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Lin Han

Lin Han, PhD

School of Biomedical Engineering, Science and Health Systems

Office: Bossone 711
Phone: 215.895.3821
Website: Nanobiomechanics Laboratory


Lin Han obtained his BE degree from Tsinghua University in Beijing, P. R. China, and his PhD degree from the Massachusetts Institute of Technology in the area of Bio- and Polymeric Materials. After graduation, he worked as a quantitative analyst in Aristeia Capital, LLC from Sept. 2007 to June 2009, responsible for developing and testing statistical models. He then worked as a post-doctoral associate in the Department of Materials Science and Engineering and the Center for Biomedical Engineering at MIT from July 2009 to Sept. 2012. He will start his assistant professor position in the School of Biomedical Engineering, Science and Health Systems at Drexel University in November 2012. His research interests focus on exploring the nanoscale structure-property relationships of biomaterials, which aim to provide important insights into the application of disease diagnostics, tissue regeneration and bio-inspired material design. Dr. Han joined the faculty of Drexel's School of Biomedical Engineering, Science and Health Systems in November 2012.


  • PhD, Massachusetts Institute of Technology, Bio- and Polymeric Materials, 2007
  • BE, Tsinghua University, Materials Engineering, 2002

Research Interests

Nanoscale structure-property relationships of biological materials, genetic and molecular origins of soft joint tissue diseases, biomaterials under extreme conditions, coupling between stimulus-responsiveness and geometry


A. R. Altman-Singles, Y. Jeong, W.-J. Tseng, C. M. J. de Bakker, H. Zhao, C. Lott, J. Robberts, L. Qin, L. Han, D.-G. Kim, and X. S. Liu. Intermittent parathyroid hormone after prolonged alendronate treatment induces substantial new bone formation and increases bone tissue heterogeneity in ovariectomized rats. J. Bone Miner. Res. In press, doi: 10.1002/jbmr.3165.
K. Prudnikova, R. Yucha, P. Patel, A. Kriete, L. Han, L. Penn, and M. S. Marcolongo. Biomimetic proteoglycans mimic macromolecular architecture and water uptake of natural proteoglycans. Biomacromolecules 2017. In press, doi: 10.1021/acs.biomac.7b00032.

Q. Li, F. Qu, B. Han, C. Wang, H. Li, R. L. Mauck, and L. Han. Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix. Acta Biomater. 2017. 54: 356-366.

D. Chen, J. Shen, W. Zhao, T. Wang, L. Han, J. J. Hamilton, and H.-J. Im. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017. 5: 16044.

B. DoyranΔ, W. TongΔ, Q. Li, H. Jia, X. Zhang, C. Chen, M. Enomoto-Iwamoto, X. L. Lu, L. Qin, and L. Han. Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis. Osteoarthr. Cartil. 2017. 25: 108-117. (Δ: equal contribution)

