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Wilbur B. Bowne

Wilbur B. Bowne, MD, FACS

Professor


Department: Surgery

Practices: Drexel Surgery, Drexel Cancer Care

Specialties: General Surgery, Surgical Oncology, Minimally Invasive Surgery

Education

  • MD - State University of New York Health Science Center of Brooklyn

Awards & Honors

  • Honorary co-chair, Pancreatic Cancer PurpleStride Philadelphia Walk [PDF] (2015)
  • The Lutheran Medical Center, Department of Surgery, Excellence in Teaching Award (2005)
  • The Mount Sinai School of Medicine, Student Council House Staff Excellence in Teaching Award (2002)
  • The Mount Sinai School of Medicine, Department of Surgery, Medical Student Teaching Award in Surgery (2002)
  • The David A. Dreiling Award for Academic Achievement, The Mount Sinai School of Medicine, Department of Surgery (2002)

Wilbur B. Bowne, MD, FACS, is a graduate of SUNY Downstate Medical School. He completed surgical training at Mount Sinai School of Medicine and surgical oncology laboratory and clinical fellowships at Memorial Sloan Kettering Cancer Center in New York. Thereafter, he obtained additional training in minimally invasive/laparoscopic surgery.

Prior to being recruited to Drexel University College of Medicine, Dr. Bowne served as chief of the Section of Surgical Oncology at Downstate Medical Center where he was the American College of Surgeons cancer liaison physician. Dr. Bowne's expertise includes surgery for the pancreas, liver, bile duct, and gastrointestinal tract.  He leads a multidisciplinary cancer team which offers a new state-of-the-art procedure, called hyperthermic intraperitoneal chemotherapy (HIPEC), to patients with advanced abdominal cancers, including colon, ovarian, appendiceal and gastric cancers, peritoneal mesothelioma, low-grade sarcomas, and pseudomyxoma peritonei. Dr. Bowne and this new breakthrough treatment option were featured in the April 2013 edition of Pulse [PDF].

He is extensively published with over 100 peer-reviewed articles, abstracts, and book chapters. He is a sought after speaker on the topic of gastrointestinal oncology. Dr. Bowne is also the recipient of numerous awards for teaching and extramural funding for his research in pancreatic cancer.

Dr. Bowne takes great pride in being a member of Drexel's multidisciplinary cancer team, which treats the most complex patient situations no matter the circumstances or nature of the condition.

Videos

Clinical Services

Minimally invasive surgery, Pancreatic disease, Hepatobiliary surgery, Surgical oncology, Gastrointestinal cancers, Pancreatic cancer and related diseases, Pseudomyxoma peritonei

Fellowships

  • Research - Memorial Sloan-Kettering Cancer Center (1996-1999)
  • Surgical Oncology - Memorial Sloan-Kettering Cancer Center (2002-2004)
  • Laparoscopic/Minimally Invasive Surgery - State University of New York Health Science Center of Brooklyn (2004-2005)

Residencies

  • Surgery - Mount Sinai School of Medicine, Mount Sinai Hospital (1999-2002)

Internships

  • Surgery - Boston University School of Medicine (1994-1996)

Wilber B. Bowne, MD, is a professor in the Departments of Surgery and Biochemistry & Molecular Biology at Drexel University College of Medicine. He has mentored many graduate students, residents and medical students and has received numerous teaching awards.

Academic Appointments

Weill Medical College, Cornell University

  • Clinical Instructor in Surgery (2002–2004)

State University of New York- Health Science Center of Brooklyn

  • Assistant Professor of Surgery, Section of Surgical Oncology, School of Graduate Studies - Molecular and Cellular Biology (2005–2011)

Research Interests

Cell-cycle regulation, Peptide therapeutics - pancreatic cancer, Pancreatic and liver disease, Serologic tumor marker detection, Oncoproteins, Early tumor detection, Evaluation of abdominal masses

Research

Dr. Bowne is a productive researcher and has extensively published on cell-cycle regulation and peptide therapeutics against pancreatic cancer for which he was awarded the prestigious ACS Faculty Fellowship Research Award in 2010. In addition, he has co-authored several text book chapters on pancreatic and liver disease, serologic tumor marker detection, oncoproteins, early tumor detection, and evaluation of abdominal masses in ACS-Principles and Practices of Surgery.

