Research Fellows with Dr. Joshi
Bhaswati Sen, PhD; Rubina Narang (PhD student); Jennifer Scotti (rotation) and Peter Huh (MD students); Priya Dhagat, Brandon Fong and Rachel Figaro (MS students)

Dr. Joshi’s research areas are related to bacterial pathogenesis and biofilms, and wound infection and healing . He has extensive experience in the areas of antimicrobial resistance, nosocomial infection control strategies, and molecular and clinical epidemiology, drug development and animal infection models. He has also worked in the area of host cellular responses (with a special focus on apoptosis and mediation of NFkB and caspases) to bacterial pathogens and/or their virulence products. Joshi has developed several in vitro and in vivo assays, and has expertise in immunocytochemical (ICC) and immunohistochemical (IHC) detection systems and microscopies. He has initiated Surgical Infections Research (SIR) program at this institute, with a special emphasis to multi-drug resistant (MDR)- Acinetobacter and MRSA infection, runs biosafety level-2 plus (BSL2 +) bacteriology laboratory. The major current topics of research in Dr. Joshi's lab are:

• Carbapenem resistant-Acinetobacter baumannii: antibiotic resistance mechanisms, and pathogenesis of infection.
• Antimicrobial and anti-biofilm strategies: using atmospheric non-thermal plasma, novel antimicrobial sustained release, antimicrobial augmentation.
• Molecular diagnostic strategies for detection of multidrug-resistant bacterial pathogens and their virulence factors.  
• Botulinum toxin: host responses, vaccine development, novel diagnostic techniques.

Clinical Trials

• Novel beta-lactamase inhibitors with carbapenems against complicated intra-abdominal infection.
• Clinical response and efficacy of novel beta-lactamase inhibitor in urinary tract infection therapeutic regime.
• Effect of novel antimicrobial solution and its clinical efficacy in the management of atopic dermatitis (being submitted).

Collaborations

• A.J. Drexel Plasma Institute, Drexel University, Philadelphia
• Center for Botulism and Biodefense Research (CBBR), Thomas Jefferson University
• Institute of Molecular Medicine and Infectious Diseases, Dexel University College of Medicine
• School of Biomedical Engineering, Science and Health Systems, Drexel University
• KEM Hospital & Research Center, Pune, and University of Pune, Pune (India)
• Hadassah Hebrew University Medical Center, Jerusalem (Israel)

Honors

• UNESCO-ASM Visiting Resource Person, 2002, 2004
• National Judge & Evaluator for Annual Biomed Research Conf for Minority Students (ABRCMS), 2008, 2009, 2010
• International Mentoring Program & Minority Mentoring Program, American Society for Microbiology, and Infect Dis Society of America.
• Editorial Board Service to BMC Infectious Diseases (Associate Editor); Surgery: Current Research; World Journal of Clinical Infectious Diseases; Afr Journal of Infectious Diseases, International Journal of Bacteriology, ISRN Infectious Diseases, and Journal of Drug Development, Journal of Antibiotics Research, Journal of Immunology and Vaccination.

“Dr. Suresh Joshi Is Nominated as USA’s Technical Expert on the International Electrotechnical Commission (IEC)”
Drexel School of Biomedical Engineering, Science and Health Systems News (Mar 19, 2022)

“The Birthplace of Plasma Medicine, 20 Years Later”
Drexel News (Mar 17, 2022)

“2022 G.E.R.M. Awardees: Kira Zack, Medical Student, Drexel University College of Medicine: Project: CRAB & the role of potential molecular pump inhibitors in clinical medicine. Mentor: Suresh G. Joshi, Center for Surgical Infection and Biofilm, Drexel University. G.E.R.M. research awards are instituted by IDSA Foundation”
IDSA Foundation (2022)

“Suresh G. Joshi, MD, PhD is recognized and elected as fellow to Infectious Diseases Society of America (IDSA)”
(Aug 10, 2016)

“Eczema and Biofilms”
The Triangle (Feb 28, 2014)

“Research on Non-thermal Plasma Solutions”
Trove: National Library of Australia (Jun 1, 2013)

“Plasma-treated Alginate Wound Dressing”
Microbe Magazine (Feb 1, 2012)

Selected Publications

(See all Suresh Joshi's publications in PubMed.)

“Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii”
Zack KM. Sorenson T, Joshi SG
Pathogens 13(137): 1-32. (2024)

“The Birthplace of Plasma Medicine, 20 Years Later”
Joshi SG
Drexel News (Mar 17, 2022)

“An association of pathogens and biofilms with Alzheimer’s Disease”
Chakravarthi ST and Joshi SG
Microorganisms 10(1): 56-74. (2022)

“Evaluation of cellular and systemic toxicity of Dielectric-Barrier Discharge Plasma-Treated N-acetylcysteine as a potential Catheter Lock Solution”
Ercan UK, Yost AD, Wasko K, Brooks AD, Joshi SG
Plasma 4: 732-744 (2021)

“Carbapenem resistance in Acinetobacter baumannii and their importance in hospital-acquired infection: A Scientific Review”
Nguyen M and Joshi SG
Journal of Applied Microbiology 131(6): 2715-2738 (2021)

“Rapid, label-free genetic detection of enteropathogens in stool without genetic isolation or amplification”
Han S, Soylu MC, Kirimli CE, Wu W, Sen B, Joshi SG, Emery CL, Au G, Niu X, Hamilton R, Krevolin K, Shih WY
Biosensors and Bioelectronics 130: 73-80 (2019)

“The impact of biofilms in Alzheimer’s disease compared to other diseases in which they play a role”
Allen, HB, Cusack CA, Joshi SG
International Journal of Neurobiology 13: e1-e4 (2019)

“Alzheimer’s Disease: Possible mechanisms for worsening of the disease”
Allen HB, Allawh RM, Ilyas EN, Miklossy J, Joshi SG
Current Neurobiology 9(1): 59-65 (2018)

“Escherichia coli cellular responses to exposure to atmospheric-pressure dielectric barrier discharge (DBD) plasma-treated N-acetylcysteine (NAC) solution”
Ercan UK, Sen B, Brooks AD, Joshi SG
Journal of Applied Microbiology 124(2): 383-397 (2018)

“Bioethical challenges arising from the microbiology and pathology of Alzheimer’s Disease”
Allen HB, Allawh RM, Ilyas EN, Joshi SG
Current Neurobiology 9(1): 26-28 (2018)

“Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii”
Raible KM, Sen B, Law N, Bias T, Emery CL, Ehrlich GD, Joshi SG
Annals of Clinical Microbiology and Antimicrobials 16: 75-86 (2017)

“PVL toxin-producing methicillin-resistant Staphylococcus aureus (MRSA) is predominant in a tertiary-care metropolitan teaching hospital”
Kleinwaks LP, Leung B, Sen B, Emery CL, Hamilton RJ, Ari D. Brooks, Joshi SG
Canadian Journal of Infection Control 32(3): 143-145 (2017)

"Involvement of multiple stressors induced by non-thermal plasma-charged aerosols during inactivation of airborne bacteria"
Vaze ND, Park S, Brooks AD, Fridman A, Joshi SG
PLOS ONE 12(2): e0171434 (2017)

"Penicillin: The Old/New Wonder Drug (A review)"
Allen HB, Hossain C, Abidi N, Larijani M, Joshi SG
Advanced Techniques in Biology and Medicine; (51): 197-202, doi: 10.4172/2379- 1764.1000197 (2017)

"Atherosclerosis: the novel finding of biofilms and innate immune system activity within the plaques"
Allen HB, Boles J, Morales D, Ballal S, Joshi SG
Journal of Medical and Surgical Pathology 1(4): 135-140 (2016)

"Eczema: A proposed reclassification based on the signature pathology finding of occluded sweat ducts"
Allen HB, Warner CA, Joshi SG
Journal of Clinical and Experimental Dermatology Research 7 (2): 344-346 (2016)

"Alzheimer's disease: a novel hypothesis for the development and subsequent role of beta-amyloid"
Allen HB, Morales D, Jones K, Joshi SG
Journal of Neuroinfectious Diseases (7 (2): 211-213 (2016)

"Psoriasis: A sequela of streptococcal infection similar to acute rheumatic fever"
Allen HB, Miller B, Durkin J, Joshi SG
Clinical Microbiology Open Access 5 (2): 244-246 (2016)

"Alzheimer's disease: a novel hypothesis integrating spirochetes, biofilm, and the innate immune system"
Allen HB, Morales D, Jones K, Joshi SG
Journal of Neuroinfectious Diseases 7 (1): 200-202 (2016)

"Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution in Bacterial Inactivation"
Ercan UK. Smith J, Ji H-F, Brooks AD, Joshi SG
The Scientific Reports 6:20365, doi:10.1038/srep20365 (2016)

Additional Publications