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Arundathi Jayatilleke

Arundathi Jayatilleke, MD

Associate Professor; Program Director, Rheumatology Fellowship

Department: Medicine: Division of Rheumatology

Practices: Drexel Rheumatology

Specialties: Rheumatology


  • MD - Duke University College of Medicine (2005)
  • MS with distinction - Yale University (2001)
  • BS with distinction, magna cum laude - Yale University (2001)

Awards & Honors

  • Clinician Scholar Educator Award, Rheumatology Research Foundation (2016)
  • Drexel University College of Medicine Professional Enrichment Grant (2015)
  • Outstanding Poster Presentation, Duke University School of Medicine Medical Student Research Day (2004)
  • Howard Hughes Medical Institute Research Training Fellowship for Medical Students, Duke University School of Medicine (2003)
  • Elected to Phi Beta Kappa (2001)

Memberships / Professional Affiliations

  • American College of Rheumatology
  • Association of Specialty Professors
  • Philadelphia Rheumatism Society
  • Association for Medical Education in Europe

Arundathi Jayatilleke, MD, is board certified in both internal medicine and rheumatology. She sees patients at Drexel Rheumatology, 219 N. Broad Street in Center City Philadelphia.

Clinical Services

Osteoarthritis, Osteoporosis, Rheumatoid arthritis, Systemic lupus erythematosus, Ankylosing spondylitis, Dermatomyositis, Gout, Polymyositis, Psoriatic arthritis


  • Rheumatology - Hospital for Special Surgery (2008-2011)


  • Internal Medicine - New York Presbyterian Hospital, Weill-Cornell Campus (2005-2008)


  • Internal Medicine - New York Presbyterian Hospital, Weill-Cornell Campus (2005-2008)

Arundathi Jayatilleke, MD, is an associate professor in the Department of Medicine, Division of Rheumatology at Drexel University College of Medicine. She is also director of the Rheumatology Fellowship program, course director for Year 2 PIL clinical skills and the rheumatology elective rotation, and associate pathways advisor for internal medicine.

Dr. Jayatilleke is developing an online game to teach medical students how to conduct exams for patients with rheumatoid arthritis, and intends to expand to other areas of rheumatology. The platform will teach the elements of muskuloskeletal exam using simulation. For this work she received the Clinician Scholar Educator Award from the Rheumatology Research Foundation in 2016.


Dr. Jayatilleke's research interests include ultrasound in the evaluation of osteoarthritis, ultrasound as a marker of disease activity in rheumatoid arthritis, and pregnancy and fertility counseling in autoimmune disease.


A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis.
Khan TA, Yin Luk FC, Uqdah HT, Arif A, Hussain H, Jayatilleke A, Aggarwal S.
Clin Nephrol.;83(5):309-14. doi: 10.5414/CN108322, May 2015

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.
Donlin LT, Jayatilleke A, Giannopoulou EG, Kalliolias GD, Ivashkiv LB.
J Immunol. 2014 Sep 1;193(5):2373-83. doi: 10.4049/jimmunol.1400486. Epub 2014 Jul 23, 2014

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Naga Prasad SV, Jayatilleke A, Madamanchi A, Rockman HA.
Nat Cell Biol.;7(8):785-96, August 2005

Contact Information

Practice Office

Drexel Rheumatology
219 N. Broad Street
The Arnold T. Berman, MD Building, 9th Floor
Philadelphia, PA 19107
Phone: 215.762.2688
Fax: 215.762.2689