AAR029b (macrocyclic peptide) Binding to HIV-1 Env CD4 Binding Pocket
HIV-1 YU2 gp120 ligand immobilized on CM5 sensor chip and AAR029b injected at increasing concentrations.
AAR029b Macrocyclic Peptide MW: 1003.4 Da
AAR029b (green sticks) docked into an HIV-1 trimer (5FUU) CD4 binding pocket. Red residues: W112 and S375. Rashad et al., J Med Chem. 2015; 58(18): 7603–7608.
Red arrows reveal the increased sensitivity and power of Biacore S200 compared to Biacore 3000.
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