H. Jia, X. Ma, W. Tong, B. Doyran, Z. Sun, Z. Yang, X. Zhang, J. Wang, L. Han, M. Enomoto-Iwamoto, and L. Qin. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis progression. Proc. Natl. Acad. Sci. USA 2016. 113: 14360-14365.
C. B. Rodell, C. B. Highley, M. H. Chen, N. N. Dusaj, C. Wang, L. Han, and J. A. Burdick. Evolution of hierarchical porous structures in supramolecular guest-host hydrogels. Soft Matter. 2016. 12: 7839-7847.
A. Goyal, M. A. Gubbiotti, D. R. Chery, L. Han, and R. V. Iozzo. Endorepellin-evoked autophagy contributes to angiostasis. J. Biol. Chem. 2016. 37: 19245-19256.
M. E. Candela, C. Wang, A. T. Gunawardna, K. Zhang, L. Cantley, Y. Usami, N. Francois, A. van der Flier, R. O. Hynes, Y. Zhang, L. Qin, L. Han, and M. Enomoto-Iwamoto. Alpha 5 integrin mediates osteoarthritic changes in mouse knee joints. PLoS One. 2016. 11: e0156783.
T. Zhou, H. Qi, L. Han, D. Barbash, and C. Y. Li. Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach. Nat. Comm. 2016. 7: 11119.
W. Wang, H. Qi, T. Zhou, S. Mei, L. Han, T. Higuchi, H. Jinnai, and C. Y. Li. Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface. Nat. Comm. 2016. 7: 10599.
P. Shi, E.-Y. Chen, G. Cs-Szabo, A. Chee, C. Tanoury, L. Qin, L. Han, S. An, H. An, and Y. Zhang. Biglycan inhibits capsaicin-induced substance P release by cultured dorsal root ganglion neurons. Am. J. Phys. Med. Rehabil. 2016. 95: 656-662.
B. K. Connizzo, L. Han, D. E. Birk, and L. J. Soslowsky. Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales. Interface Focus 2016. 6: 20150043.
B. Han, D. R. Chery, J. Yin, X. L. Lu, D. Lee, and L. Han*. Nanomechanics of layer-by-layer polyelectrolyte complexes: a manifestation of ionic cross-links and fixed charges. Soft Matter 2016. 12: 1158-1169.

Y. Tang, G. Lin, L. Han, S. Qiu, S. Yang, and J. Yin. Engineering hierarchical cuts for extremely soft, high strength, and reconfigurable auxetic metamaterials. Adv. Mater. 2015. 27: 7181-7190.
Z. Zhang, Q. Li, L. Han, and Y. Zhong. Layer-by-layer films assembled from natural polymers for sustained release of neurotrophin. Biomed. Mater. 2015. 10: 055006.
L. Ruggiero, B. K. Zimmerman, M. Park, L. Han, L. Wang, D. L. Burris, and X. L. Lu. Roles of fibrous superficial zone in the mechanical behavior of TMJ condyle cartilage. Ann. Biomed. Eng. 2015. 11: 2652-2662.
Q. Li, B. Doyran, L. W. Gamer, X. L. Lu, L. Qin, C. Ortiz, A. J. Grodzinsky, V. Rosen, and L. Han. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. J. Biomech. 2015. 48: 1364-1370.

H. T. Nia, L. Han, I. S. Bozchalooi, P. Roughley, K. Youcef-Toumi, A. J. Grodzinsky, and C. Ortiz. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano 2015. 9: 2614-2625.
B. Lee Δ, L. Han,Δ E. H. Frank, A. J. Grodzinsky, and C. Ortiz. Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation. J. Biomech. 2015. 48: 171-175. (Δ: equal contribution)
B. K. Connizzo, J. J. Sarver, L. Han, and L. J. Soslowsky. In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons. J. Biomech. 2014. 47: 3794-3798.
M. A. Batista, H. T. Nia, P. Önnerfjord, K. A. Cox, C. Ortiz, A. J. Grodzinsky, D. Heinegård, and L. Han. Nanomechanical phenotype of chondroadherin-null articular cartilage. Matrix Biol. 2014. 38: 84-90.
M. K. Saums, W. Wang, B. Han, L. Madhavan, L. Han, D. Lee, and R. G. Wells. Mechanically- and chemically-tunable cell culture system to study myofibroblast phenotype. Langmuir 2014. 30: 5481-5487.
F. P. Rojas, M. A. Batista, C. A. Lindburg, D. Dean, A. J. Grodzinsky, C. Ortiz, and L. Han. Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules 2014. 15: 772-780.

