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Joanne Morrisey

Joanne Morrisey

Research Instructor


Department: Microbiology & Immunology

Education

  • BA in Chemistry - Douglas College, Rutgers University

Joanne Morrisey is a research instructor in the Department of Microbiology & Immunology at Drexel University College of Medicine.

Research

Joanne Morrissey has served as a research instructor with the College of Medicine and its predecessor institutions since 1984. Prior to that she served as a research technician at Rockefeller University in New York, NY, and the supervisor of clinical rheumatology at Upjohn Corporation in Philadelphia.

Publications

Recent Full-Length Papers

"Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum"
Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB
Mol. Biochem. Parasitol., article in press 2012

"Branched tricarboxylic acid metabolism in Plasmodium falciparum"
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, and M Llinas
Nature, 469: 432, 2011

"Yeast dihydroorotate dehydrogenase as a new selective marker for Plasmodium falciparum transfection"
Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya KD, Phillips MA, Rathod PK, Mather MW, Vaidya AB
Mol. Biochem. Parasitol. 177:29-34, 2011

"Variations among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain functions"
Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, and AB Vaidya
Eukaryot Cell (epub) June 17, 2011

"ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption"
Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB
J. Biol. Chem. 286, 41312-41322, 2011

"Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum"
Painter HJ, Morrisey JM, and AB Vaidya
Antimicrob. Agents Chemother., 54: 5281-5287, 2010

"Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies"
Mather MW, Morrisey JM, and AB Vaidya.
Molecular and Biochemical Parasitology, 174: 150-153, 2010

"Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum"
Kortagere S, Welsh WJ, Morrisey JM, Daly T, Ejigiri I, Sinnis P, Vaidya AB, and LW Bergman
J. Chem. Inf. Model 50: 840-849, 2010

"Host-parasite interactions revealed by Plasmodium falciparum metabolomics"
Olszewski K, Morrisey JM, Wilinski D, Burns JM, Vaidya AB, Rabinowitz JD, and M Llinas
Cell Host & Microbe, 5, 1-9, 2009

"The validity of mitochondrial dehydrogenases as antimalarial drug targets"
Vaidya AB, Painter HJ, Morrisey JM, and MW Mather
Trends Parisitol., 24(1): 8-9, 2008

Recent Abstracts

"The Unusual Tricarboxylic Acid Metabolism in Plasmodium falciparum"
Hangjun Ke, Ian Lewis, Kellen Olszewski, Joanne M. Morrisey, Praveen Balabaskaran Nina, Michael W. Mather, Manuel Llinás, Akhil B. Vaidya
American Society of Tropical Medicine and Hygiene 60th Annual Meeting, Philadelphia, December 4-8, 2011

"Yeast Dihydroorotate Dehydrogenase as a New Selectable Marker in Plasmodium berghei Transfection"
Joanne M. Morrisey, Suresh M. Ganesan, Thomas Daly, Heather J. Painter, Hangjun Ke, Ramesh Gajjar, Pradipsinh K. Rathod, Margaret A. Phillips, Michael W. Mather, and Akhil B. Vaidya
Molecular Parasitology Meeting XXII, Woods Hole, Massachusetts, September 11-15, 2011

"Investigating the essentiality of the heme biosynthesis pathway in blood stage Plasmodium falciparum"
Hangjun Ke, Joanne M. Morrisey, Ian Lewis, Manuel Llinás, Michael Mather, Akhil Vaidya
Molecular Parasitology Meeting XXII, Woods Hole, Massachusetts, September 11-15, 2011

"The type II V-H+-pumping pyrophosphatase of the malaria parasite P. falciparum"
Ramanayake N, Morrisey JM, Harrison M, Kirk K, Saliba KJ, and AB Vaidya
IOCOPA XII 2010

"The glycine cleavage complex, a key player in one carbon metabolism, is not essential in blood stage P. falciparum"
Mather MW, Ganesan SM, Morrisey JM, Ke H, and AB Vaidya.
Molecular Parasitology Meeting 2009

"A complete tricarboxylic acid cycle is not required in P. falciparum blood stage parasites"
Ke H, Mather MW, Ganesan S, Morrisey JM, and AB Vaidya
John Hopkins Parasitology Meeting 2009

"Malate: Quinone oxidoreductase is essential mitochondrial dehydrogenase in blood-stage malaria parasites"
Ganesan SM, Morrisey JM, Mather MW, and AB Vaidya
John Hopkins Cell Biology Meeting 2009.

