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Vitaliy Marchenko

Vitaliy Marchenko, MD, PhD

Research Assistant Professor


Department: Neurobiology & Anatomy

Education

  • PhD in Biology and Medicine - Bogomoletz Institute of Physiology of Ukraine Academy of Science (1997)
  • MD - Dnipropetrovsk Medical Institute (1982)

Dr. Marchenko is a research assistant professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine.

Research Overview

Research interests:

  • Neural control of cardiovascular and respiratory function
  • Synchronous oscillations in motor neuron pools
  • Optical imaging of electrical activity of respiratory and cardiovascular bulbospinal networks
  • Spike train encoding and decoding

Research Interests

Neural control of cardiovascular and respiratory function

Research

Dr. Marchenko spent a number of years in clinical practice as general surgeon and later as neurosurgeon in emergency hospital services in Ukraine. His PhD thesis was devoted to central mechanisms of respiratory rhythm generation.

After obtaining his PhD, he held research positions at Albert Enstein College of Medicine in Bronx, N.Y. (1997-1998), New Jersey Medical School (1998-2000), University of Pennsylvania (2000-2003), the University of Delaware (2003-2008), and the Daniel Baugh Institute for Functional Genomics and Computational Biology in Philadelphia (2008-2009).

Dr. Marchenko's research goals are focused mainly on central mechanisms of cardiorespiratory and locomotor network plasticity and reconfiguration during transition from normal breathing to gasping under deep anoxia. By using experimental approaches such as in vivo and in situ electrophysiology, functional optical imaging, microinjection techniques and application of information theory, he seeks to understand how different type of neuronal cells, neurotransmitters and second-messenger intracellular systems  are involved  in changing of sensory information processing from peripheral (respiratory and cardiovascular) receptors and synchronous activity of motoneuron pools under such pathological condition as severe hypoxia.

Publications

Selected Publications

Respiratory Recovery Following Spinal Cord Injury:

"Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury"
Hormigo KM, Zholudeva LV, Spruance VM, Marchenko V, Cote MP, Vinit S, Giszter S, Bezdudnaya T, Lane MA.
Exp Neurol. 2017 Jan;287(Pt 2):276-287.

"Supraspinal respiratory plasticity following acute cervical spinal cord injury"
Bezdudnaya T, Marchenko V, Zholudeva LV, Spruance VM, Lane MA.
Exp Neurol. 2017 Jul;293:181-189.

"Integration of Transplanted Neural Precursors with the Injured Spinal Cord"
Spruance VM., Zholudeva LM, Hormigo KM, Randelman ML, Bezdudnaya T, Marchenko V, Lane MA.
J Neurotrauma. 2018 Jan 2. doi: 10.1089/neu.2017.5451. [Epub ahead of print].

"Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats"
Bezdudnaya T, Hormigo KM, Marchenko V, Lane MA.
Experimental Neurology V 305: 56-65, 2018.

"Dynamic changes in phrenic motor output following high cervical hemisection in the decerebrate rat"
Ghali MG, Marchenko V.
Exp Neurol 271: 379-389, 2015.

"Patterns of Phrenic Nerve Discharge after Complete High Cervical Spinal Cord Injury in the Decerebrate Rat"
Ghali MG, Marchenko V.
J Neurotrauma 32: 1-13, 2015.

Respiratory and Cardiovascular Control:

"Perturbations of Respiratory Rhythm and Pattern by Disrupting Synaptic Inhibition within Pre-Bötzinger and Bötzinger Complexes"
Marchenko V, Koizumi H, Mosher B, Koshiya N, Tariq MF, Bezdudnaya TG, Zhang R, Molkov Y, Rybak IA, Smith JC.
eNeuro May 13;3(2), 2016.

"Effects of vagotomy on hypoglossal and phrenic responses to hypercapnia in the decerebrate rat"
Ghali MG, Marchenko V.
Respir Physiol Neurobiol 232:13-21, 2016.

"The role of spinal GABAergic circuits in the control of phrenic nerve motor output"
Marchenko V, Ghali MGZ, Rogers RF.
Am J Physiol Regul Integr Comp Physiol 308(11): R916-R926, 2015.

"Cardiovascular responses to chemical stimulation of the lateral tegmental field and adjacent medullary reticular formation in the rat"
Marchenko V, Sapru HN.
Brain Research (977): 247-260, 2003.

"Different patterns of respiratory and cardiovascular responses elicited by chemical of dorsal medulla in the rat"
Marchenko V, Sapru HN.
Brain Research, 857(1-2): 99-109, 2000.

