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Todd Strochlic

Todd Strochlic, PhD, VMD

Assistant Professor


Department: Biochemistry & Molecular Biology

Education

  • PhD in Cell and Molecular Biology – University of Pennsylvania (2008)
  • VMD – University of Pennsylvania, School of Veterinary Medicine (2008)

Awards & Honors

  • Scholarly Materials and Equipment Research Award, for Plasmid Library (2017)

Dr. Strochlic is an assistant professor in the Department of Biochemistry and Molecular Biology at Drexel University College of Medicine.

Research Overview

Dr. Todd Strochlic's research interests include protein kinases, oncogenic signaling, breast cancer and Drosophila oogenesis.

Research Interests

Protein kinases, oncogenic signaling, breast cancer, and Drosophila oogenesis.

Research

Protein kinases are key regulators of signal transduction pathways that mediate cell growth, proliferation, and motility. Via the addition of a phosphate group, these enzymes control the activity, localization, and/or function of substrate proteins. Consequently they play critical roles in normal development and are often dysregulated in various disease states. Most notably, protein kinases are frequently mutated in many human cancers and are often drivers of oncogenic signaling networks.

The work in Dr. Strochlic's lab is broadly centered on understanding certain protein kinase-mediated cell signaling pathways in the context of normal development and tumorigenesis. The lab uses a combination of genetic, biochemical, and cell biological approaches in both Drosophila melanogaster and mammalian cells to investigate the biology of several different protein kinases.

Publications

"Ack kinase regulates CTP synthase filament morphology and activity during Drosophila oogenesis"
Strochlic TI, Stavrides KP, Thomas SV, Nicolas E, O’Reilly AM, and Peterson JR 
Manuscript submitted.

"Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release"
Hartman TR, Strochlic TI, Ji Y, Zinshteyn D, and O’Reilly AM 
J. Cell Biol. 201: 741-757 (2013)

"Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking"
Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, and Peterson JR 
Proc. Natl. Acad. Sci.  USA 109: 4116-4121 (2012) 

"Phosphoinositides are essential co-activators for p21-activated kinase 1 (Pak1)"
Strochlic TI, Viaud J, Rennefahrt UE, Anastassiadis T, and Peterson JR
Mol. Cell  40: 493-500 (2010)

"Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome"
Strochlic TI
, Schmiedekamp BC, Lee J, Katzmann DJ, and Burd CG
Mol. Biol. Cell.  19: 4694-4706 (2008)

"Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling"
Strochlic TI
, Setty TG, Sitaram A, and Burd CG
J. Cell Biol. 177: 115-125 (2007) *recommended reading by the Faculty of 1000 (Biology)

"Arf-like GTPases: not so Arf- like after all"
Burd CG, Strochlic TI, and Gangi Setty SR 
Trends Cell Biol (review) 14: 687-694 (2004) 

"Golgi targeting of ARF-like GTPase Arl3p requires its N-alpha-acetylation and the integral membrane protein Sys1p"
Setty SR, Strochlic TI, Tong AH, Boone C, and Burd CG 
Nat. Cell Biol.  6: 414-419 (2004)


Contact Information


Research Office

Department of Biochemistry & Molecular Biology
245 North 15th Street
Mail Stop 497
Philadelphia, PA 19102
Phone: 215.762.3664
Fax: 215.762.4452