Microbes & Alzheimer’s: Bridging Silos to Accelerate Innovation

Saturday, July 27, 2024

8:00 AM-7:00 PM

Topic
Microbes & Alzheimer’s: Bridging Silos to Accelerate Innovation

Agenda:
8:00 – 9:00am Breakfast
9:00 – 10:45am Presentations

• Dr. Brian Balin, Nikki Schultek, IDSA Opening remarks
• Nikki Schultek, AlzPI “Unraveling the role of infections in Alzheimer’s through patient-led, global interdisciplinary collaboration”
• Dr. Brian Balin, PCOM & AlzPI "Evaluating infection in Alzheimer disease pathogenesis”
• Dr. Garth Ehrlich and Dr. Michiko Thwe, Drexel “Application of a species-specific, trans-pan-domain molecular diagnostic to Alzheimer disease (AD) brains reveals AD pathobiomes that are distinct from agematched controls.”
• Dr. David Corry and Lynn Bimler, Baylor “A ubiquitous Candida albicans-based polymicrobial human brain infection causes Alzheimer’s Disease-like changes in mice”

10:45 – 11am Questions & Break
11am – 12:20pm Presentations

• Dr. Kevin Zwezdaryk and Sara Morris, Tulane “Intermittent CMV infection promotes mitochondrial dysfunction contributing to Alzheimer’s Disease progression”
• Nikki Schultek, AlzPI “Unraveling the role of infections in Alzheimer’s through patient-led, global interdisciplinary collaboration”
• Dr. Elizabeth Bradshaw and Dr. Zena Chatila, Columbia “Pathogens, Microglia and Alzheimer’s Disease”
• Dr. Edward Breitschwerdt and Dr. Janice Bush, NC State “Bartonella henselae, Neurobartonellosis and Alzheimer’ Disease: Is there a link?”
• Dr. Or Shemesh and Vanesa Hyde, B.A., Univ. of Pittsburgh “Alzheimer’s Disease pathologies are pathogen-driven and cell protective”

12:20 – 1:15pm Lunch
1:15 – 3:05pm Presentations

• *Keynote* Dr. Wenyuan Shi, Forsyth Institute “Exploring the connection between oral microbiome and Alzheimer’s disease ”
• Dr. Ruth Itzhaki, Oxford “Repetitive concussive injury, like cumulative infections, causes Alzheimer’s disease-like phenotypes via reactivation of HSV-1 in a 3D human brain tissue model”
• Dr. William Eimer, MGH and Harvard “Amyloid Beta and Tau: Exploring the antimicrobial connection between pathogens and Alzheimer’s disease”
• Dr. Laura Cox, Harvard “The role of Bacteroides in Alzheimer’s disease. ”
• Dr. Monica Embers, Tulane “Borrelia Infection in the Genesis of Dementia”

3:05 – 3:20pm Questions & Break
3:20 – 3:40pm Presentations

• Dr. Lavinia Alberi, VitalizeDx and AlzPI “Oral-host pathogen interactions, from early noninvasive diagnostics to timely therapeutics for Alzheimer’s Disease”
• Dr. Michael Detke, Lighthouse Therapeutics “Phase 1 SAD/MAD data and Phase 2 study design for LHP588, a second-generation gingipain inhibitor for the treatment of P. gingivalis-positive Alzheimer’s dementia”
• *Keynote* Col. Nicole Malachowski (ret.), USAF “Breaking Barriers”
• Dr. Laura Cox, Harvard “The role of Bacteroides in Alzheimer’s disease. ”
• Dr. Brian Balin, Dr. Ruth Itzhaki, & Dr. George Perry Pioneer’s Panel Discussion

5 – 7pm Cocktail Hour & Networking in the Lobby

Register Here