For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

Pulse - Winter/Spring 2016 Drexel Neurosciences Institute Part of Landmark Study Investigating Drug to Delay or Prevent Alzheimer's Disease

Researchers at the Drexel Neurosciences Institute have begun a landmark study to determine if a new drug can postpone or even prevent Alzheimer's disease.

The study examines healthy people whose brain scans show the buildup of amyloid, a protein associated with the disease — but who do not yet have any memory loss or other symptoms. The study will determine if an investigational treatment can clear the built-up amyloid before the disease progresses and brain cells are impaired.

Neuron with amyloid plaques

Neuron with amyloid plaques

"This is truly an exciting and hopeful study. To find a way to prevent or delay Alzheimer's disease would have profound implications for patients and their families as well as for our nation," says Erol Veznedaroglu, MD, director of the Drexel Neurosciences Institute (DNI) and chairman of the Department of Neurosurgery at Drexel University College of Medicine.

More than 5 million Americans currently have Alzheimer's disease, according to the National Institute on Aging, and the numbers are expected to triple by 2050.

The principal investigator is Carol F. Lippa, MD, director of the Cognitive Neurology and Alzheimer's program at Drexel Neurosciences Institute. She says there is limited potential to reverse Alzheimer's once the disease is established and brain cells and neurons are destroyed.

"We believe the key — the real hope — is to clear amyloid plaques before they contribute to the destruction of brain cells in the thinking areas of the brain," Lippa says. "Clearing out the amyloid is like clearing out the kindling before the fire starts. We are hopeful we can prevent Alzheimer's and the enormous suffering that surrounds this disease." Sticky amyloid can form clumps, or plaque, that may block cell-to-cell signaling among neurons. Scans show this amyloid in the brain for years, even decades, before people experience any cognitive decline. Researchers believe the best hope is to stop the progression of amyloid plaques before symptoms of Alzheimer's begin.

"This is truly an exciting and hopeful study. To find a way to prevent or delay Alzheimer's disease would have profound implications for patients and their families as well as for our nation."

Also part of the research team is G. Peter Gliebus, MD, assistant professor of neurology at DNI.

The study, called A4, or Anti-Amyloid in Asymptomatic Alzheimer's Disease Study, looks at the investigational drug, solanezumab, to reduce plaque formation. The A4 Study is an international public-private partnership, funded by the National Institutes of Health, Eli Lilly and Company, and several philanthropic organizations. The Drexel Neurosciences Institute is one of 60 study sites around the world.

Lippa says the investigators are seeking patients who want to contribute to the science for altruistic reasons as well as those who may be concerned about developing Alzheimer's because someone in their family has the mind-robbing disease.

They are seeking a diversity of participants and are eager for people from the African-American community as well as those from ethnic minority communities to consider joining the study.

"We see Alzheimer's disease in all races and ethnicities," Lippa says.

Participants must be 65 to 85 years old, have normal thinking and memory abilities, and be willing to undergo a PET scan of their brain. Those with no sign of amyloids will be part of a separate study. Those with amyloids will receive IV infusions of the investigational treatment or a placebo every four weeks for three years and also undergo additional memory and medical tests. Lippa says participants will receive free tests to closely follow their medical health.

For more information, call 215.762.7037.

 Back to Top


Pulse is published four times a year for students, faculty, staff, alumni and friends of the College, highlighting innovations in research, clinical practice and education; key events; and accomplishments. News, professional and academic achievements, calendar items and story ideas may be submitted by email to