"A complete TCA cycle is not required in P. falciparum blood stage parasites"
Ke H, Mather MW, Olszewski K, Ganesan SM, Morrisey JM, Llinas M, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Role of mitochondrial dehydrogenases in blood stage malaria parasites"
Ganesan SM, Morrisey JM, Painter HJ, Mather MW, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"The unusual ATP synthase complexes in alveolate protists"
Balabaskaran Nina P, Dudkina N, Kane LA, Morrisey JM, Ke H, van Eyk JE, Boekema E, Mather MW, and ABVaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Mitochondrial functions in malaria parasites during in vivo infection"
Morrisey JM, Ganesan SM, Burns Jr., JM, Mather MW, and AB Vaidya
Molecular Parasitology Meeting, Marine Biological Laboratory, Woods Hole, MA, 2009

"Strain specificity in the requirement for mitochondrial electron transport in erythrocytic stage Plasmodium falciparum"
Ke H, Morrisey JM, Mather MW, and AB Vaidya
American Society of Tropical Medicine and Hygiene 57th Annual Meeting, New Orleans, Louisiana, December 7-11, 2008

"Is pyrimidine biosynthesis the only essential role for the electron transport chain in different strains of the malaria parasites Plasmodium falciparum at blood stage?"
Ke H, Morrisey J, Mather M, Painter H, and A Vaidya
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"A putative mitochondrial fission protein in the malaria parasite Plasmodium falciparum"
Balabaskaran Nina P, Ganesan SM, Daly T, Morrisey J, Bergman L, Mather M, and A Vaidya.
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"Investigation of the functions of mitochondrially targeted proteins in malaria parasites"
Ganesan SM, Morrisey JM, Painter HJ, Ke H, Mather MW, and AB Vaidya
Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, Maryland, October 6-7, 2008

"A putative mitochondrial fission protein in Plasmodium falciparum"
Mather MW, Balabaskaran Nina P, Daly T, Morrisey JM, Bergman LW, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Strain specificity in the requirement for mitochondrial electron transport in erythrocytic stage Plasmodium falciparum"
Ke H, Morrisey JM, Mather MW, Painter HJ, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Type-I dihydroorotate dehydrogenase as a selectable marker for Plasmodium falciparum transfection to investigate mitochondrial functions"
Ganesan SM, Morrisey JM, Painter HJ, Mather MW, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Plasmodium falciparum survival in the presence of mitochondrial inhibition is dependent upon balancing pyrimidine nucleotide pools"
Painter HJ, Morrisey J, and AB Vaidya
Molecular Parasitology Meeting XIX, Woods Hole, Massachusetts, September 21-25, 2008

"Plasmodium metabolomics reveals a link between parasite-induced hypoarginemia and cerebral malaria"
Olszewski K, Morrisey J, Burns J, Vaidya A, Rabinowitz J, and M Llinas"
JHMRI 2008

"Homoloques of a Human Type II diabetes drug Target in Malaria parasites"
Ke H, Morrisey J, Mather M, and A Vaidya
JHMRI 2008

"Type-I Dihydroorotate dehydrogenase as a selectable marker for Plasmodium falciparum transfection to investigate mitochondrial functions"
Ganesan S, Morrisey J, Painter H, Mather M, and A Vaidya
JHMRI 2008

"Probing the plasmodium metabolome"
Olsewewski K, Rabinowitz J, Morrisey J, Burns J, Vaidya A, and M Llinas
ASMS 2008


Contact Information


Research Office

Department of Microbiology & Immunology
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8502
Fax: 215.848.2271