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Disease Biology

Department of Biology

C. elegans model of aggregation-prone SOD1 mutant protein. Green - SOD1-YFG fusion protein, 127x mutant; red - muscle actin. Photography by Tali Gidalevitz

The Disease Biology research group aims to understand and treat a variety of human diseases. Our faculty use a range of model systems and experimental approaches to discover the underlying causes of human disease and devise new therapeutic strategies. Faculty work on neurodegenerative and protein aggregation diseases such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis (ALS); developmental disorders such as Fragile X syndrome, autism, CHARGE syndrome and Pitt-Hopkins; multiple forms of cancer; spinal cord injury; and autoimmune disorders such as multiple sclerosis. Biology faculty collaborate with clinical and basic scientists from the Drexel College of Medicine, which focuses on translational, bench-to-bedside research.

Faculty Members

  Faculty Member Expertise
Aly Afify
Assistant Professor
PISB 421
aa4686@drexel.edu
  • Insect olfaction
  • Sensory Neurobiology
  • Mosquito oviposition
  • Malaria
Felice Elefant , Ph.D.
Professor
PISB 317
fe22@drexel.edu
  • The Elefant Lab
  • Understanding epigenetic mechanisms that govern higher order brain function via chromatin packaging in neurons
  • Understanding the role(s) of specific HATs in higher order brain function and neurodegenerative disorders such as Alzheimer’s disease
Tali Gidalevitz
Associate Professor; Co-Director, Graduate Biology Program
PISB 418
Tali.gidalevitz@drexel.edu
  • Protein misfolding diseases, such as Alzheimer's or Parkinson's diseases
  • The mechanism of differential neuronal susceptibility to protein misfolding
  • The role of natural genetic variation and physiological stress in proteostasis
  • Maintaining the ER proteostasis under physiological stress
Ryan Petrie, PhD
Associate Professor
PISB 419
3245 Chestnut Street,
Philadelphia, PA 19104

rjp336@drexel.edu
  • The Petrie Dish: Research Lab
  • Extracellular matrix
  • Cell motility
  • Cytoskeleton
  • Mechanotransduction
  • Cell-matrix interactions
  • Cell biology
  • Intracellular signaling
Nianli Sang, M.B., Ph.D.
Associate Professor
PISB 417
nianli.sang@drexel.edu
  • Understanding of cells’ response to insufficiency of oxygen, glucose and glutamine supplies, a condition commonly occurring in solid tumors and ischemic lesions
  • Cellular level sensing systems for glucose and glutamine
  • How oncogenic signaling pathways stimulate and coordinate the utilization of glucose and glutamine
  • How lack of glucose and glutamine together with hypoxia contributes to tumor migration and metastasis
  • How does the ER stress responsive pathway play critical roles in tumor resistance to chemo-radiotherapy