"Cardiovascular responses to chemical stimulation of the lateral tegmental field and adjacent medullary reticular formation in the rat"
Marchenko V, Sapru HN
Brain Research, 977: 247- 260, 2003.

"Different patterns of respiratory and cardiovascular responses elicited by chemical of dorsal medulla in the rat"
Marchenko V, Sapru HN
Brain Research, 857(1-2): 99-109, 2000.

"Pacemaker Properties of Respiratory Neurons of the Ventrolateral Medullary Regions in Early Postnatal Rats"
Marchenko VA, Voitenko LP, Volgin DV, Fenik VB, Vasilenko DA
Neirofiziologiya/Neurophysiology, Plenum Press, NY, USA, 28(6): 214-222, 1996.

Respiratory Control during Different Sleep Stages:

"Inhibition of A5 Neurons Facilitates the Occurrence of REM Sleep-Like Episodes in Urethane-Anesthetized Rats: A New Role for Noradrenergic A5 Neurons?"
Front. Fenik VB, Marchenko V, Davies RO, Kubin L.
Neurol 3(119): 1-12, 2012.

"A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol"
Fenik V, Marchenko V, Janssen P, Davies RO, Kubin L.
J. Appl. Physiol. (93): 1448-1456, 2002.

Functional Optical Imaging of Respiratory Activity:

"Spatiotemporal activity patterns during  respiratory rhythmogenesis in the rat ventrolateral medulla"
Fisher JAN, Marchenko VA, Yodh AG, Rogers RF
J. Neurophysiol. 95: 1982–1991, 2006.

Synchronous Oscillations among Respiratory Motor Neurons:

"Fast oscillations during gasping and other non-eupneic respiratory behaviors: Clues to central pattern generation (Review)"
Ghali MG, Marchenko V.
Respir Physiol Neurobiol. 187(2): 176-82, 2013.

"Motoneuron Firing Patterns Underlying Fast Oscillations in Phrenic Nerve Discharge in the Rat"
Marchenko V, Ghali MGZ, Rogers RF.
J. Neurophysiol J Neurophysiol (108): 2134-2143, 2012.

"GABAAergic and glycinergic inhibition in the phrenic nucleus organizes and couples fast oscillations in motor output"
Marchenko V, Rogers RF.
J. Neurophysiol. 101: 2134–2145, 2009.

"Temperature- and state-dependence of dynamic phrenic oscillations in the decerebrate juvenile rat"
Marchenko V, Rogers RF.
Am. J. Physiol. 293: R2323–R2335, 2007.

"Time-frequency coherence analysis of phrenic and hypoglossal activity in the decerebrate rat during eupnea, hyperpnea, and gasping"
Marchenko V, Rogers RF.
Am. J. Physiol. 291: R1430–R1442, 2006.

"Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping"
Marchenko V, Rogers RF.
Am. J. Physiol. 291: R1414–R1429, 2006.

"Respiratory cycle timing and fast inspiratory discharge rhythms in the adult decerebrated rat"
Marchenko V, Granata AR, Cohen MI.
Am J. Physiol. (283): R931-R940, 2002.

Information Transfer & Spike Train Encoding of Lung Stretch Receptors:

"Pulmonary stretch receptor spike time precision increases with lung inflation amplitude and airway smooth muscle tension"
Chen Y, Marchenko V, Rogers RF.
J. Neurophysiol (105): 2590-2600, 2011.

"Slowly adapting pulmonary stretch receptor spike patterns carry lung distension information"
Chen Y, Marchenko V, Rogers RF.
Neurosci Lett. 2010, 484: 86-91, 2010.

"Joint probability-based neuronal spike train classification"
Chen Y, Marchenko V, Rogers RF
Computational & Mathematical Methods in Medicine, 10:3, 229-239, 2009.

"Sparse firing frequency-based neuron spike train classification"
Chen Y, Marchenko V, Rogers RF.
Neurosci Lett. 2008, 439(1): 47-51, 2008.

"Classification performance of a sparse representation of instantaneous firing rate"
Chen Y, Marchenko V, Rogers RF
Neurosci Lett. 439: 47–51, 2008.

"Retention of lung distention information in pump cell spike trains"
Marchenko V, Rogers RF
Am. J. Physiol. 293: R343–R353, 2007.


Contact Information


Research Office

Department of Neurobiology & Anatomy
2900 W. Queen Lane
Philadelphia, PA 19129
Lab location: Queen Lane Room 174
Office Hours: 8 a.m. - 3 p.m. Monday - Friday
Phone: 215.991.8169
Fax: 215.843.9082