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Issa Zakeri, PhD

Issa Zakeri

Professor of Biostatistics
Epidemiology and Biostatistics
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PhD, Statistics, University of Illinois at Urbana-Champaign
MS, Mathematics, University of Illinois at Urbana-Champaign
BS, Mathematics, University of Tehran


Issa Zakeri's research interests include biostatistics, functional data analysis, multivariate analysis and statistical learning. His methodological research has been motivated by and closely related to his applied interests in behavioral, biological and medical sciences. In particular, he has methodological and applied research interests related to obesity prevention and energy expenditure, and have engaged in obesity prevention research at the biologic, clinical and community levels.

Research Interests

  • Data Analysis Methods
  • Statistical Modeling


Mastrianni A, Sarcevic A, Chung LS, Zakeri I, Alberto EC, Milestone ZP, Burd RS, Marsic I. Designing Interactive Alerts to Improve Recognition of Critical Events in Medical Emergencies. DIS (Des Interact Syst Conf). 2021 Jun;2021:864-878. doi: 10.1145/3461778.3462051. Epub 2021 Jun 28. PMID: 35330919; PMCID: PMC8941664.

Butte NF, Puyau MR, Wilson TA, Liu Y, Wong WW, Adolph AL, Zakeri IF. Role of physical activity and sleep duration in growth and body composition of preschool-aged children. Obesity (Silver Spring). 2016 Jun;24(6):1328-35. doi: 10.1002/oby.21489. Epub 2016 Apr 18. PMID: 27087679; PMCID: PMC4882246.

Lee JS, Zakeri IF, Butte NF. Functional data analysis of sleeping energy expenditure. PLoS One. 2017 May 10;12(5):e0177286. doi: 10.1371/journal.pone.0177286. PMID: 28489875; PMCID: PMC5425044.

De Roos AJ, Gurian PL, Robinson LF, Rai A, Zakeri I, Kondo MC. Review of Epidemiological Studies of Drinking-Water Turbidity in Relation to Acute Gastrointestinal Illness. Environ Health Perspect. 2017 Aug 17;125(8):086003. doi: 10.1289/EHP1090. PMID: 28886603; PMCID: PMC5882241.

Butte NF, Liu Y, Zakeri IF, Mohney PR, Mehta N, Vourganti VS, Goring H,  and Comuzzie AG. Global metabolomic profiling targeting childhood obesity in the Hispanic population. (2015) American Journal of Clinical Nutrition 102(2):256-67.

Butte NF, Wong WW, Lee JS, Adolph AL, Puyau MR, and Zakeri IF. (2014) Prediction of Energy Expenditure and Physical Activity in Preschoolers. Medicine and Science in Sports and Exercise 46(6):1216-26.

Yang Y, Adolph A, Puyau M, Vohra F, Butte N, and Zakeri I. (2013). Modeling Energy Expenditure in Children and Adolescents using Quantile Regression. Journal of Applied Physiology 115(2):251-9.

Zakeri I, Adolph A, Puyau MR, Vohra FA, Butte N. (2013) Cross-sectional Time Series and Multivariate Adaptive Regression Splines Models Using Accelerometers and Heart Rate Predict Energy Expenditure of Preschoolers. The Journal of Nutrition 143(1): 114-122

Barati Z, Zakeri I, Pourrezaei K.  (2013) Functional Data Analysis View of Functional Near Infrared Spectroscopy Data. Journal of Biomedical Optics 18(11): 117007-1-13

Zakeri I, Adolph A, Puyau MR, Vohra FA, Butte N. Multivariate Adaptive Regression Splines (MARS) Models for the Prediction of Energy Expenditure in Children and Adolescents. (2010). Journal of Applied Physiology 108(1): 128-136.

View Dr. Zakeri's complete list of publications on PubMed


PBHL 622 Statistical Inference I

PBHL 684 Statistical Inference II

PBHL 696 Nonparametric and Semiparametric Models