Selected Research

"Understanding Colon Cancer Racial Health Disparity - Phosphosulindac, miRNAs and cancer racial disparity"
Principal Investigator: W.B. Bowne
Pending approval by IRB (2011)

"Examining the Mechanism of action of PNC-28 in a Syngeneic Rat Pancreatic Tumor Model"
Principal Investigator: W.B. Bowne
Approved by IACUC (2007-2008)

"Anti-tumor effects of novel peptides and genetic immunization with oncogenic ras-p21 domains in pancreatic cancer"
Principal Investigator: W.B. Bowne
(2006-current)

"A Prospective Study on the Yield of Magnetic Resonance Cholangiopancreatography (MRCP), Positron Emmision Tomography (PET)"

"Vaccination of AJCC Stage III and IV Melanoma Patients with Tyrosinase Peptide plus Immunological Adjuvant Plasmid GM-CSF"
A protocol for evaluating the immunogenicity, antitumor effects and toxicity of plasmid GM-CSF plus peptide Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val(YMDGTMSQV)
Principal Investigator: J.J. Lewis, Coinvestigator: W.B. Bowne
(1999)

"Anti-tumor Applications of Gene Gun Genetic Immunization."
A protocol for the evaluation of specific immune reactivity against tumor antigens delivered by genetic immunization
Principle Investigator: A.N. Houghton, Coinvestigator: W.B. Bowne
IACUC (1999)

In the Media

Publications

Selected Publications

"Anti-Cancer Peptides from the Ras-P21 Proteins"
M.R. Pincus, M. Fenelus, E.S. Yahzdi, V.Adler, W.B. Bowne and J. Michl
Current Pharmaceutical Design, In press, (2011)

"The Anti-cancer peptide, PNC-27, adopts an hdm-2 binding conformation in solution and binds to hdm-2, uniquely expressed in the membranes of cancer cells, resulting in transmembrane pore formation and cancer cell death"
E.S. Yahzdi, W.B. Bowne, V. Adler, K.A. Sookraj, V. Wu, V. Shteyler, H. Patel, W. Oxbury, P. Brandt-Rauf, M.E. Zenilman, J. Michl and M.R. Pincus
Proceedings of the National Academy of Science USA, 107 (5): 1918-23 (February 2010)

"PNC-27 acts as the intact peptide in inducing pore formation to occur in the membranes of cancer cells"
K.A. Sookraj, W.B. Bowne, V. Adler, E.S. Yhazdi, V. Wu, H. Patel, W. Oxbury, J. Michl and M.R. Pincus
Cancer, Chemotherapy, and Pharmacology, 66(2):325-31 (July 2010)

"Perforated Appendicitis Presenting as a Thigh Mass"
K.A. Sookraj, W.B. Bowne and B.C. Ghosh
The Journal of the American College of Surgeons, 208, (6): 1142 (2009)

"IgE Antibodies from Pancreatic Cancer Patients Mediate Antibody-Dependent Cell Mediated Cytotoxicity (ADCC) Against Pancreatic Cancer Cells"
S.L. Fu, S.L. Pierre, T. Smith-Norowitz, M. Hagler, W.B. Bowne, M.R. Pincus, C.M. Mueller, M.E. Zenilman and M.H. Bluth
Clinical and Experimental Immunology, 153(3):401-9 (September 2008)

"Sophorolipids and their Derivatives are Lethal Against Human Pancreatic Cancer Cells"
S. Fu, S. Wallner, W.B. Bowne, M.E. Zenilman, R. Gross and M.H. Bluth
Journal of Surgical Research, 148 (1): 77-82 (2008)

"Two Peptides Derived from ras-p21 Induces Either Phenotypic Reversion or Tumor Cell Necrosis of ras-Transformed Human Cancer Cells"
V. Adler, W.B. Bowne, K. Ikram, J. Michl, F.K. Friedman, E. Chin, M.E. Zenilman and M.R. Pincus
Cancer, Chemotherapy and Pharmacology, 62(3):491-8 (August 2008)

"The Role of the Assistant in Laparoscopic Surgery: Important Considerations for the Apprentice in Training"
A. Chui, W.B. Bowne, K.A. Sookraj, A. Fingerhut, M.E. Zenilman and G.S. Ferzli
Surgical Innovation, 15(3):229-36 (September 2008)


Contact Information


Practice Office

Drexel Surgery
219 N. Broad Street
The Arnold T. Berman, MD Building, 8th Floor
Philadelphia, PA 19107
Phone: 215.762.1647
Fax: 215.762.8389