The experience and expertise of the resource director and of the manager in the field of biomolecular interactions and interaction analysis is shown in the publications listed below. These include SPR kinetic interaction analysis, isolation of functional biomolecules and targets, and the investigation of structure-function relationships.

"Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein"
Nangarlia A, Hassen FF, Canziani G, Bandi P, Talukder C, Zhang F, et al.
ChemRxiv. Cambridge: Cambridge Open Engage; 2023

"Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge"
Gary EN, Tursi NJ, Warner BM, Cuismano G, Connors J, Parzych EM, Griffin BD, Bell MR, Ali AR, Frase D, Hojecki CE, Canziani G, Chaiken I, Kannan T, Moffat E, Embury-Hyatt C, Wooton SK, Kossenkov A, Patel A, Kobasa D, Kutzler MA, Haddad EK and Weiner DB
Front. Immunol., 14 March 2023. Sec. Vaccines and Molecular Therapeutics, Volume 14 - 2023

"Improved Durability to SARS-CoV-2 Vaccine Immunity Following Co-Immunization with Molecular Adjuvant Adenosine Deaminase-1"
Cusimano GM, Gary EN, Bell MR, Warner BM, Connors J, Tursi NJ, Ali AR, Zhang S, Canziani G, Taramangalam B, Gordon EA, Chaiken IM, Wootton SK, Smith T, Ramos S, Kobasa D, Weiner DB, Kutzler MA, Haddad EK
J Immunol. 2022 Jul 1;209(1):118-127. doi: 10.4049/jimmunol.2200056. Epub 2022 Jun 24. PMID: 35750334; PMCID: PMC9246991

"Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators"
Zhang, S., Holmes, A.P., Dick, A., Rashad, A.A., Enríquez Rodríguez, L., Canziani, G.A., Root, M.J., Chaiken, I.M.
Retrovirology, 2021

"Restricted HIV-1 Env glycan engagement by lectin-reengineered DAVEI protein chimera is sufficient for lytic inactivation of the virus"
Parajuli B, Acharya K, Bach HC, Parajuli B, Zhang S, Smith AB 3rd, Abrams CF, Chaiken I
Biochem J. 2018 Mar 9;475(5):931-957. doi: 10.1042/BCJ20170662. PMCID: PMC5944358

"Peptide triazole inactivators of HIV-1 utilize a conserved two-cavity binding site at the junction of the inner and outer domains of Env gp120"
Aneja R, Rashad AA, Li H, Kalyana Sundaram RV, Duffy C, Bailey LD, Chaiken I
J Med Chem. 58(9): 3843-58, 2015. PMCID: PMC4497506

"Llama nanoantibodies with therapeutic potential against human norovirus diarrhea"
Garaicoechea L, Aguilar A, Parra GI, Bok M, Sosnovtsev SV, Canziani G, Green KY, Bok K, Parreño V
PLoS One. 2015 Aug 12;10(8):e0133665. doi: 10.1371/journal.pone.0133665. PMCID: PMC4534396

"HIV-1 Env gp120 Structural Determinants for Peptide Triazole Dual Receptor Site Antagonism"
Tuzer F, Madani M, Kantharaju Zentner I, LaLonde J, Holmes A, Upton E, Rajagopal S, McFadden K, Contarino M, Sodroski, Chaiken I
Proteins: Structure, Function, and Bioinformatics 81(2): 271-290, 2013. PMCID: PMC3731144

"Characterization of neutralizing affinity-matured human respiratory syncytial virus F binding antibodies in the sub-picomolar affinity range"
Canziani GA, Melero JA, Lacy ER
J Mol Recognit. 2012 Mar;25(3):136-46. doi: 10.1002/jmr.2149

"A Protein Engineering Approach Differentiates the Functional Importance of Carbohydrate Moieties of Interleukin-5 Receptor α."
Ishino T, Economou NJ, McFadden K, Zaks-Zilberman M, Jost M, Baxter S, Contarino MR, Harrington AE, Loll PJ, Pasut G, Lievens S, Tavernier J, Chaiken I
Biochemistry. 50(35): 7546-56, 2011. PMCID: PMC21770429

"Slow-dissociation effect of common signaling subunit beta on IL5 and GM-CSF receptor assembly"
Ishino T, Harrington A, Zaks-Zilberman M, Scibek J, Chaiken I
Cytokine 42: 179-90, 2008. PMCID: PMC2587307

"Kinetic screening of antibodies from crude hybridoma samples using Biacore"
Canziani GA, Klakamp S, Myszka DG
Anal Biochem. 2004 Feb 15;325(2):301-7

"Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220"
Sarrias MR, Franchini S, Canziani GA, Argyropoulos E, Moore WT, Sahu A, Lambris JD
J. Immunol. 167, 1490-1499, 2001

"A novel biosensor assay for studying ligand-membrane receptor interactions"
Hoffman TL, Canziani GA, Jia L, Rucker J, Doms RW
Proc. Natl. Acad. Sci. USA 97, 11215-11220, 2000

"A molecular basis for functional peptide mimicry of a carbohydrate antigen"
Luo P, Canziani GA, Chang TY, Counto-Amesty G, Kieber-Emmons T
J. Biol. Chem. 275, 16146-16154, 2000

"Stable exposure of the coreceptor-binding site in a CD4-independent HIV- 1 envelope protein"
Hoffman T, LaBranche CC, Zhang W, Canziani G, Robinson J, Chaiken IM, Hoxie JA, Doms RW
T. L. Proc. Natl. Acad. Sci. USA 1999, 96, 6359-6364

"Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic"
Zhang W, Canziani G, Plugariu C, Wyatt R, Sodroski J, Sweet R, Kwong P, Hendrickson W, Chaiken I
Biochemistry 1999, 38, 9405-9416

"Exploring biomolecular recognition using optical biosensors"
Canziani G, Zhang W, Cines D, Rux A, Willis S, Cohen G, Eisenberg R, Chaiken, I
Methods 19: 253-269, 1999

"New opportunities for using immobilized ligands to characterize macromolecular recognition and design recognition molecules"
Chaiken I, Myszka D, Morton T
Advances in Molecular and Cellular Biology 15B: 553-568, 1996

 
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