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Ying Jin

Ying Jin, PhD

Research Assistant Professor


Department: Neurobiology & Anatomy

Education

  • PhD - University of Hong Kong, China (1998)

Ying Jin, PhD, is a research assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine.

Research

My research interests are focused on acute, sub-acute and chronic spinal cord injury (SCI), in particular promoting axonal regeneration and functional recovery. I have been working on SCI using different injury models such as contusion, hemisection and transection; different treatments including cell transplantation (rodent neural stem cells, fetal spinal cord, peripheral nerve graft, human glial restricted progenitor, human embryonic stem cells and human induced pluripotent stem cells), biomaterials and gene therapy, and I have created a gradient for axonal growth. Recently I have been working on developing a new model for spinal cord concussion and studying the consequences of repeated spinal cord concussion, as well as combined spinal cord concussion and brain concussion on behavior and anatomy.

Publications

"Axonal regeneration of different tracts following transplants of human glial restricted progenitors into the injured spinal cord in rats"
Jin Y, Shumsky JS, and Fischer I
Brain Research (Accepted 2018)

"Guiding migration of transplanted glial progenitor cells in the injured spinal cord"
Yuan XB, Jin Y, Haas C, Yao L, Hayakawa K, Wang Y, Wang C, Fischer I
Scientific Reports, 6:22576. PMID:26971438 (2016)

"Neural Progenitor Cells Promote Axonal Growth and Alter Axonal mRNA Localization in Adult Neurons"
Tanuja Merianda, Ying Jin, Ashley Kalinski, Pabitra Sahoo, Itzhak Fischer, and Jeffery Twiss
eNeuro: DOI: 10.1523/ENEURO.0171-16.2017 PubMed PMID: 28197547 (2017)

"Transplantation of neural progenitor cells in chronic spinal cord injury"
Jin Y, Bouyer Y, Shumsky JS, Haas C., and Fischer I
Neuroscience, 320:69-82. PMID26852702 (2016)

"Spinal Cord Concussion: studying the potential risks of repetitive injury"
Fischer I, Haas C, Raghupathi R, and Jin Y
Neural Regeneration Research, 11(1): 58-60. PMID:26981079 (2016)

"Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors"
Hayakawa K, Haas C, Jin Y, Bouyer J, Otsuka T, Fischer I
Brain Research, 1629:113-25. PMID:26498878 (2015)

"Evaluation of the anatomical and functional  consequences of repetitive mild cervical contusion using a model of spinal concussion"
Jin Y, Bouyer J, Haas C, Fischer, I
Exp Neurol., 10;271:175-188. PMID:26070306 (2015)

"Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat"
Jin Y, Bouyer J, Haas C, Fischer, I
Exp. Neurol., 257:57-69. PMID:24786492 (2014)

"Transplanting neural progenitors into a complete transection model of spinal cord injury"
Medalha CC, Jin Y, Yamagami T, Haas C, Fischer I
J Neurosci. Res. Jan 3; 114(1):56-66. PMID:24122719 (2014)

"Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF"
Zhang C, Jin Y, Ziemba KS, Fletcher AM, Ghosh B, Truit E, Yurek DM, Smith GM
Exp. Neurol. 250:156-64. PMID: 24099728 (2013)

"Implications of poly(N-isopropylacrylamide)-g-poly(ethylene glycol) with co-dissolved brain-derived neurotrophic factor injectable scaffold on motor function recovery rate following cervical dorsolateral funiculotomy in the rat"
Grous LC, Vernengo J, Jin Y, Himes BT, Shumsky JS, Fischer I, Lowman A
Journal of Neurosurgery April 12. PMID: 23581453 (2013)

"Differential Effects of Distinct CNS Regions on Cell Migration and Axonal Extension of Neural Precursor Transplants"
Jin Y, Sura K, Fischer I
Journal of Neuroscience Research 90: 2065-2073 (2012)

"A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord"
Conova L, Vernengo J, Jin Y, Himes BT,  Neuhuber B, Fischer I, Lowman A
Journal of Neurosurgery, 15(6):594-604 (2011)

"Directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain"
Jin Y, Zhang C, Ziemba KS, Goldstein GA, Sullivan PG and Smith GM
J. Neurosci Res., 89(5):619-27 (2011)

"Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury"
Jin Y, Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli JT, Fischer I
Journal of Neurotrauma, 28:579-594 (2011)

"Chondroitinase activity can be transduced by lentiviral vector in vitro and in vivo"
Jin Y, Ketschek A, Jiang ZL, Smith GM, Fischer I
J Neurosci Methods 199: 208-213 (2011)


Contact Information


Research Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Office: Room 179A
Phone: 215.991.8314
Fax: 215.843.9082