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Biochemistry Research

DNA molecules. Photograph by Charles Clegg.

Researchers in biochemistry investigate the metabolic processes affecting nutrients and cellular components. This includes the biosynthesis, processing, intracellular trafficking and disposal of biomolecules such as proteins and lipids. It also includes studies on the maintenance of intracellular homeostasis involving bioenergetics and redox status. Major foci are the regulatory mechanisms of homeostasis and adaptation to changes of the microenvironment such as nutrient depletion or disease conditions; signaling pathways in physiological and pathological conditions; and pathological accumulation of macromolecules or metabolites from enzyme defects. The long-term goal of much of this work in our department is to identify molecular targets for the prevention and treatment of human disease. Additional research interests include studies of drug disposal, pharmacokinetics, and mechanisms of drug resistance. Biology faculty in this research area collaborate with investigators in the Sydney Kimmel Cancer Center, pharmaceutical industries such as GlaxoSmithKline, and other institutes worldwide.

Faculty conducting research in Biochemistry

Contact Specialization
Dr. Joseph Bentz
Professor Emeritus
PISB 416
Biophysics of Cell Membrane Function - Membrane Transport by Multidrug Resistance Proteins, chanisms of Membrane Fusion, Peptide/Protein-Membrane Interactions
Tali Gidalevitz
Associate Professor
PISB 418

My lab aims to understand the mechanisms that maintain healthy protein folding environment in the cell, and how they fail in neurodegenerative diseases and aging. We use genetic and live imaging approaches in a genetically tractable organism, C. elegans, as discovery tools, and apply the findings to mammalian systems.

Nianli Sang, M.B., Ph.D.
Associate Professor
PISB 417
Molecular, Cellular and Biochemical Bases of Major Human Diseases
Aleister Saunders, PhD
Executive Vice Provost for Research & Innovation; Professor
104 Left Bank
Biochemistry, Genetics, Molecular/Cellular Biology