C. A. Rock, L. Han, and T. C. Doehring. Complex fiber and membrane morphologies of the whole porcine aortic valve. PLoS One 2014. 9: e86087.
H. T. Nia, I. S. Bozchalooi, Y. Li, L. Han, H.-H. Hung, E. H. Frank, K. Youcef-Toumi, C. Ortiz, and A. J. Grodzinsky. High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys. J. 2013. 104: 1529-1537.
H.-Y. Lee,Δ L. Han,Δ P. J. Roughley, A. J. Grodzinsky, and C. Ortiz. Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. J. Struct. Biol. 2013. 181: 264-273. (Δ: equal contribution)
2012 and Earlier
L. Han, J. Yin, L. Wang, K.-K. Chia, R. E. Cohen, M. F. Rubner, C. Ortiz, and M. C. Boyce. Tunable stimulus-responsive friction mechanisms of polyelectrolyte films and tube forests. Soft Matter 2012. 8: 8642-8650.
S. Y. Wong, L. Han, K. Timachova, J. Veselinovic, M. H. Hyder, C. Ortiz, A. M. Klibanov, and P. T. Hammond. Drastically lowered protein adsorption on microbicidal hydrophilic/hydrophobic polyelectrolyte multilayers. Biomacromolecules 2012. 13: 719-726.
L. Han, L. Wang, K.-K. Chia, R. E. Cohen, M. F. Rubner, M. C. Boyce, and C. Ortiz. Geometrically controlled mechanically responsive polyelectrolyte tube arrays. Adv. Mater. 2011. 23:  4667-4673.
H. T. Nia, L. Han, Y. Li, C. Ortiz, and A. J. Grodzinsky. Poroelasticity of cartilage at the nanoscale. Biophys. J. 2011. 101: 2304-2313.
L. Han, L. Wang, J. Song, M. C. Boyce, and C. Ortiz. Direct quantification of the mechanical anisotropy and fracture of an individual exoskeleton layer via uniaxial compression of micropillars. Nano Lett. 2011. 11: 3868-3874.
L. Han, A. J. Grodzinsky, and C. Ortiz. Nanomechanics of the cartilage extracellular matrix. Annu. Rev. Mater. Res. 2011. 41: 133-168.
L. Han, E. H. Frank, J. J. Greene, H.-Y. Lee, H. K. Hung, A. J. Grodzinsky, and C. Ortiz. Time-dependent nanomechanics of cartilage. Biophys. J. 2011. 100: 1846-1854.
B. Lee, L. Han, E. H. Frank, S. Chubinskaya, C. Ortiz, and A. J. Grodzinsky. Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes. J. Biomech. 2010. 43: 469-476.
K. Tai, G. Pelled, D. Sheyn, A. Bershteyn, L. Han, I. Kallai, Y. Zilberman, C. Ortiz, and D. Gazit. Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells. Tissue Eng. A 2008. 14: 1709-1720.
L. Han, D. Dean, L. A. Daher, A. J. Grodzinsky, and C. Ortiz. Cartilage aggrecan can undergo self-adhesion. Biophys. J. 2008. 95: 4862-4870.
L. Han, D. Dean, P. Mao, C. Ortiz, and A. J. Grodzinsky. Nanoscale shear deformation mechanisms of opposing aggrecan macromolecules. Biophys. J. 2007. 93: L23-L25.
L. Han, D. Dean, C. Ortiz, and A. J. Grodzinsky. Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys. J. 2007. 92: 1384-1398.
M. Ye, D. Zhang, L. Han, J. Tejeda, and C. Ortiz. Synthesis, preparation and conformation of stimulus-responsive end-grafted poly(methacrylic acid-g-ethylene glycol) layers. Soft Matter 2006. 2: 243-256.
D. Dean, L. Han, A. J. Grodzinsky, and C. Ortiz. Compressive nanomechanics of opposing aggrecan macromolecules. J. Biomech. 2006. 39: 2555-2565.
D. Dean, L. Han, C. Ortiz, and A. J. Grodzinsky. Nanoscale conformation and compressibility of cartilage aggrecan using microcontact printing and atomic force microscopy. Macromolecules 2005. 38: 4047-4049.
S. M. Zhang, F. Z. Cui, S. S. Liao, Y. Zhu, and L. Han. Synthesis and biocompatibility of porous nanohydroxyapatite/collagen/alginate composite. J. Mater. Sci. Mater. Med. 2003. 14: 641-645.