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Department of Pathology & Laboratory Medicine Molecular Diagnostics Laboratory

The Molecular Diagnostic Laboratory (MDL) at Drexel University College of Medicine is housed in the Department of Pathology and Laboratory Medicine and is focused on diagnosis, education and clinical research.

MDL is accredited by the Clinical Laboratory Improvement Amendments (CLIA) and the College of American Pathologists (CAP).

Clinical Services

The MDL offers a variety of clinical molecular tests that can help diagnosis and inform treatment options for patients with neoplastic disorders, especially lung and colon adenocarcinomas. The MDL uses next-generation sequencing (NGS) to provide highly sensitive, comprehensive and accurate analysis of somatic mutations in several genes using an amplicon hotspot library. Fluorescent in situ hybridization (FISH) analysis is also performed to identify lung adenocarcinomas with ALK or ROS1 rearrangements. In addition, the MDL performs IGH clonality and TCR gamma (TCRγ) gene rearrangement assays to aid in the diagnosis of B- and T-cell lymphomas.

The MDL specializes in small samples, i.e., biopsies, and will work with requesting physicians to obtain the optimal results from difficult specimens. The MDL also performs Factor V Leiden (G1691A) and Prothrombin (G20210A) gene mutation assays to identify patients with a higher risk of thrombosis.

All DNA mutation tests have a sensitivity of 5% mutant DNA in a wild-type background. 

Learn more about our services

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