ambrosio M, Liebman KM, Veznedaroglu E
Am J Emerg Med. pii: S0735-6757(14)00235-6. doi: 10.1016/j.ajem.2014.03.047. [Epub ahead of print], Apr 3, 2014

"The neurological emergency room and prehospital stroke alert: the whole is greater than the sum of its parts"
Binning MJ1, Sanfillippo G, Rosen W, Dʼambrosio M, Veznedaroglu E, Liebman K, Diaz C, Silva R, Eichorn D, Rubin M
Neurosurgery ; 74(3):281-5, Mar 2014

"Endovascular advances for intracranial occlusive disease"
Binning MJ1, Veznedaroglu E
Neurosurgery;74 Suppl 1:S126-32, Feb 2014

"Endovascular treatment of acute ischemic stroke: the end or just the beginning?"
Mokin M1, Khalessi AA, Mocco J, Lanzino G, Dumont TM, Hanel RA, Lopes DK, Fessler RD 2nd, Ringer AJ, Bendok BR, Veznedaroglu E, Siddiqui AH, Hopkins LN, Levy EI
Neurosurg Focus;36(1):E5, Jan 2014

"Experience with a simulator based angiography course for neurosurgical residents: beyond a pilot program"
Fargen KM, Arthur AS, Bendok BR, Levy EI, Ringer A, Siddiqui AH, Veznedaroglu E, Mocco J
Neurosurgery;73 Suppl 1:S46-50, Oct 2013

"Mechanisms of Endothelial Cell Attachment, Proliferation, and Differentiation on 4 Types of Platinum-Based Endovascular Coils"
Pandey AS, San Antonio JD, Addya S, Surrey S, Fortina PM, Van Bockstaele EJ, Veznedaroglu E
World Neurosurg, doi:pii: S1878-8750(13)01050-4. 10.1016/j.wneu.2013.08.029. [Epub ahead of print] Aug 30, 2013

"Solitaire Flow Restoration thrombectomy for acute ischemic stroke: retrospective multicenter analysis of early postmarket experience after FDA approval"
Mokin M, Dumont TM, Veznedaroglu E, Binning MJ, Liebman KM, Fessler RD 2nd, To CY, Turner RD 4th, Turk AS, Chaudry MI, Arthur AS, Fox BD, Hanel RA, Tawk RG, Kan P, Gaughen JR Jr, Lanzino G, Lopes DK, Chen M, Moftakhar R, Billingsley JT, Ringer AJ, Snyder KV, Hopkins LN, Siddiqui AH, Levy EI
Neurosurgery. 2013 Jul;73(1):19-25; discussion, July 2013

"Endovascular treatment of intracranial atherosclerotic disease"
Lenart CJ, Binning MJ, Veznedaroglu E
Neuroimaging Clin N Am;23(4):653-9. doi: 10.1016/j.nic.2013.03.012 (Epub Jun 13 2013) Nov 2013

"Results of Membrane-Activated Chelator Stroke Intervention randomized trial of DP-b99 in acute ischemic stroke"
Lees KR, Bornstein N, Diener HC, Gorelick PB, Rosenberg G, Shuaib A, MACSI Investigators.
Stroke. 2013 Mar;44(3):580-4. doi: 10.1161/STROKEAHA.111.000013 (Epub Feb 7, 2013) Mar 2013

"Solitaire FR Thrombectomy for Acute Ischemic Stroke: Retrospective Multicenter Analysis of Early Postmarket Experience after FDA Approval"
Mokin M, Dumont TM, Veznedaroglu E, et al
Neurosurgery, Feb 25, 2013

Presentations

Recent Presentations

Acute and Hemorrhagic Stroke: a New Frontier
Visiting Professor, Georgetown University Hospital,  Washington D.C. December 4, 2014

Neurovascular Update: Intrasaccular Aneurysm Devices
Congress of Neurological Surgeons, Boston, Mass., October 18, 2014

Building a Comprehensive Stroke Center: Building a Program, Establishing a Center of Excellence, and Achieving Joint Commission CSC Accreditation
Congress of Neurological Surgeons, Boston, Mass., October 18, 2014

Controversies in Vascular Neurosurgery (Moderator)
Congress of Neurological Surgeons Annual Meeting, Boston Mass., October 20, 2014

Plenary Session: Treatment of Aneurysm Remnants
Congress of Neurological Surgeons Annual Meeting, Boston, Mass., October 21, 2014

Neurotrauma: the True Golden Hour
Honored Guest Lecture, 2nd Annual Trauma Conference, Kessler Rehabilitation Institute, West Orange, N.J., October 1, 2014

Study Update of Trevo Registry
Dinner Symposium: Society for Neurointerventional Surgery, Colorado Springs, Colo., July 25, 2014

Early Results of Trevo Stent Retrieval Study
Society for Neurointerventonal Surgery Annual Meeting, Colorado Springs, Colo., July 25, 2014

Neuroscience Grand Rounds: Future of Neurosciences
Visiting Professor, Lennox Hill North Shore University Hospital, New York, N.Y., June 16, 2014

What Neuroscience Looks Like in 2014
Distinguished Visiting Professor, University of Buffalo Department of Neurosurgery Gates Vascular Institute, April 26, 2014

Controversies in Cerebrovascular Neurosurgery (Moderator)
AANS Annual Meeting, San Francisco, Calif., April 9, 2014

Multidisciplinary Treatment of AVM’s (Moderator)
AANS Annual Meeting, San Francisco, Calif. April 7, 2014

Cerebrovascular Emergencies
ANSPA Session of AANS Annual Meeting, San Francisco, Calif., April 5, 2014

Brainiacs Seminar: “What is Consciousness?” (Panelist)
Princeton Present Day Club, March 20, 2014

EMS Clinical Education Symposium
Gloucester County EMS/Rowan University EMS, March 23, 2013

* This physician's clinical practice is independent of Drexel University.


Contact Information


Academic Office

Drexel Neurosciences Institute
245 N. 15th Street, Room 7102
New College Building, 7th Floor
Philadelphia, PA 19102

Practice Office

Drexel Neurosciences Institute
219 N. Broad Street
The Arnold T. Berman, MD Building, 7th Floor
Philadelphia, PA 19107
Phone: 844.464.6387
Fax: 215.239.3037